The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
A Retrospective Study of Fungal Corneal Ulcers in the South Sharqiyah Region in Oman
Open accessAbstract
OBJECTIVES: To study the incidence, identify the risk factors and determine the predominant microorganisms and treatment regimen of fungal corneal ulcers. METHODS: This was a retrospective analysis of corneal ulcers treated in the Ophthalmology Department of Sur Hospital, Oman, undertaken from January 2004 to December 2007. Medical and microbiology records of thirty two culture proven cases of fungal keratitis were reviewed for risk factors, laboratory findings and response to treatment. RESULTS: Out of the total 242 corneal ulcers, 13.22 % were fungal. Among the 102 culture positive cases, 31.38 % were fungal isolates. Fusarium spp (50%) and Aspergillus spp (34.4%) predominated in the hyaline fungal spectrum. The important risk factors were topical steroid usage in 31.25 % of cases and ocular injury in 25 %. The majority of cases (90.62%) responded to 2% ketoconazole alone or in combination with 0.15% amphotericin B. CONCLUSION: Fungal ulcer remains one of the leading causes of visual disability. Indiscriminate use of topical steroids and ocular trauma are the most important risk factors. Filamentous fungi are common aetiological agents in this region. Topical ketoconazole and amphotericin B were very effective for most of the cases.
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“FK is an infectious corneal disease caused by pathogenic fungi. The fungus can invade and colonize the corneal stroma through defects in the epithelial layer, triggering a host inflammatory responses and corneal tissue necrosis [136].”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [136]
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Cites
Keratomycosis in and around Chandigarh: A five-year study from a north Indian tertiary care hospital
Chander, J., Singla, N., Agnihotri, N., et al. (2008) · Indian Journal of Pathology and Microbiology · doi:10.4103/0377-4929.41700 · Cited by 57
Use of Traditional Eye Medicines by corneal ulcer patients presenting to a hospital in South India.
Prajna, N. V., Pillai, M., Manimegalai, T., et al. (1999) · PubMed · Cited by 55
Agarwal, P. K., Roy, P., Das, A., et al. (2001) · PubMed · Cited by 44
Fungal keratitis in patients with corneal ulcer in Sari, Northern Iran.
Shokohi, T., Dailami, K. N., & Haghighi, T. M. (2006) · PubMed · Cited by 40
Yavaş, G. F., Öztürk, F., Küsbeci, T., et al. (2007) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-007-0687-1 · Cited by 29
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Cited by
From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics
Sun, M., Wang, J., Fan, W., Wang, K., Wang, Y., Zhang, J., Ding, S., Zhang, C., Feng, Z., Wang, Y.-G., et al. (2025) · Materials today. Bio · doi:10.1016/j.mtbio.2025.102537 · Cited by 7
“The fungus can invade and colonize the corneal stroma through defects in the epithelial layer, triggering a host inflammatory responses and corneal tissue necrosis [136].”
Metadata
- Authors
- Idiculla, T., Zachariah, G., Keshav, B., & Basu, S.
- Affiliations
- Ministry of Health (OM)
- ORCID
- Zachariah, George
- Venue
- Sultan Qaboos University medical journal
- Publisher
- Sultan Qaboos University
- Published
- 2009-03-16
- Volume
- 9
- Issue
- 1
- Pages
- 59-62
- ISSN
- 2075-051X (ISSN-L)
- 2075-0528
- PMC
- PMC3074753
- OpenAlex
- W4319334513
- Cited by
- 17
- References
- 5
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 3 · 2016: 2 · 2015: 1
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Sultan Qaboos University medical journal (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- PubMed
- Topics
- Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Ophthalmology › Corneal surgery and disorders
- Keywords
- fungal keratitis, corneal ulcer, Fusarium, Aspergillus, risk factors, topical corticosteroids, ocular trauma, ketoconazole, amphotericin B, antifungal therapy
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- Idiculla, T., Zachariah, G., Keshav, B., & Basu, S. (2009). A Retrospective Study of Fungal Corneal Ulcers in the South Sharqiyah Region in Oman. Sultan Qaboos University medical journal. https://doi.org/10.18295/2075-0528.2763
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