Molecular pathways and therapeutic targets in lung cancer

Shtivelman, Emma, Hensing, Thomas, Simon, George R., Dennis, Phillip A., Otterson, Gregory A., Bueno, Raphael, Salgia, Ravi·2014·Oncotarget
DOI 10.18632/oncotarget.1891

Cited by (230)

Items 101–200 of 230

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  3. A fluorescent light-up aggregation-induced emission probe for screening gefitinib-sensitive non-small cell lung carcinoma
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  4. miR-4731-5p Enhances Apoptosis and Alleviates Epithelial-Mesenchymal Transition through Targeting RPLP0 in Non-Small-Cell Lung Cancer
    Chang Chang, Meilin Xu · 2022 · Journal of Oncology
  5. Registered report: A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
    Babette Haven, Elysia Heilig, Cristine Donham, Michael Settles, Nicole Vasilevsky, Katherine A. Owen, Reproducibility Project: Cancer Biology · 2016 · eLife
  6. A novel FGFR1-binding peptide exhibits anti-tumor effect on lung cancer by inhibiting proliferation and angiogenesis
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  7. Targeting Lung Cancer With Carvacrol‐Triazole‐Arylidene Hydrazide Hybrids: In Vitro and In Silico Cytotoxicity Assessments
    Furkan Çakır, Şeyma Ateşoğlu, Zeynep Ravza Müderrisoğlu, Firdevs Demirel, Fahri Akbaş, Feyzi Sinan Tokalı, Halil Şenol · 2025 · Chemistry & Biodiversity
  8. High Id1 expression, a generally negative prognostic factor, paradoxically predicts a favorable prognosis for adjuvant paclitaxel plus cisplatin therapy in surgically treated lung cancer patients
    Yu‐Jen Cheng, Yi‐Chen Lee, Wen‐Chin Chiu, Jen‐Wei Tsai, Yu-Han Su, Amos C. Hung, Po‐Chih Chang, Chih–Jen Huang, Chee‐Yin Chai, Shyng‐Shiou F. Yuan · 2014 · Oncotarget
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  10. Induction of Cell Death in Human A549 Cells Using 3-(Quinoxaline-3-yl) Prop-2-ynyl Methanosulphonate and 3-(Quinoxaline-3-yl) Prop-2-yn-1-ol
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  11. Long noncoding RNA SNHG20 regulates cell migration, invasion, and proliferation via the microRNA-19b-3p/RAB14 axis in oral squamous cell carcinoma
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  12. Therapeutic Efficacy Studies on the Monoterpenoid Hinokitiol in the Treatment of Different Types of Cancer
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  13. IKKα Promotes the Progression and Metastasis of Non-Small Cell Lung Cancer Independently of its Subcellular Localization
    Angustias Page, A. Fernández Ortega, Josefa P. Alameda, Manuel Navarro, Jesús María Paramio, Melchor Saiz‐Pardo, Edilia I. Almeida, Pilar Hernández, María Jesús Fernández‐Aceñero, Rosa Ana García-Fernández et al. · 2019 · Computational and Structural Biotechnology Journal
  14. Downregulation of caveolin-1 increased EGFR-TKIs sensitivity in lung adenocarcinoma cell line with EGFR mutation
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  15. Targeted percutaneous microwave ablation at the pulmonary lesion combined with mediastinal radiotherapy with or without concurrent chemotherapy in locally advanced non-small cell lung cancer evaluation in a randomized comparison study
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  16. Epidermal growth factor receptor mutations should be considered as a prognostic factor for survival of patients with pathological fractures or painful bone metastases from non-small cell lung cancer
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  17. MiR ‐630 suppresses non‐small cell lung cancer by targeting vimentin
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  18. Diosgenin promotes cisplatin‐induced apoptosis through oxidative DNA damage in A549 non‐small cell lung cells
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  19. An Anti-EGFR/anti- HER2 Bispecific Antibody with Enhanced Antitumor Activity Against Acquired Gefitinib-Resistant NSCLC Cells
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  20. Effectiveness of Artificial Intelligence Models in Predicting Lung Cancer Recurrence: A Gene Biomarker-Driven Review
    Niloufar Pourakbar, Alireza Motamedi, Mahta Pashapour, Mohammad Emad Sharifi, Seyedemad Seyedgholami Sharabiani, Asra Fazlollahi, Hamid Abdollahi, Arman Rahmim, Sahar Rezaei · 2025 · Cancers
  21. Construction of a prognostic model for lung squamous cell carcinoma based on immune-related genes
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  22. Lung Cancer – Standard Therapy and the Use of a Novel, Highly Effective, Well Tolerated, Treatment With Progesterone Receptor Modulators
    Jerome H. Check, Trina Poretta, DIANE L. CHECK, Maya Devi Srivastava · 2023 · Anticancer Research
  23. HER2-siRNA delivered by EGFR-specific single chain antibody inhibits NSCLC cell proliferation and tumor growth
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  24. Cellular retinol binding protein 1 transfection reduces proliferation and AKT-related gene expression in H460 non-small lung cancer cells
    Amedeo Ferlosio, Elena Doldo, Sara Agostinelli, Gaetana Costanza, Federica Centofanti, Angelo Sidoni, Augusto Orlandi · 2020 · Molecular Biology Reports
  25. Constitutional abnormality of nuclear membrane proteins in small cell lung carcinoma
    Jieying Wang, Tetsuo Kondo, Tadao Nakazawa, Naoki Oishi, Kunio Mochizuki, Ryohei Katoh · 2019 · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
  26. Simultaneous analysis of ALK, RET, and ROS1 gene fusions by NanoString in Brazilian lung adenocarcinoma patients
    Lázaro Antônio Campanha Novaes, Luciane Sussuchi da Silva, Pedro De Marchi, Rodrigo de Oliveira Cavagna, Flávia Escremim de Paula, Maicon Fernando Zanon, Adriane Feijó Evangelista, Eduardo Caetano Albino da Silva, Vinícius Duval da Silva, Letícia Ferro Leal et al. · 2021 · Translational Lung Cancer Research
  27. PenDA, a rank-based method for personalized differential analysis: Application to lung cancer
    Magali Richard, Clémentine Decamps, Florent Chuffart, Elisabeth M. Brambilla, Sophie Rousseaux, Saadi Khochbin, Daniel Jost · 2020 · PLoS Computational Biology
  28. Developments of mass spectrometry-based technologies for effective drug development linked with clinical proteomes
    Noboru Nakayama, Yasuhiko Bando, Tetsuya Fukuda, Takeshi Kawamura, Haruhiko Nakamura, György Marko‐Varga, Toshihide Nishimura · 2015 · Drug Metabolism and Pharmacokinetics
  29. Correlation among genetic variations of c-MET in Chinese patients with non-small cell lung cancer
    Jianchun Duan, Xiaodan Yang, Jun Zhao, Minglei Zhuo, Zhijie Wang, Tongtong An, Hua Bai, Jie Wang · 2017 · Oncotarget
  30. Developments for Personalized Medicine of Lung Cancer Subtypes: Mass Spectrometry-Based Clinical Proteogenomic Analysis of Oncogenic Mutations
    Toshihide Nishimura, Haruhiko Nakamura · 2016 · Advances in experimental medicine and biology
  31. Femoral metastatic pathological fractures, impending and actual fractures – A patient survival study
    Oded Hershkovich, Mojahed Sakhnini, Gal Barkay, Boaz Liberman, Alon Friedlander, Raphael Lotan · 2023 · Surgical Oncology
  32. Establishment of prostate cancer spheres from a prostate cancer cell line after phenethyl isothiocyanate treatment and discovery of androgen-dependent reversible differentiation between sphere and neuroendocrine cells
    Yamei Chen, Shundong Cang, Liying Han, Christina Liu, Patrick W. Yang, Zeeshan Solangi, Quanyi Lu, Delong Liu, Jen-Wei Chiao · 2016 · Oncotarget
  33. Silence of S1 RNA binding domain 1 represses cell growth and promotes apoptosis in human non-small cell lung cancer cells
    Tao Zhang, Guowei Cheng, Lei Deng, Yin Yang, Li Sun, Ping Chen, Xiangling He, Dan Su, Nan Bi, Bin Qiu · 2019 · Translational Lung Cancer Research
  34. FAM136A immunoreactivity is associated with nodal involvement and survival in lung adenocarcinoma in a Chinese case series.
    Liufang Zhao, Chunlei Ge, Zhiwei Zhang, Hongyan Hu, Yi Zhang, Wentao Zhao, Ruilei Li, Baozhen Zeng, Xin Song, Gaofeng Li · 2020 · Bioengineered
  35. CUTL1 induces epithelial-mesenchymal transition in non-small cell lung cancer
    Junfeng Wang, Yanbo Wang, Dawei Sun, Fenghai Ren, Sainan Pang, Shidong Xu · 2017 · Oncology Reports
  36. RAD52 motif‑containing protein�1 promotes non‑small cell lung cancer cell proliferation and survival via cell cycle regulation
    Guihua Xu, Jiya Du, Feng Wang, Fan Zhang, Ruimin Hu, Dejun Sun, Jie Shen · 2018 · Oncology Reports
  37. A network-based pathway-extending approach using DNA methylation and gene expression data to identify altered pathways
    Jie Li, Qiaosheng Eric Zhang, Zhuo Chen, Dechen Xu, Yadong Wang · 2019 · Scientific Reports
  38. Aging-associated alterations in gene regulatory networks associate with risk, prognosis and response to therapy in lung adenocarcinoma
    Enakshi Saha, Marouen Ben Guebila, Viola Fanfani, Katherine Hoff Shutta, Dawn Lisa DeMeo, John F Quackenbush, Camila M. Lopes‐Ramos · 2025 · npj Aging
  39. High NF-E2-related factor 2 expression predicts poor prognosis in patients with lung cancer: a meta-analysis of cohort studies
    Qianlei Yang, Hanyi Deng, Haixuan Xia, Mengchuan Xu, Guo-Tao Pan, Jiayuan Mao, Shasha Tao, Kenzo Yamanaka, Yan An · 2019 · Free Radical Research
  40. Complex Oncological Decision-Making Utilizing Fast-and-Frugal Trees in a Community Setting—Role of Academic and Hybrid Modeling
    Ravi Salgia, Isa Mambetsariev, Tingting Tan, Amanda L. Schwer, Daryl Phillip Pearlstein, Hazem H. Chehabi, Angel Ray Baroz, Jeremy Fricke, Rebecca R. Pharaon, Hannah Romo et al. · 2020 · Journal of Clinical Medicine
  41. GANT61/BI-847325 combination: a new hope in lung cancer treatment
    Abdel Halim M. El-Kishky, Nermine Moussa, Maged W. Helmy, Medhat Haroun · 2022 · Medical Oncology
  42. Gene regulatory Networks Reveal Sex Difference in Lung Adenocarcinoma
    Enakshi Saha, Marouen Ben Guebila, Viola Fanfani, Jonas Fischer, Katherine Hoff Shutta, Panagiotis Mandros, Dawn Lisa DeMeo, John F Quackenbush, Camila M. Lopes‐Ramos · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  43. Identification of genetic associations between acute myocardial infarction and non-small cell lung cancer
    Hao W. Zheng, Jie Wang, Yijia Zheng, Xiaofan Hong, Luxi Wang · 2024 · Frontiers in Molecular Biosciences
  44. The role of Wnt/β-catenin signaling in lung cancer progression and therapy: a comprehensive review
    Fares E.M. Ali, Khalid S.A. Badran, Mostafa S. Abd El‐Maksoud, Islam Mohamed Ibrahim, Hanan S. Althagafy, Emad H. M. Hassanein · 2025 · Medical Oncology
  45. Roles of HMGA proteins in cancer: Expression, pathways, and redundancies
    Vincenzo Giancotti, Palmina Cataldi, Claudio Rizzi · 2016 · Journal of Modern Human Pathology
  46. KIAA1429-mediated RXFP1 attenuates non-small cell lung cancer tumorigenesis via N6-methyladenosine modification
    Zhixiang Zhang, Jipeng Guo, Chongwen Gong, Sai Wu, Yanlei Sun · 2024 · Cancer Biomarkers
  47. Fighting Pancreatic Cancer with a Vaccine-Based Winning Combination: Hope or Reality?
    Silvia Brugiapaglia, Ferdinando Spagnolo, Simona Intonti, Francesco Novelli, Claudia Curcio · 2024 · Cells
  48. Detection of PIK3CA mutations, including a novel mutation of V344G in exon 4, in metastatic lung adenocarcinomas: A retrospective study of 115 FNA cases
    Derek B. Allison, Mohammed T. Lilo, Susan Geddes, Aparna Pallavajjalla, Frederic Barton Askin, Edward Gabrielson, Gang Zheng, Qing Kay Li · 2016 · Cancer Cytopathology
  49. The misuse of distributional assumptions in functional class scoring gene-set and pathway analysis
    Chi-Hsuan Ho, Yu‐Jyun Huang, Ying-Ju Lai, Rajarshi Mukherjee, Chuhsing Kate Hsiao · 2021 · G3 Genes Genomes Genetics
  50. Allium ampeloprasum leaf aqueous extract green-formulated Ag nanoparticles: Determination of anti-human lung cancer and antioxidant effects
    Fuhui Zhang, Jinghao Jia, Xuemin Yao · 2023 · Journal of Engineering Research
  51. COVID-19 Candidate Genes and Pathways Potentially Share the Association with Lung Cancer
    Afnan M. Alnajeebi, Hend F. Alharbi, Walla Alelwani, Nouf Abubakr Babteen, Wafa S. Alansari, Ghalia H. Shamlan, Areej A. Eskandrani · 2021 · Combinatorial Chemistry & High Throughput Screening
  52. Grb2-associated binder 2 silencing impairs growth and migration of H1975 cells via modulation of PI3K-Akt signaling.
    Wen Jie Wang, Kun Mou, Xi Feng Wu, Jin Zhong Zhang, Gang Ren, Jiu De Qi, Yi-Fu Xu, Xin Yao · 2015 · PubMed Central
  53. A probabilistic method for leveraging functional annotations to enhance estimation of the temporal order of pathway mutations during carcinogenesis
    Menghan Wang, Tianxin Yu, Jinpeng Liu, Li Chen, Arnold J. Stromberg, John Lee Villano, Susanne M. Arnold, Chunming Liu, Chi Wang · 2019 · BMC Bioinformatics
  54. Toxicity, Safety, and Pharmacotherapeutic Properties of Ursolic Acid: Current Status, Challenges, and Future Perspectives against Lung Cancer
    Chandrakumar Subramanian, Solaipriya Solairaja, Nageswara Rao Dunna, Sivaramakrishnan Venkatabalasubramanian · 2022 · Current Bioactive Compounds
  55. The Chicago Thoracic Oncology Database Consortium: A Multisite Database Initiative
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  56. A Pathway-Based Kernel Boosting Method for Sample Classification Using Genomic Data
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  57. Impact of country of birth on genetic testing of metastatic lung adenocarcinomas in France: African women exhibit a mutational spectrum more similar to Asians than to Caucasians
    Raphaël Saffroy, Jean‐François Morère, Nelly Bosselut, Pasquale F. Innominato, Jocelyne Hamelin, Jean Trédaniel, Sophie Massé, Véronique Dussaule‐Duchatelle, André J. Balaton, Pierre Validire et al. · 2017 · Oncotarget
  58. Effect of gefitinib on serum EGFR and CYFRA21‑1 in patients with advanced non‑small cell lung cancer
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  59. [Relationship between ID1 and EGFR-TKI Resistance in Non-small Cell Lung Cancer].
    Yuchen Bao, Yinmin Zhao, Bin Chen, Jie Luo, Qinfang Deng, Hui Sun, Boxiong Xie, Songwen Zhou · 2016 · Europe PMC (PubMed Central)
  60. Exosomal PVRL4 Promotes Lung Adenocarcinoma Progression by Enhancing the Generation of Myeloid‐Derived Suppressor Cell‐Secreted TGF ‐β1
    Yahai Liang, Jinmei Li, Lihua Zhang, Jinling Zhou, Meilian Liu, Xiaoxia Peng, Weizhen Zheng, Zhennan Lai · 2024 · Thoracic Cancer
  61. Role of Oxidative Stress and DNA Damage/Repair in Lung Cancer
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  62. Water‐Soluble Curcumin Derivatives Including Aza‐Crown Ether Macrocycles as Enhancers of Their Cytotoxic Activity
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  63. Mechanistic insights into molecular targeted therapy and immunotherapy for lung cancer
    Teresa Vincent, Kunnathur Murugesan Sakthivel, C M Reena Josephine, Roopa Prasad, Chinnadurai Kathirvelan, Pavithra Kumar, Mythili Saravanan, Rajan Radha Rasmi · 2025 · Biochemical and Biophysical Research Communications
  64. Judging pathological assessment in cancer specimens
    Mariana E. Berho, P.A. Bejarano · 2014 · Journal of Surgical Oncology
  65. Vitamin D and Lung Cancer
    Tatiana Shaurova, Mukund Seshadri, Pamela A. Hershberger · 2018 · Elsevier eBooks
  66. [Licochalcone A induces cell cycle arrest in human lung squamous carcinoma cells via the PI3K/Akt signaling pathway].
    X Fan, Jiawei Wang, Li Wang · 2023 · PubMed Central
  67. Analysis and Review of Downregulated Actin Cytoskeletal Proteins in Non-Small Cell Lung Cancer
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  69. Comparative Analysis of Mutation in the Buccal Epithelium and Blood in Patients with Lung Cancer and Healthy People
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    Mingwen Shao, Raghad Ayad Majeed, Najeeb Ullah Khan, Jing Lai · 2026 · Naunyn-Schmiedeberg s Archives of Pharmacology
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  76. Role of Oxidative Stress and DNA Damage/Repair in Lung Cancer
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  88. [Role of PD 0332991 on the Proliferation and Apoptosis of Vascular Endothelial Cells].
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  89. Author response: Registered report: A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
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  90. A general kernel boosting framework integrating pathways for predictive modeling based on genomic data
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  98. Cellular Retinol Binding Protein I transfection in H460 non-small lung carcinoma cells reduces proliferation and AKT-related gene expression
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