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Infliximab relieves blood retinal barrier breakdown through the p38 MAPK pathway in a diabetic rat model
Open accessAbstract
Aim To clarify the mechanism of infliximab treatment in diabetic macular edema (DME) and to provide a new alternative therapy for DME. Methods Rats were randomly divided into the control group, the model group and the infliximab treatment group. A diabetic rat model was created. The concentration of TNF-α in the vitreous body was detected by ELISA. The expressions of B-Raf, p38, claudin-1 and occludin in the retina were detected by Western blot. The integrity of the blood retinal barrier (BRB) was measured using Evan's blue as a tracer. Results After three months and six months of the diabetes model, the vitreous TNF-α level in the model group was higher than that of the control group. It was also higher in treated group than that of the control group but was lower than that of the model group. The differences among the three groups were statistically significant (at 3mo, F =857.098, P F =1261.897, P F =106.596, P F =200.681, P F =41.662, P F =67.979, P F =139.088, P F =128.415, P F =92.733, P F =104.478, P F =447.946, P F =1610.732, P Conclusion In a diabetic rat model, infliximab may relieve TNF-α induced BRB breakdown via the B-Raf and p38 signaling pathway.
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“and for the prevention of macular edema [ 88 , 89 , 90 , 91 ]”
From MAPK Pathways in Ocular Pathophysiology: Potential Therapeutic Drugs and Challenges (2023) · cites this paper as [90]
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References 36 · Cited by 10
Metadata
- Authors
- Xie, M., Zheng, Y., Huang, L., & Xu, G.
- Affiliations
- First Affiliated Hospital of Fujian Medical University (CN)
- Fujian University of Traditional Chinese Medicine (CN)
- Venue
- International Journal of Ophthalmology
- Published
- 2017-12-18
- Volume
- 10
- Issue
- 12
- Pages
- 1824-1829
- ISSN
- 2222-3959 (ISSN-L)
- 2227-4898
- PMC
- PMC5733508
- OpenAlex
- W2795227276
- Cited by
- 10
- References
- 36
- Citations by year
- 2024: 2 · 2023: 4 · 2021: 1 · 2020: 2 · 2019: 1
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- International Journal of Ophthalmology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- infliximab, diabetic macular edema, blood-retinal barrier, p38 MAPK pathway, TNF-α, BRAF, claudin-1, occludin, tight junction proteins, diabetic retinopathy, anti-TNF therapy, diabetic rats, retinal permeability, endothelial permeability, leukocyte adhesion molecules
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- Xie, M., Zheng, Y., Huang, L., & Xu, G. (2017). Infliximab relieves blood retinal barrier breakdown through the p38 MAPK pathway in a diabetic rat model. International Journal of Ophthalmology. https://doi.org/10.18240/ijo.2017.12.06
