Uncoupling protein 4 (UCP4) gene variability in neurodegenerative disorders: Further evidence of association in Frontotemporal dementia
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. If validated, the involvement of UCP4 in both FTD and LOAD might indicate interesting shared etiological factors which might give future therapeutic clues.
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Mitochondrial dysfunction, a common hallmark in neurodegenerative diseases, points to mitochondrial uncoupling as a critical player.
“Indeed, mitochondrial dysfunction, a common hallmark in neurodegenerative diseases, points especially to the mitochondrial uncoupling process as a critical player [288].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [288]
Mitochondrial uncoupling has a putative role in stroke, dementia, and depression.
“Indeed, a putative role in stroke, dementia, and depression has been suggested.”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [288]
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References 44 · Cited by 12
- Authors
- Montesanto, A., Crocco, P., Dato, S., Geracitano, S., Frangipane, F., Colao, R., Maletta, R., Passarino, G., Bruni, A. C., & Rose, G.
- Affiliations
- University of Calabria (IT)
- Regional Neurogenetic Centre, ASP CZ, Lamezia Terme, Italy
- Corresponding author
- Rose, Giuseppina
- ORCID
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2018-11-13
- Volume
- 10
- Issue
- 11
- Pages
- 3283-3293
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC6286830
- OpenAlex
- W2900549919
- Cited by
- 12
- References
- 44
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 1
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by
- Locations
- Aging (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archive of Doctoral Theses and Digital Collections (University of Calabria) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- genetic polymorphism, frontotemporal dementia, Alzheimer's disease, neurodegenerative diseases, genetic association, shared etiology
- MeSH terms
- Mitochondrial Uncoupling Proteins, Aged, Aged, 80 and over, Female, Genotype, Humans, Male, Parkinson Disease, Case-Control Studies, Genetic Predisposition to Disease, Frontotemporal Dementia
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