Protein synthesis and quality control in aging
Open accessAbstract
Aging is characterized by the accumulation of damage and other deleterious changes, leading to the loss of functionality and fitness. Age-related changes occur at most levels of organization of a living organism (molecular, organellar, cellular, tissue and organ). However, protein synthesis is a major biological process, and thus understanding how it changes with age is of paramount importance. Here, we discuss the relationships between lifespan, aging, protein synthesis and translational control, and expand this analysis to the various aspects of proteome behavior in organisms with age. Characterizing the consequences of changes in protein synthesis and translation fidelity, and determining whether altered translation is pathological or adaptive is necessary for understanding the aging process, as well as for developing approaches to target dysfunction in translation as a strategy for extending lifespan.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
α-Synuclein-induced abnormal upregulation of TH phosphorylation, combined with reduction of gene transcription by aging and aging-related disorders, accelerates pSer40-TH degradation to reduce total TH protein.
“The α-synuclein-induced abnormal upregulation of TH phosphorylation, combined with the reduction of gene transcription by aging and aging-related disorders [126,127,128,129], results in the acceleration of pSer40-TH degradation to reduce total TH protein (Figure 3).”
From Degradation of Tyrosine Hydroxylase by the Ubiquitin-Proteasome System in the Pathogenesis of Parkinson’s Disease and Dopa-Responsive Dystonia (2020) · cites this paper as [128]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 181 · Cited by 172
- Authors
- Anisimova, A. S., Alexandrov, A. I., Makarova, N. E., Gladyshev, V. N., & Dmitriev, S. E.
- Affiliations
- Lomonosov Moscow State University (RU)
- Russian Academy of Sciences (RU)
- Brigham and Women's Hospital (US)
- Engelhardt Institute of Molecular Biology (RU)
- Corresponding author
- Gladyshev, Vadim N.
- Dmitriev, Sergey E.
- ORCID
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2018-12-18
- Volume
- 10
- Issue
- 12
- Pages
- 4269-4288
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC6326689
- OpenAlex
- W2904330826
- Cited by
- 172
- References
- 181
- Citations by year
- 2026: 15 · 2025: 24 · 2024: 19 · 2023: 32 · 2022: 23 · 2021: 27 · 2020: 27 · 2019: 5
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Aging (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- protein synthesis, translational regulation, translation fidelity, proteome, lifespan extension, quality control
- MeSH terms
- Aging, Gene Expression Regulation, Humans, Protein Biosynthesis, Proteome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
