The DNA damage response: balancing the scale between cancer and ageing.
Open accessAbstract
Defects in the DNA damage response often lead to an increased susceptibility to cancer, and so the DDR presents an interesting set of novel therapeutic targets. The maintenance of genomic integrity by the DDR has also been found to be involved in the process of organismal ageing. While the removal of cells containing damaged DNA can be beneficial in the prevention of cancer, it may contribute to both normal and pathological ageing.
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HIV-associated inflammation and/or exposure to nucleoside analogues have been associated with changes in telomere-related and other key biologic pathways.
“HIV-associated inflammation and/or exposure to nucleoside analogues have been associated with changes in these and other key biologic pathways (33–40).”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [36]
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References 76 · Cited by 61
- Authors
- Seviour, E. G., & Lin, S.-Y.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Lin, Shiaw-Yih
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2010-12-16
- Volume
- 2
- Issue
- 12
- Pages
- 900-907
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC3034178
- OpenAlex
- W2142201907
- Cited by
- 61
- References
- 76
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 1 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 3 · 2014: 9 · 2013: 6 · 2012: 18
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Aging (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- DNA damage response, cancer susceptibility, aging, genome stability, therapeutic target, DNA repair deficiency, pathological aging
- MeSH terms
- Age Factors, Aging, Animals, DNA Damage, DNA Repair, Humans, Neoplasms, Signal Transduction, Genomic Instability
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