Noncalcemic 20-hydroxyvitamin D3 inhibits human melanoma growth in in vitro and in vivo models

Skobowiat, Cezary; Oak, Allen S.W.; Kim, Tae-Kang; Yang, Chuan He; Pfeffer, Lawrence M.; Tuckey, Robert C.; Slominski, Andrzej T.

doi:10.18632/oncotarget.14193

Noncalcemic 20-hydroxyvitamin D3 inhibits human melanoma growth in in vitro and in vivo models

A novel pathway of vitamin D3 (D3) metabolism, initiated by C20-hydroxylation of D3 by CYP11A1, has been confirmed to operate in vivo. Its major product, 20(OH)D3, exhibits antiproliferative activity in vitro comparable to that of 1,25(OH)2D3, but is noncalcemic in mice and rats. To further chara…