New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary

Schmauck-Medina, Tomas, Molière, Adrian, Lautrup, Sofie, Zhang, Jianying, Chlopicki, Stefan, Madsen, Helena Borland, Cao, Shuqin, Soendenbroe, Casper +13 more·2022·Aging

Cited by (321)

Items 201–300 of 321

  1. Cell loss disrupts mechanical homeostasis to drive retinal pigment epithelium ageing-like phenotype in vitro
    Teodora Piskova, Aleksandra N. Kozyrina, Giedre Astrauskaite, Mohamed H. Elsafi Mabrouk, Sebastian Schepl, Stacy Lok Sze Yam, Ragul Ravithas, Wolfgang Wagner, Massimo Vassalli, Jacopo Di Russo · 2026 · Nature Communications
  2. Rescuing lysosomal/autophagic defects via nanoapproach: implications for lysosomal/autophagic defect-related diseases
    Xiao-ying Huang, Yue Fang, Jie Song, Yuanjing Hao, Yuanyuan Cai, Pengfei Wei, Na Zhang · 2025 · Journal of Zhejiang University SCIENCE B
  3. NAD+ Homeostasis and Autophagy: Integrated Control Through Nutrient Signaling in Yeast and Mammals
    Matilda McDaniel, Lan-Hsuan Lee, Su-Ju Lin · 2025 · Cells
  4. Tissue-specific mitochondrial pathway remodeling linked to longevity in honeybee queens
    Clément Joël Lucien Chevret, José Francisco Echegaray, Alexander Walton, Maryam Lo, Olav Rueppell, Hélène Lemieux · 2026 · PLoS ONE
  5. The case for space as a model of accelerated aging
    Max Manwaring-Mueller, Huixun Du, Taylor R. Valentino, Matías Fuentealba, Alexander Chebykin, Fei Wu, David Furman, Daniel A. Winer · 2026 · Nature Aging
  6. The Hallmarks of aging: Paradigms and scientific progress
    Pablo García‐Barranquero, Víctor J. Luque · 2026 · Ageing Research Reviews
  7. Does young feces make the elderly live better? Application of fecal microbiota transplantation in healthy aging
    YUANYUAN LIAO, Xinsi Li, Qian Li, Yizhong Wang, XIUJUN TAN, TING GONG · 2024 · Biocell
  8. Most genetic roots of fungal and animal aging are hundreds of millions of years old according to phylostratigraphy analyses of aging networks
    Hugo Bonnefous, Jérôme Teulière, François‐Joseph Lapointe, Philippe Lopez, Eric P Bapteste · 2024 · GeroScience
  9. Increased inflammation in older high-pressure glaucoma mice
    Sabrina Reinehr, M Rahim Pamuk, Rudolf Fuchshofer, H. Burkhard Dick, Stephanie Carolin Joachim · 2024 · Neurobiology of Aging
  10. Frontiers in Nondrug Treatment of Sarcopenia: A Review of Pathological Mechanisms and the Latest Treatment Strategies
    Qi‐Fei Kuang, Yu‐Qing Ni, You‐Shuo Liu · 2025 · Aging Medicine
  11. Causal pathway from telomere length to occurrence and 28-day mortality of sepsis: an observational and mendelian randomization study
    Tao Jiang, Xuan Mo, Ruonan Zhan, Yi Zhang · 2023 · Aging
  12. Spreading Senescent Cells’ Burden and Emerging Therapeutic Targets for Frailty
    Serena Marcozzi, Giorgia Bigossi, Maria Elisa Giuliani, Giovanni Lai, Robertina Giacconi, Francesco Piacenza, Marco Malavolta · 2023 · Cells
  13. Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway–UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies
    Heling Wang, Richard C. M. Siow, Tomas Schmauck‐Medina, Jianying Zhang, Per Morten Sandset, Clare Filshie, Øystein Lund, Linda Partridge, Linda Hildegard Bergersen, Lene Juel Rasmussen et al. · 2024 · The Journals of Gerontology Series A
  14. Senotherapeutic effect of Agrimonia pilosa Ledeb. in targeting senescent cells in naturally aged mice
    Tomomichi Watanabe, Misato Yazaki, Tomoaki Yazaki, Megumi Furukawa, Nobuo Izumo · 2024 · Food Bioscience
  15. NAD+ Boosting Strategies
    Jared Rice, Sofie Lautrup, Evandro Fei Fang · 2024 · Sub-cellular biochemistry/Subcellular biochemistry
  16. Preliminary Data on the Senolytic Effects of Agrimonia pilosa Ledeb. Extract Containing Agrimols for Immunosenescence in Middle-Aged Humans: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparison Study
    Yoshiki Shimizu, Shieri Shimodan, Mariko Hayashida, Misato Yazaki, Tsuyoshi Sakurada, Tomomichi Watanabe, Yuri Ishii, Yoshie Hirose, Jiro Saito, Sachiyuki Teramoto · 2025 · Nutrients
  17. Exercise-primed extracellular vesicles improve cell-matrix adhesion and chondrocyte health
    Hirotaka Iijima, Kai Wang, Ella D’Amico, Wan‐Yee Tang, Renee J. Rogers, John M. Jakicic, Fabrisia Ambrosio · 2023 · Research Square
  18. Place of biology of ageing in geriatric medicine
    Éric Boulanger · 2023 · European Geriatric Medicine
  19. Selection for Late Reproduction Leads to Loss of Complex I Mitochondrial Capacity and Associated Increased Longevity in Seed Beetles
    Heather Mast, Pierre Ulrich Blier, Mirko Đorđević, Uroš Savković, Claudia D. Holody, Stephane Louis Bourque, Hélène Lemieux · 2024 · The Journals of Gerontology Series A
  20. On the Gut Microbiome as a Central Player in Aging: Mechanisms and Health Outcomes
    A. A. Melnitskaia, Lubov V. Matchekhina, Ильющенко Анна Константиновна, Irina Dmitrievna Strazhesko · 2024 · Advances in Gerontology
  21. Game changer: Navigating between challenges and hopes in geropharmacology
    Qian Chen, Reid Hartman, Lidia Dankiv, Emily Yan, Lindon Howard Young, Robert Barsotti · 2025 · Advances in pharmacology
  22. T lymphocytes linking autoimmunity and cardiovascular disease in aging
    Enrique Ortega‐Sollero, Ignacio Ruiz‐Fernández, Pilar Martı́n · 2025 · The Journal of Cardiovascular Aging
  23. Cellular senescence in cartilage and bone tissue aging: role in disease development and therapeutic potential
    Н. Г. Плехова, Новикова Полина Андреевна, Tsvetov V. Nikolay · 2025 · Genes and Cells
  24. Portfolio analysis of single-cell RNA-sequencing and transcriptomic data unravels immune cells and telomere-related biomarkers in sepsis
    Dan Chen, Xiyi Huang, Chun Wang, Cheng Zheng, Yunhao Liu · 2025 · Frontiers in Immunology
  25. Sea urchin bioactive compounds: emerging interventions for age-related diseases
    Beatriz Escobar-Doncel, Anastasia Papakosta, Jon Storm‐Mathisen, Evandro Fei Fang · 2025 · Ageing Research Reviews
  26. Human ageing and its discontents: rethinking health, disease and intervention
    Piotr Paweł Chmielewski, Teresa Wysocka, Marek Spaczyński, Paul Edward Mozdziak · 2025 · Medical Journal of Cell Biology
  27. Ageing was never a singular problem in biology: implications for mechanisms, measurements and interventions
    Piotr Paweł Chmielewski · 2026 · Biogerontology
  28. Roles of poly(ADP-ribose) polymerase 1 and mitophagy in progeroid syndromes as well as physiological ageing
    Naoko Suga, Yuka Ikeda, Sayuri Yoshikawa, Satoru Matsuda · 2023 · Exploration of Medicine
  29. Climate Change Adaptation for Healthy Ageing
    Faith Hope Muhonja, Simon Mawulorm Agyemang, Reginald Arthur-Mensah Jnr, Sarra Sghaier · 2024 · Springer eBooks
  30. The role of sleep in the aging processes
    R. I. Isaev, Elen A. Mkhitaryan, M. A. Cherdak, V. V. Vasilevskaya, E. A. Marakhovskaya, Mikhail S. Arbatskiy · 2024 · Problems of Geroscience
  31. Predicting the pro-longevity or anti-longevity effect of model organism genes with enhanced Gaussian noise augmentation-based contrastive learning on protein–protein interaction networks
    Ibrahim Alsaggaf, Alex Alves Freitas, Cen Wan · 2024 · NAR Genomics and Bioinformatics
  32. A brief review on aging and its combination with bibliometric analysis on cellular senescence elimination as part of anti aging strategies
    Indah Hartati, Vita Paramita, Farikha Maharani, Lusiana Lusiana, Laeli Kurniasari · 2025 · AIP conference proceedings
  33. On the Role of Sleep in the Aging Processes
    R. I. Isaev, Elen A. Mkhitaryan, M. A. Cherdak, V. V. Vasilevskaya, E. A. Marakhovskaya, Mikhail S. Arbatskiy · 2024 · Advances in Gerontology
  34. Mitochondrial DNA Copy Number as a Hidden Player in the Progression of Multiple Sclerosis: A Bidirectional Two-Sample Mendelian Randomization Study
    Hani Sabaie, Ali Taghavi Rad, Motahareh Shabestari, Danial Habibi, Toktam Saadattalab, Sahar Seddiq, Amir Hossein Saeidian, Asiyeh Sadat Zahedi, Maryam Sanoie, Hassan Vahidnezhad et al. · 2025 · Molecular Neurobiology
  35. Unraveling the relationship between metabolic syndrome and epigenetic aging: evidence from NHANES 1999-2002 and Mendelian randomization study
    Yujun Zhang, Jiawei Gui, Jingjing Song, Benjie Li, Qixian Wang, Xinmeng Lv, Chong Li, Guoyang Zhang, Zaihua Cheng, Xiao Bo Huang · 2025 · The Journals of Gerontology Series A
  36. Systematic identification of exercise-induced anti-aging processes involving intron retention
    Hayata Kodama, Hirotaka Iijima, Yusuke Matsui · 2025 · The Journals of Gerontology Series A
  37. The Physiology of Aging and Exercise
    Andreia N. Cadar, Jenna M. Bartley · 2024 · Springer eBooks
  38. Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence
    Venkatesh Mallikarjun, Oana Dobre, Mark R. Jackson, Melissa Kidd, Jack Llewellyn, Hamish T. J. Gilbert, Stephen M. Richardson, Joe Swift · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  39. Spermidine Mitigates Immune Cell Senescence, Enhances Autophagy, and Boosts Vaccine Responses in Healthy Older Adults.
    Ghada Alsaleh, Mohammad Ali, Amir Hossein Kayvanjoo, Feng Liu, Sagida Bibi, Lin Luo, Melissa Govender, Miles W. Carroll, Sebastian J. Hofer, Tobias Eisenberg et al. · 2025 · Research Square
  40. ATG-18 drives longevity in an HLH-30—dependent manner
    Tomas Schmauck‐Medina, Alexander S. Anisimov, David H. Meyer, Yue Hu, Zebo Huang, Yue Wu, Samuel J. Taylor, Michael Takla, Michael Robert MacArthur, Sarah Jayne Mitchell et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  41. The gut microbiome as a central player in aging: mechanisms and health outcomes
    A. A. Melnitskaia, Lubov V. Matchekhina, Ильющенко Анна Константиновна, Irina Dmitrievna Strazhesko · 2024 · Problems of Geroscience
  42. Role of mitophagy and mitochondria in aging and cellular senescence
    Xiao Fei Liang, Joanna Poulton, Ana Victoria Lechuga‐Vieco · 2024 · Elsevier eBooks
  43. SENS vs. the hallmarks of aging: competing visions, shared challenges
    Pablo García‐Barranquero, Saúl Pérez‐González · 2025 · Biogerontology
  44. A Digital Image Analysis of the Morphology and Immunolocalization of Catalase and Caspase-3 in the Skin of Adult Male Rats After Treatment with Letrozole and Vitamin C
    Anna Pilutin, Julia Łukasiewicz, Sylwia Rzeszotek, Kamila Misiakiewicz-Has, Aleksandra Wilk · 2025 · International Journal of Molecular Sciences
  45. Inter‐Caste Comparison Reveals a Unique Bioenergetic Signature in Long‐Lived Ant Queens
    Maïly Kervella, Fabrice Bertile, Alexandra Granger‐Farbos, Benoı̂t Pinson, Claire Villette, Dimitri Heintz, Alain Schmitt, Martin Quque, Frédéric Bouillaud, François Criscuolo · 2025 · Molecular Ecology
  46. Redox homeostasis in ferroptosis and aging: a causal role for fard-1 and dhs-25 in Caenorhabditis elegans
    Roberta Pensotti, Barbara Sciandrone, Federica Bovio, Laura Schröter, Silvia Maglioni, Leonie Thewes, Matilde Emma Forcella, Andrea Rossi, Paola Alessandra Fusi, Carsten Berndt et al. · 2025 · Redox Biology
  47. Two-photon in vivo imaging reveals cell type-specific mitophagy dynamic changes in mouse somatosensory cortex during aging
    Beatriz Escobar-Doncel, Xiaoyi Zhang, Åsne Ljøstad, Mario Fernández de la Puebla, Shreyas Balachandra Rao, Synnøve Algrøy Fjeldstad, M. Dahle, Mahmood Reza Amiry-Moghaddam, Magnar Bjørås, Wannan Tang et al. · 2026 · npj Aging
  48. Salvia plebeia R. Br. extract delays cellular senescence and promotes healthy aging via Atg7-dependent autophagy, with rosmarinic acid as a major bioactive constituent
    Yan-Ni He, Shi-Ying Li, Pei Xu, Xing‐Yue Zhou, Jing Zeng, Da-Lian Qin, Geng Xiong, Lu Yu, Wei Ren, An-Guo Wu et al. · 2026 · The Journal of Nutritional Biochemistry
  49. Increasing protein intake without increased physical activity is unlikely to improve muscle health: the new U.S. dietary guidelines
    Grith Westergaard Højfeldt, Paul T. Morgan, Casper Soendenbroe · 2026 · The Journal of Physiology
  50. Ergothioneine: from biosynthesis to sustainable biomanufacturing and health applications
    Junjun Yan, Huaming Dong, Jiaxing Hao, Yuyue Ma, Zhao Guoping, Yanfei Zhang · 2026 · Biotechnology Advances
  51. Partial Cell Reprogramming as a Way to Revitalize Living Systems
    Mariia Shorokhova · 2024 · Cell and Tissue Biology
  52. Personalized epigenetics of aging
    Andrea Maugeri, Martina Barchitta, Giuliana Favara, Roberta Magnano San Lio, Antonella Agodi · 2024 · Elsevier eBooks
  53. Ageing drop by drop: Disturbance of the membrane-less organelle biogenesis as an aging hallmark
    Baraa M. G. A. Saqr, Nikolay O Kotoyants, Semen V. Nesterov, Vladimir D. Manuylov, Guy W. Dayhoff, Alexander V. Fonin, Туроверов Константин Константинович, Irina М. Kuznetsova, Valentin Gordeliy, Nikolay S. Ilyinsky et al. · 2024 · Biochemical and Biophysical Research Communications
  54. En búsqueda de nuevos tratamientos para la fibrosis pulmonar idiopática
    Mariel Maldonado · 2024 · Entretextos (en línea, León, Gto.)/Entretextos
  55. Chronobiological Aspects of Aging, Neurodegeneration, and Inflammation
    Srishti Banerjee, Sandip Das, Nabamita Halder, Sunidhi Bisht, Arunansu Talukdar, Sandipan Ray · 2024 · Progress in inflammation research
  56. Gut Microbiota and Metabolic Biomarkers Associated With Longevity
    Brendha Ketlyn Andrade Silva, Maysa Seabra Cendoroglo, Gisele W. B. Colleoni · 2025 · Nutrition Reviews
  57. Germ cells and the aging niche: a systems approach to reproductive longevity
    Mega Obukohwo Oyovwi, Ejime Agbonifo‐Chijiokwu, Rume Arientare Rotu, Ejayeta Jeroh, Kehinde Henrietta Babawale, Ngozichika Obiageli Keke, Aisuodionoe Eromosele Michael · 2025 · Journal of Assisted Reproduction and Genetics
  58. A Systems Level Explanation for Gompertzian Mortality Patterns is provided by the “Multiple and Inter-dependent Component Cause Model”
    Pernille Yde, Majken K. Jensen, Namiko Mitarai, Samir Bhatt · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  59. Mitochondrial maintenance is involved in the exceptional longevity of reproductive queens of the eusocial ant Lasius niger
    Maïly Kervella, Fabrice Bertile, Alexandra Granger‐Farbos, Benoı̂t Pinson, Alain Schmitt, Martin Quque, Frédéric Bouillaud, François Criscuolo · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  60. Hair Bundle Degeneration is a Key Contributor to Age-Related Vestibular Dysfunction
    Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia R. Bloom, Shu Tu, Benjamin J. Borgmeier, Mi Ζhou, Litao Tao, Bechara Kachar, David Z. Z. He · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  61. Editorial: Targeting the aging mitochondria: mechanisms, methods, and therapeutic strategies
    Zhiquan Li, Konstantinos Palikaras, Yuan Li, Vilhelm A. Bohr · 2025 · Frontiers in Aging Neuroscience
  62. Targeting mitochondria mitigates chemotherapy-induced bone marrow dysfunction
    Tim V. D. van Tienhoven, Johanna Lepland, Anne de Snaijer, Akin Bucakci, Wout Maaskant, Gregory van Beek, Eric M. Bindels, Marc H.G.P. Raaijmakers, Tariq Enver, Valgarður Sigurðsson et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  63. Convergent molecular signatures of ageing and injury in the peripheral nervous system
    Dario Lucas Helbing, Michael Reuter, Emilio Cirri, Therese Dau, Joanna M Kirkpatrick, Amy Stockdale, Alexander Schulz, Nova Oraha, Leopold Böhm, Philipp Koch et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  64. Pengaturan MicroRNA pada Penuaan dan Kanker
    Ana Lucia Ekowati, Havian Daulung Telium · 2023 · Muhammadiyah Journal of Geriatric
  65. Associations between cardiorespiratory fitness and lifestyle-related factors with DNA methylation-based aging clocks in older men: WASEDA’S Health Study
    Takuji Kawamura, Zsolt O. Radak, Hiroki Tabata, Hiroshi Akiyama, Nobuhiro Nakamura, Ryoko Kawakami, Tomoko Ito, Chiyoko Usui, Mátyás Jókai, Ferenc Torma et al. · 2023 · medRxiv
  66. Boosting autophagy in anti-tumor proteasome inhibition-mediated cardiotoxicity
    Eleni‐Dimitra Papanagnou, Sentiljana Gumeni, Ioannis P. Trougakos · 2023 · Aging
  67. The manifestations and interdependence of social and physiological aging in wild female Assamese macaques (Macaca assamensis)
    Baptiste Sadoughi · 2023
  68. Biologisk aldring og det humane genom
    Bjarne Ørskov, Bjarne M. Sigurd, Ingolf Nielsen · 2023 · Ugeskrift for Læger
  69. Metformin Treatment of Macrophages Increases Microvessel Growth in Three-Dimensional Hydrogel Coculture
    Justin Silberman, Michael Olagbiyan, Erika Moore · 2024 · Tissue Engineering Part A
  70. Introduction to aging and age-related disease
    Michael Fossel · 2024 · Elsevier eBooks
  71. Altern als Risikofaktor für das Glaukom
    Carl Erb, Verena Prokosch · 2024 · Klinische Monatsblätter für Augenheilkunde
  72. Partial Cell Reprogramming as a Method of Revitalizing Living Systems
    Mariia Shorokhova · 2023 · Tsitologiya
  73. Deciphering the aging process through single‐cell cytometric technologies
    Lok Ming Tam, Timothy P. Bushnell · 2024 · Cytometry Part A
  74. Lebensstiländerungen im Alter und ihr potenzieller Einfluss auf das primäre Offenwinkelglaukom
    Carl Erb, Clivia Erb, Avaz Kazakov, Gulnara Zh. Kapanova, Burkhard Weisser · 2024 · Klinische Monatsblätter für Augenheilkunde
  75. Cellular Mechanisms of Ageing of Oral Tissues
    Jeremy Lau, Agnieszka M. Frydrych, Omar Kujan · 2024
  76. Impact of COVID-19 on depressive symptoms in older adults: Future perspectives and implications
    Celso Silva, Mónica Lopo Tomaz · 2024 · Applied Psychology Research
  77. Histological Indicators of Aging at the Cellular Level: Cellular Senescence, Fibrosis, and Regenerative Capacity
    Eman Ali Elkordy · 2025 · Journal of Microscopy and Ultrastructure
  78. ИНФЛАМЭЙДЖИНГ И МЕТАБОЛИЧЕСКИЙ СИНДРОМ: МОЛЕКУЛЯРНЫЕ МЕХАНИЗМЫ
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  80. Genetic-Epigenetic Regulatory Mechanisms of Extrachromosomal Circular DNA: Evidence for a Role in Aging and Age-Related Neurodegenerative Disorders
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  82. Methylation levels in keratinocyte basal cells reflect donor age and associate with altered cellular proliferation pathways
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  83. Pfos-Induced Black Liver and Premature Hepatic Aging in Mice: A New Paradigm in Environmental Hepatotoxicology
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  84. The Mitochondrial Deoxyribonucleic Acid Puzzle: Controversies, Challenges, and Critical Perspectives – A Narrative Review
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  85. Anti-aging Drugs
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  86. Stem Cell Therapy
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  87. Age-Related Changes in Neuron–Microglia Interaction Mediated by Fractalkine Under Inflammatory Conditions
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  88. Additional file 1 of Relationships between circulating metabolites and facial skin aging: a Mendelian randomization study
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  89. Additional file 2 of Relationships between circulating metabolites and facial skin aging: a Mendelian randomization study
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  90. Depression, loneliness and quality of life in institutionalised and non-institutionalised older adults in Portugal: A cross-sectional study
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  92. Sodium pentaborate pentahydrate ameliorates inflammaging-like phenotypes by modulating redox status in a -galactose-induced accelerated aging rat model
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  93. Rôle des vésicules extracellulaires endothéliales dans la propagation de signaux pro-sénescents et thrombo-inflammation
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  94. Epigénétique, vieillissement cellulaire et hétérogénéité intra-clonale : le modèle de la Leucémie Myéloïde Chronique
    Benjamin Lebecque · 2023 · theses.fr (ABES)
  95. Same mitochondria, different longevities : what do ants tell us about metabolic ageing ?
    Maïly Kervella · 2023 · theses.fr (ABES)
  96. Étude de l'évolution des interactions moléculaires chez les Eucaryotes par des méthodes de comparaison de réseaux dans le but d'identifier des processus ancestraux partagés associés au vieillissement
    Hugo Bonnefous · 2025 · theses.fr (ABES)
  97. Organelle resilience as a comparative blueprint for longevity
    Domagoj Cikes · 2026 · EMBO Molecular Medicine
  98. Aging below ground: Lifespan-resolved transcriptional dynamics in a dominant soil invertebrate model
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  99. Mitochondrial dysfunction in equine ageing: Current evidence and clinical implications for geroscience
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  100. 1,3-1,6 β-glucans reduce aging hallmarks in multiple organs and rapidly induce mitochondrial biogenesis and autophagy via direct effect on the killifish brain and human neurons
    Letizia Brogi, Baldassare Fronte, Fabrizio Tonelli, Maria Marchese, Federico Cremisi, Alessandro Cellerino · 2026 · bioRxiv (Cold Spring Harbor Laboratory)