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CTGF increases matrix metalloproteinases expression and subsequently promotes tumor metastasis in human osteosarcoma through down-regulating miR-519d

Tsai, Hsiao-Chi, Su, Hong-Lin, Huang, Chun-Yin, Fong, Yi-Chin, Hsu, Chin-Jung, Tang, Chih-Hsin·2014·Oncotarget
DOI 10.18632/oncotarget.1998PMC PMC4116521
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  • CTGF has been shown to induce expression of specific MMPs in several pathophysiological conditions, including MMP-2 in retinal neovascularization and diabetic nephropathy, MMP-2 and MMP-3 in tumor metastasis, and MMP-3 and MMP-13 in osteoarthritis.

    “CTGF has been shown to induce the expression of specific MMPs in several pathophysiological conditions, including MMP-2 in both retinal neovascularization (33) and diabetic nephropathy (34), MMP-2 and MMP-3 in tumor metastasis (35), and MMP-3 and MMP-13 in osteoarthritis (36).”

    From Differential protective effects of connective tissue growth factor against Aβ neurotoxicity on neurons and glia (2017) · cites this paper as [35]

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Research works printed but not linked: 55

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Metadata

Authors
Tsai, H.-C., Su, H.-L., Huang, C.-Y., Fong, Y.-C., Hsu, C.-J., & Tang, C.-H.
Affiliations
  • Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan
  • Department of Orthopaedic Surgery, China Medical University Beigang Hospital, Yun-Lin County, Taiwan
  • School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan
  • Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan
Venue
Oncotarget
Publisher
Impact Journals, LLC
Published
2014-05-21
Volume
5
Issue
11
Pages
3800-3812
ISSN
1949-2553
DOI
10.18632/oncotarget.1998
PMC
PMC4116521
Cited by
78
References
0
Language
en

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