Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT inhibitor decitabine

Turcan, Sevin, Fabius, Armida W. M., Borodovsky, Alexandra, Pedraza, Alicia, Brennan, Cameron, Huse, Jason, Viale, Agnes, Riggins, Gregory J. +1 more·2013·Oncotarget

Cited by (242)

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  4. Long-term administration of the mutant IDH inhibitor DS-1001b suppresses the growth of IDH1-mutant glioma in vitro and in mouse xenograft models and alters epigenetic profiles
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  7. Isocitrate Dehydrogenase (IDH) Mutation in Gliomas
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  8. The Association Between Oxidative Stress, Cellular Differentiation And Galectins In Human Promyelocytic Leukemia Cells (HL-60)
    James R. Vinnai · 2016 · Scholarship@Western (Western University)
  9. The Plasticity of Stem-Like States in Patient-Derived Tumor Xenografts
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  10. Targeting Mitochondrial Enzymes in Pancreatic Cancer
    Gowru Srivani, Begum Dariya, Afroz Alam, Ganji Purnachandra Nagaraju · 2019 · Springer eBooks
  11. The epigenomic impact of methylation in metabolic dysfunction and cancer
    Cynthia A. Zahnow · 2019 · Elsevier eBooks
  12. Experimental Models of Sinonasal Tumors for Preclinical Testing of Candidate Targeted Therapies
    Helena Codina‐Martínez, Sara Lucila Lorenzo‐Guerra, Virginia N. Cabal, Rocío García‐Marín, Cristina Riobello, Laura Suárez–Fernández, Blanca Vivanco, Verónica Blanco‐Lorenzo, Fernando López, Paula Sánchez‐Fernández et al. · 2023 · Current Otorhinolaryngology Reports
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    Pavle Boskovic, Nathalie Wilke, Peter Lichter, Liliana Francois, Bernhard Radlwimmer · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  14. An overview of current and future treatment options for adults anaplastic oligodendroglial tumors
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    И. С. Брюховецкий, А. С. Брюховецкий, Ю. С. Хотимченко · 2014 · Genes and Cells
  16. Microenvironmental Control of Metastatic Progression
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  17. De las doctrinas de la lotería de Babilonia a la medicina de precisión en los gliomas
    Marcelo Andrés Kauffman · 2016 · Neurología Argentina
  18. Epigenetic dysregulation in brain tumors and neurodevelopment
    Marco M. Hefti, Nadejda M. Tsankova · 2016 · Elsevier eBooks
  19. Cell-based models for studying paediatric high-grade gliomas
    Susanna C. Larsson · 2019 · Gothenburg University Publications Electronic Archive (Gothenburg University)
  20. Molecular Therapy for Oligodendrogliomas
    Julie J. Miller, Patrick Yung Wen · 2019 · Elsevier eBooks
  21. Clinical utility of solid tumor epigenetics
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  22. 7267 函館市西部地区の町並み景観の変貌とその要因に関する研究 : -経年的追跡調査による- 2. 変貌の要因と景観誘導の可能性
    満 森下, 富士夫 足達, 孝博 野口, 圭三 山下 · 1992 · 学術講演梗概集. F, 都市計画, 建築経済・住宅問題, 建築歴史・意匠
  23. WITHDRAWN: DNMT inhibitor (decitabine) attenuates tuberculosis-induced spine injury by modulating the expression of microRNA-155 and matrix metalloproteinase-13 via suppressing the hypermethylation of IDH mutant
    Yi Luo, Wenkun Zhang · 2022 · Biochemical and Biophysical Research Communications · Retracted
  24. Faculty Opinions recommendation of IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives.
    Keith Adam Choate · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  25. Prognostic value of epigenetic markers for canine mast cell cancer
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  26. High-Grade Gliomas in Early Adulthood: A Case-Based Review of Current Molecular Diagnostic Considerations
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  27. Precision neuro-oncology: reality and perspectives
    Jiří Polívka, RASHMI NEGI, Richard Koleják, Jiří Polívka, Pavel Potužník · 2023 · Neurologie pro praxi
  28. Pharmacogenetic and bioengineering approaches to the treatment of glial tumors of the brain
    Igor Bryukhovetskiy, Andrey S. Bryukhovetskiy, Yu. S. Khotimchenko · 2014 · Genes and Cells
  29. Gliomas Difusos do Adulto: Prevalência da Mutação IDH1 em um Hospital Universitário
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  30. Epigenome in gliomas: novel targets for therapy
    Astik Manju Ashesh, Mohd Qasid Lari, Yogend Chaurasia, Ajay Kumar, Dileep Kumar · 2025 · Elsevier eBooks
  31. Additional file 2 of Identification of DNA methylation signatures associated with poor outcome in lower-risk Stage, Size, Grade and Necrosis (SSIGN) score clear cell renal cell cancer
    Louis Y. El Khoury, Fu, Shuang, Ryan A. Hlady, Ryan T. Wagner, Wang, Liguo, Eckel-Passow, Jeanette E., Erik P. Castle, Stanton, Melissa L., Thompson, R. Houston, Parker, Alexander S. et al. · 2021 · Figshare
  32. Metabolic Reprogramming in IDH1/2‑Mutant Gliomas: Redox, Anaplerosis, and Therapeutic Vulnerabilities
    Samin Ghasemi, Mehdi Baloochi · 2025 · The Cancer Review
  33. TUBB2A and TM4SF1 Methylation Define Prognostic Subgroups in Adult-Type Diffuse Glioma
    Tarek Ziad Arabi, Itika Arora, Arshiya Akbar, Naveed Syed Abdul Kareem, Zara Ahmed, Volodymyr Mavrych, Olena Bolgova, Shamsa Hilal Saleh, Firoz Ahmed, Ahmed Abu‐Zaid et al. · 2026 · Cancers
  34. Chemotherapy of low-grade astrocytomas
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  35. Molecular mechanisms of pituitary adenoma tumorigenesis and invasiveness
    Mirella P. Hage · 2018
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  37. Mapping epigenetic alterations across brain tumor hallmarks
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  38. The TET Protein Family in Gliomas: Epigenetic Regulation, Molecular Pathogenesis, and Therapeutic Opportunities
    Angelos Kandilas, Dionisis Leimonis, Ioannis Vasilakis, Elisavet Kosma, Christina Piperi · 2026 · Life
  39. Enzyme−Targeted Therapeutics for Neurological Disorders
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  40. BindingDB Entry 50022624: Limitations of current in vitro models for testing the clinical potential of epigenetic inhibitors for treatment of pediatric ependymoma.
    BindingDB · 2025 · UC San Diego
  41. BindingDB Entry 50043932: Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells.
    BindingDB · 2014 · UC San Diego
  42. BindingDB Entry 50008845: Discovery of DC_H31 as potential mutant IDH1 inhibitor through NADPH-based high throughput screening.
    BindingDB · 2021 · UC San Diego