Decellularized scaffolds in regenerative medicine
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// Yaling Yu 1,2 , Ali Alkhawaji 3 , Yuqiang Ding 4 and Jin Mei 1,2,4 1 Department of Anatomy, Wenzhou Medical University, Wenzhou, China 2 Institute of Bioscaffold Transplantation and Immunology, Wenzhou Medical University, Wenzhou, China 3 Department of Anatomy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia 4 Institute of Neuroscience, Wenzhou Medical University, Wenzhou, China Correspondence to: Jin Mei, email: // Keywords : decellularized scaffold, extracellular matrix, regeneration, organ, in vivo/in vitro Received : February 24, 2016 Accepted : July 18, 2016 Published : July 29, 2016 Abstract Allogeneic organ transplantation remains the ultimate solution for end-stage organ failure. Yet, the clinical application is limited by the shortage of donor organs and the need for lifelong immunosuppression, highlighting the importance of developing effective therapeutic strategies. In the field of regenerative medicine, various regenerative technologies have lately been developed using various biomaterials to address these limitations. Decellularized scaffolds, derived mainly from various non-autologous organs, have been proved a regenerative capability in vivo and in vitro and become an emerging treatment approach. However, this regenerative capability varies between scaffolds as a result of the diversity of anatomical structure and cellular composition of organs used for decellularization. Herein, recent advances in scaffolds based on organ regeneration in vivo and in vitro are highlighted along with aspects where further investigations and analyses are needed.
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Decellularized ECM may provide additional cues that promote regeneration of damaged tissue, ultimately supporting the organoid transplant and promoting its function.
“Decellularized ECM may also provide additional cues that promote regeneration of damaged tissue, ultimately supporting the organoid transplant and promoting its function66.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [66]
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References 112 · Cited by 113
Research works printed but not linked: 2
- [42]Song JJ Guyette JP Gilpin SE Gabriel G Vacanti JP Ott HC Regeneration and experimental orthotopic transplantation of a bioengineered kidney Nature Medicine 2013 19 646 651 PMC3650107 23584091
- [109]Petersen TH Calle EA Zhao L Lee EJ Gui L Raredon MB Gavrilov K Yi T Zhuang ZW Breuer C Tissue-engineered lungs for in vivo implantation Science 2010 329 538 541 20576850 PMC3640463
- Authors
- Yu, Y., Alkhawaji, A., Ding, Y., & Mei, J.
- Affiliations
- Wenzhou Medical University (CN)
- King Saud bin Abdulaziz University for Health Sciences (SA)
- Institute of Neuroscience, Wenzhou Medical University, Wenzhou, China
- Venue
- Oncotarget
- Publisher
- Impact Journals, LLC
- Published
- 2016-07-29
- Volume
- 7
- Issue
- 36
- Pages
- 58671-58683
- ISSN
- 1949-2553 (ISSN-L)
- PMC
- PMC5295461
- OpenAlex
- W2497656764
- Cited by
- 113
- References
- 112
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 9 · 2023: 7 · 2022: 10 · 2021: 13 · 2020: 17 · 2019: 17 · 2018: 17 · 2017: 5 · 2015: 1
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Oncotarget (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81071576)
- Natural Science Foundation of Zhejiang Province (LY14H050005, LY12H15002)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- decellularized scaffolds, extracellular matrix, organ regeneration, regenerative medicine, biomaterials, in vivo regeneration, in vitro regeneration, organ shortage
- MeSH terms
- Animals, Biocompatible Materials, Brain, Heart, Humans, Kidney, Liver, Lung, Pancreas, Regeneration, Skin Physiological Phenomena, Spinal Cord, Tissue Engineering, Regenerative Medicine, Tissue Scaffolds
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