The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Salidroside ameliorates Parkinson's disease by inhibiting NLRP3-dependent pyroptosis
Open accessAbstract
. We found that Sal could ameliorate MPTP-induced PD symptoms and reduce the levels of IL-1β, IL-18 and Gasdermin D, which are main hallmarks of pyroptosis. Further study indicated that Sal alleviated PD through inhibiting NLRP3-dependent pyroptosis. In conclusion, pyroptosis plays a key role in PD and Sal protects dopaminergic neurons by inhibiting NLRP3-dependent pyroptosis through: (1) indirectly reducing the production of NLRP3, pro-IL-1β and pro-IL-18 by inhibiting TLR4/MyD88/NF-κB signaling pathways, (2) directly suppressing pyroptosis through inhibiting TXNIP/NLRP3/caspase-1 signaling pathways. These results indicated that inhibiting pyroptosis or administration of Sal could be a novel therapeutic strategy for PD.
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Cites
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
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Self-citationThe ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
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Cited by
Pyroptosis in inflammatory diseases and cancer
Rao, Z., Zhu, Y., Yang, P., Chen, Z., Xia, Y., Qiao, C., Liu, W., Deng, H., Li, J., Ning, P., et al. (2022) · Theranostics · doi:10.7150/thno.71086 · Cited by 800
Toll-like receptor-mediated neuroinflammation: relevance for cognitive dysfunctions
Squillace, S., & Salvemini, D. (2022) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2022.05.004 · Cited by 117
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Self-citationSalidroside suppresses proliferation and migration in prostate cancer via the PI3K/AKT pathway
Liu, R.-H., Ma, T.-F., Yang, Q., Xiao, W.-C., Yin, L., Yin, M., Zhang, J.-S., & Wang, C.-H. (2023) · Cancer Biomarkers · doi:10.3233/cbm-220454 · Cited by 14
Metadata
- Authors
- Zhang, X., Zhang, Y., Li, R., Zhu, L., Fu, B., & Yan, T.
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2020-05-19
- Volume
- 12
- Issue
- 10
- Pages
- 9405-9426
- ISSN
- 1945-4589 (ISSN-L)
- OpenAlex
- W3028288561
- Cited by
- 163
- References
- 18
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- green
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