Resveratrol and Spirulina: Nutraceuticals that potentially improving cardiovascular disease
Open accessAbstract
Resveratrol (3,5,4’-trihydroxy-trans-stilbene) is an extensively studied nutraceutical with several proposed health benefits, including cardio protection, antimetabolic syndrome, and antiatherogenic effects. It was brought to popularity through the proposed “French Paradox” and the consumption of red wine. It has been shown to down regulate the activation of numerous inflammatory and oxidative stress markers with therapeutic potentials. Spirulina (Arthrospira platensis), on the other hand, is a highly nutritional nutraceutical that has not been sufficiently studied. However, several in vitro and animal studies point to its hypolipidemic and antihypertensive properties, which are similar to resveratrol. Although resveratrol and Spirulina both constitutes functional foods with potential therapeutic effects on several cardiovascular diseases, there are few compelling clinical evidence to support their applications in human patients. This warrant further evaluation in clinical trials. This article reviews and evaluates the beneficial effects of the two different nutraceuticals in order to demonstrate their potential in clinical application in patients with cardiovascular diseases.
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Spirulina algae, when consumed as a functional food, aids in the treatment of cardiovascular disorders such as high cholesterol and atherosclerosis.
“Spirulina algae, when consumed as a functional food, has been shown to aid in the treatment of cardiovascular disorders such as high cholesterol and atherosclerosis, as validated by Wang et al. [162].”
From Trends and Technological Advancements in the Possible Food Applications of Spirulina and Their Health Benefits: A Review. (2022) · cites this paper as [162]
The clinical-evidence section reports improved lipid measures in a preliminary human study and reduced atherosclerotic lesions in rabbits. But it says the cholesterol result lacked established clinical significance, while the atherosclerosis finding was in animals and concerned protection against progression. The citing sentence presents these as established treatment benefits without those qualifications. (LLM, conf=0.87)
Experimental — accuracy not yet measuredThe pigment phycocyanin in spirulina is thought to be responsible for the preventive effect that spirulina has against cardiovascular diseases.
“The pigment phycocyanin in spirulina, which has properties comparable to those of the pigment bilirubin in terms of its structure, is thought to be responsible for the preventive effect that spirulina has against CVDs.”
From Trends and Technological Advancements in the Possible Food Applications of Spirulina and Their Health Benefits: A Review. (2022) · cites this paper as [162]
The Introduction says spirulina may help prevent CVD, and the “-Spirulina” discussion says some reports suggest C-phycocyanin contributes to its cholesterol effects. The paper also describes phycocyanin’s anti-inflammatory activity, but does not attribute spirulina’s overall proposed preventive effect against CVD to that pigment specifically. (LLM, conf=0.82)
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References 60 · Cited by 8
Research works printed but not linked: 3
- Resveratrol Dose By The Annals of the New York Academy of Sciences. Rev Genetics. Link: https://bit.ly/2yoP762 Citation:
- Wang Y, Ocampo MF, Rodriguez B, Chen J (2020) Resveratrol and Spirulina: Nutraceuticals that Potentially Improve Cardiovascular Disease. J Cardiovasc Med Cardiol 7(2): 138-145. DOI: https://dx.doi.org/10.17352/2455-2976.000129
- Stervbo U, Vang O, Bonnesen C (2007) A review of the content of the putative chemopreventive phytoalexin resveratrol in red wine. Food Chem 101: 449- 457. Link: https://bit.ly/3eeHy0W
- Authors
- Wang, Y., Ocampo, M. F., Rodriguez, B., & Chen, J.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Chen, Jiwang
- Venue
- Journal of Cardiovascular Medicine and Cardiology
- Published
- 2020-05-25
- Volume
- 7
- Issue
- 2
- Pages
- 138-145
- ISSN
- 2455-2976 (ISSN-L)
- OpenAlex
- W3036117644
- Cited by
- 8
- References
- 60
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Update notices
- new_edition (2020-05-25)
- Open access
- diamond
- doi.org
- Licence
- Locations
- Journal of Cardiovascular Medicine and Cardiology (publishedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Keywords
- resveratrol, Spirulina, Spirulina platensis, nutraceuticals, cardiovascular disease, cardioprotection, metabolic syndrome, atherosclerosis, oxidative stress, inflammation, hypolipidemic effect, antihypertensive effect, functional foods, red wine, French paradox
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