Depletion of intracellular glutathione and increased lipid peroxidation mediate cytotoxicity of hematite nanoparticles in MRC-5 cells.

Radu, Mihaela; Munteanu, Maria Cristina; Petrache, Sorina; Serban, Andreea Iren; Dinu, Diana; Hermenean, Anca; Sima, Cornelia; Dinischiotu, Anca

doi:10.18388/abp.2010_2416

Depletion of intracellular glutathione and increased lipid peroxidation mediate cytotoxicity of hematite nanoparticles in MRC-5 cells.

Particles generated from numerous anthropogenic and/or natural sources, such as crystalline α-Fe₂O₃ nanoparticles, have the potential to damage lung cells. In our study we investigated the effects of these nanoparticles (12.5 µg/ml) on lipid peroxidation and the antioxidative system in MRC-5 lung…