Acute changes in ganglion cell layer thickness in ischemic optic neuropathy compared to optic neuritis using optical coherence tomography
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AIM: To elucidate the changes of different ganglion cell layer (GCL) thinning patterns between the optic neuritis (ON) and non-arteritic anterior ischemic optic neuropathy (NAION). METHODS: A prospective, observational study was conducted to evaluate the timing of GCL changes between acute ON and NAION using optical coherence tomography. RESULTS: Thinning on optical coherence tomography in the NAION group occurs as early as 11d after symptomatic onset of vision loss and follows an altitudinal pattern. The mean superior-inferior GCL thickness difference in the NAION cohort was clinically significant at 5.7 μm in the NAION cohort compared to controls of 0.8 μm (P=0.032), but not significant in the ON group compared to controls with both groups measuring 1.1 μm. Global thinning was significant for the ON group compared to controls at 7.2 μm (P=0.011) but not the NAION group compared to controls at 1.35 μm. CONCLUSION: These findings suggest that future treatments for NAION should be given early, and possibly before 11d in order to prevent GCL and irreversible vision loss.
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Assessing GCIPL thickness maps for patterns of regional macular injury might provide insight into vascular etiologies of optic neuropathy, such as when altitudinal thinning is present, or optic chiasm, optic tract, thalamic and/or retrogeniculate pathology.
“Assessing the GCIPL thickness maps for patterns of regional macular injury might provide insight into vascular etiologies of optic neuropathy, such as when altitudinal thinning is present, or optic chiasm, optic tract, thalamic and/or retrogeniculate pathology. 80 -83”
From The use of optical coherence tomography and visual evoked potentials in the 2024 McDonald diagnostic criteria for multiple sclerosis (2025) · cites this paper as [80]
The Discussion (page not provided) reports altitudinal macular ganglion-cell-layer thinning in non-arteritic anterior ischemic optic neuropathy and says this pattern may help distinguish it from optic neuritis. It does not address whether GCIPL maps provide insight into optic chiasm, optic tract, thalamic, or retrogeniculate pathology, so that extension is unsupported by this paper. (LLM, conf=0.87)
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Research works printed but not linked: 20
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Saidha, S., Green, A. J., Leocani, L., Vidal-Jordana, A., Kenney, R. C., Bsteh, G., Outteryck, O., Thompson, A., Montalban, X., Coetzee, T., et al. (2025) · The Lancet Neurology · doi:10.1016/s1474-4422(25)00275-3 · Cited by 66 · see citing works
- Authors
- MacIntosh, P. W.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- MacIntosh, Peter W.
- Venue
- International Journal of Ophthalmology
- Published
- 2020-01-18
- Volume
- 13
- Issue
- 1
- Pages
- 120-123
- ISSN
- 2222-3959 (ISSN-L)
- 2227-4898
- PMC
- PMC6942958
- OpenAlex
- W2996532655
- Cited by
- 13
- References
- 0
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 2 · 2022: 1 · 2021: 2 · 2020: 1
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- International Journal of Ophthalmology (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Research to Prevent Blindness (P30 EY001792, EY001792)
- National Eye Institute (EY001792, P30EY001792)
- Topics
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Health Sciences › Medicine › Ophthalmology › Retinal and Optic Conditions
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Keywords
- nonarteritic anterior ischemic optic neuropathy, optic neuritis, ganglion cell layer thickness, early treatment timing, blindness prevention
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