Differential Role of Melatonin in Healthy Brain Aging: A Systematic Review and Meta-Analysis of the SAMP8 Model
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< 0.00001). No differences were found in catalase and superoxide dismutase activities between MT-treated and vehicle-treated groups. Furthermore, nuclear-factor-κB, cyclin-dependent kinase-5, and p53 were regulated by MT administration. MT may improve physiological stability during aging by regulating interactions in brain senescence, but acts differentially on the antioxidant system.
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Evidence is contrasting about the effect of melatonin on regulation of antioxidant enzymes.
“However, contrasting evidence remains about the effect of melatonin on the regulation of antioxidant enzymes [457,463,464,465].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [465]
In vivo, melatonin intake diminishes age-derived inflammation and apoptosis, decreases lipid peroxidation, TBARS, and protein carbonyls, counteracting hippocampal senescence and exerting anti-aging and antioxidant effects on mice brains.
“In vivo, melatonin intake has been reported to diminish age-derived inflammation and apoptosis and to decrease lipid peroxidation, thiobarbituric acid reactive substances and protein carbonyls, thus counteracting hippocampal senescence and exerting an anti-aging and antioxidant effect on mice brains [462,463,464,465].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [465]
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References 99 · Cited by 19
- Authors
- Sumsuzzman, D. M., Khan, Z. A., Choi, J., & Hong, Y.
- Affiliations
- Inje University (KR)
- Biohealth Products Research Center (BPRC), Inje University, Gimhae 50834, Korea
- Corresponding author
- Hong, Yonggeun
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2021-04-02
- Volume
- 13
- Issue
- 7
- Pages
- 9373-9397
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC8064193
- OpenAlex
- W3149785546
- Cited by
- 19
- References
- 99
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 2
- FWCI
- 0.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by
- Locations
- Aging (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- melatonin, brain aging, SAMP8 mice, accelerated aging, oxidative stress, antioxidant enzymes, catalase, superoxide dismutase, NF-κB, cyclin-dependent kinase 5, p53
- MeSH terms
- Aging, Animals, Brain, Disease Models, Animal, Glutathione Peroxidase, Melatonin, Superoxide Dismutase, Cellular Senescence, Oxidative Stress
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