Modern approaches to neuroprotective treatment of ischemic stroke
Abstract
The authors present the results of domestic clinical trials on the efficacy and safety of mexidol in patients with cerebrovascular disorders including ischemic stroke (IS). The use of mexidol is associated with complete and rapid regression of the focal neurological deficit. Mexidol is well tolerated with no significant side-effects. The drug is recommended for enteral and parenteral administration in patients with IS.
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In clinical and experimental stroke, Mexidol treatment was associated with a decrease in brain damage and the efficient recovery of cognitive and sensorimotor functions.
“In a clinical and experimental stroke, the Mexidol treatment was associated with a decrease in brain damage and the efficient recovery of cognitive and sensorimotor functions [55,56,57,58].”
From Protective Effects of PGC-1α Activators on Ischemic Stroke in a Rat Model of Photochemically Induced Thrombosis (2021) · cites this paper as [56]
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References 7 · Cited by 11
- Authors
- Stakhovskaya, L. V., Tyutyumova, E. A., & Fedin, A. I.
- Affiliations
- Pirogov Russian National Research Medical University (RU)
- ORCID
- Stakhovskaya, L. V.
- Venue
- Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova
- Publisher
- Media Sphere Publishing House
- Published
- 2017
- Volume
- 117
- Issue
- 8
- Pages
- 75
- ISSN
- 1997-7298 (ISSN-L)
- OpenAlex
- W2761391481
- Cited by
- 11
- References
- 7
- Citations by year
- 2023: 3 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 1
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- S S Korsakov Journal of Neurology and Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Medical and Pharmaceutic Studies
- Keywords
- Mexidol, ischemic stroke, neuroprotection, cerebrovascular disease, focal neurological deficits, drug safety and efficacy
- MeSH terms
- Brain Ischemia, Cerebrovascular Disorders, Humans, Neuroprotective Agents, Stroke
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