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Protein C-mannosylation: facts and questions.
Open accessAbstract
Among the posttranslational modifications of proteins, glycosylation is probably the most abundant one. Two main types of protein glycosylation have been known for several years, namely N-glycosylation and O-glycosylation. Their biochemical properties, structure and biosynthesis, have been described extensively. Their biological functions are also known for a number of proteins, although in many cases the function remains speculative despite continuous efforts. A few years ago, a new type of protein glycosylation was found, which is different from the above-mentioned ones. It was called C-glycosylation, since the sugar is linked to the protein through a carbon-carbon bond. This article reviews the biochemistry of C-glycosylation, the biosynthetic pathway and structural requirements. Possible biological functions of this modification are also discussed.
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Cited by
Protein Posttranslational Modifications: The Chemistry of Proteome Diversifications
Walsh, C. T., Garneau‐Tsodikova, S., & Gatto, G. J. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200501023 · Cited by 1,604
Protein glycosylation in bacteria: sweeter than ever
Nothaft, H., & Szymanski, C. M. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2383 · Cited by 530
Enzymes in the Synthesis of Glycoconjugates
Schmaltz, R. M., Hanson, S. R., & Wong, C.-H. (2011) · Chemical Reviews · doi:10.1021/cr200113w · Cited by 283
Production of Recombinant Proteins: Challenges and Solutions
Palomares, L. A., Estrada-Mondaca, S., & Ramírez, O. T. (2004) · Recombinant Gene Expression · doi:10.1385/1-59259-774-2:015 · Cited by 256
A metabolome-wide association study of kidney function and disease in the general population
Sekula, P., Goek, O.-N., Quaye, L., Barrios, C., Levey, A. S., Römisch-Margl, W., Menni, C., Yet, I., Gieger, C., Inker, L. A., et al. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014111099 · Cited by 203
Metadata
- Authors
- Furmanek, A., & Hofsteenge, J.
- Venue
- Acta Biochimica Polonica
- Publisher
- Frontiers Media SA
- Published
- 2000-09-30
- Volume
- 47
- Issue
- 3
- Pages
- 781-789
- ISSN
- 0001-527X (ISSN-L)
- 1734-154X
- OpenAlex
- W1978351897
- Cited by
- 167
- References
- 0
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
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