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Cited by 30Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchGenetic Associations and Epidemiology

INPP5D rs35349669 polymorphism with late-onset Alzheimer's disease: A replication study and meta-analysis

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Jing, Hua, Zhu, Jun-Xia, Wang, Hui-Fu, Zhang, Wei, Zheng, Zhan-Jie, Kong, Ling-Li, Tan, Chen-Chen, Wang, Zi-Xuan +2 more·2016·Oncotarget
DOI 10.18632/oncotarget.12648PMC PMC5342472
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Abstract

// Hua Jing 1,* , Jun-Xia Zhu 1,* , Hui-Fu Wang 1 , Wei Zhang 2 , Zhan-Jie Zheng 3 , Ling-Li Kong 3 , Chen-Chen Tan 1 , Zi-Xuan Wang 1 , Lin Tan 4 and Lan Tan 1,4 1 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, PR China 2 Department of Emergency, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, PR China 3 Department of Geriatric, Qingdao Mental Health Center, Qingdao, PR China 4 College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, PR China * The first two authors should be regarded as co-first authors Correspondence to: Lan Tan, email: // Keywords : Alzheimer’s disease; INPP5D; rs35349669; association study; meta-analysis; Gerotarget Received : May 05, 2016 Accepted : October 02, 2016 Published : October 13, 2016 Abstract Inositol polyphosphate-5-phosphatase ( INPP5D ) was reported to be associated with Alzheimer’s disease (AD) through modulating the inflammatory process and immune response. A recent genome-wide association study discovered a new locus single nucleotide polymorphism (SNP, rs35349669) of INPP5D which was significantly associated with susceptibility to late-onset Alzheimer’s disease (LOAD) in Caucasians. In this study, we investigated the relations between the INPP5D polymorphism rs35349669 and LOAD in Han Chinese population comprising 984 LOAD cases and 1352 healthy controls being matched for age and gender. Our results showed no obvious differences in the genotypic or allelic distributions of rs35349669 polymorphism between LOAD cases and healthy controls (genotype: p = 0.167; allele: p = 0.094). Additionally, when these data were stratified by APOE ε4 status, there are still no evident differences in the genotypic or allelic distributions in APOEε4 carriers ( p > 0.05). Furthermore, meta-analysis of 81964 individuals confirmed that rs35349669 was significantly associated with the risk for LOAD (OR=1.08, 95%CI=1.06-1.11), but the results remained negative in Chinese subgroup (OR=0.77, 95%CI=0.53-1.13). Overall, the current evidence did not indicate that INPP5D rs35349669 polymorphism play a role in the genetic predisposition to LOAD in Chinese population.

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  • A non-coding variant rs35349669 in INPP5D increases the risk for Alzheimer's disease (OR = 1.08, 95% CI = 1.06-1.11).

    “a non-coding variant in inositol polyphosphate-5-phosphatase (INPP5D) has been shown to increase AD risk (rs35349669; odds ratio [OR] = 1.08, 95% confidence interval [CI] = 1.06-1.11).5,7”

    From <i>INPP5D</i> deficiency attenuates amyloid pathology in a mouse model of Alzheimer's disease (2023) · cites this paper as [7]

    The Discussion reports that rs35349669 in INPP5D was associated with increased late-onset Alzheimer’s disease risk in the overall meta-analysis (OR = 1.08, 95% CI = 1.06–1.11), but not in the Chinese subgroup. Our copy does not identify the variant as non-coding, so that part of the claim is unsupported. (LLM, conf=0.85)

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Research works printed but not linked: 19

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Authors
Jing, H., Zhu, J.-X., Wang, H.-F., Zhang, W., Zheng, Z.-J., Kong, L.-L., Tan, C.-C., Wang, Z.-X., Tan, L., & Tan, L.
Affiliations
  • Qingdao University (CN)
  • Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, PR China
  • Qingdao Mental Health Center (CN)
  • Department of Geriatric, Qingdao Mental Health Center, Qingdao, PR China
Corresponding author
Jing, Hua
ORCID
Venue
Oncotarget
Publisher
Impact Journals, LLC
Published
2016-10-13
Volume
7
Issue
43
Pages
69225-69230
ISSN
1949-2553 (ISSN-L)
DOI
10.18632/oncotarget.12648
PMC
PMC5342472
OpenAlex
W2530299997
Cited by
30
References
1
Citations by year
2026: 2 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 1 · 2019: 3 · 2018: 1
FWCI
1.07
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Oncotarget (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Qingdao Key Health Discipline Development Fund
  • National Natural Science Foundation of China (81371406, 81501103, 81371406, 81571245, 81471309, 81371406, 81571245, and 81501103, 81471309, 81571245)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
late-onset Alzheimer's disease, INPP5D, single nucleotide polymorphisms, genetic susceptibility, Han Chinese, APOE ε4, inositol polyphosphate 5-phosphatase, replication study, meta-analysis, genetic association, inflammation, immune response, Alzheimer's disease risk genes
MeSH terms
Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases, Aged, Aged, 80 and over, Alleles, Alzheimer Disease, China, Female, Gene Frequency, Genotype, Humans, Male, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Asian People

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