A first in man phase I trial of the oral immunomodulator, indoximod, combined with docetaxel in patients with metastatic solid tumors

Soliman, Hatem H., Jackson, Erica, Neuger, Tony, Dees, E. Claire, Harvey, R. Donald, Han, Hyo, Ismail-Khan, Roohi, Minton, Susan +4 more·2014·Oncotarget

Cited by (180)

Items 101–180 of 180

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  2. Modulating Tumor Immunology by Inhibiting Indoleamine 2,3-Dioxygenase (IDO): Recent Developments and First Clinical Experiences
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  3. Update on targeted therapies for advanced non-small cell lung cancer: nivolumab in context
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  4. 1-Methyl-D-Tryptophan Potentiates TGF-β-Induced Epithelial-Mesenchymal Transition in T24 Human Bladder Cancer Cells
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  5. Fragment-based approach to identify IDO1 inhibitor building blocks
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  9. Combined with interventional therapy, immunotherapy can create a new outlook for tumor treatment
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  10. Metabolic Modulation of Kynurenine Based on Kynureninase-Loaded Nanoparticle Depot Overcomes Tumor Immune Evasion in Cancer Immunotherapy
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  14. Design, synthesis and biological evaluation of exiguamine A analogues as IDO1 inhibitors
    Junmin Dong, Xuan Pan, Ying Yang, Guangyan Zhang, Zhiyan Xiao, Zhanzhu Liu · 2021 · European Journal of Medicinal Chemistry
  15. Harnessing sulfur-doped carbon nanodots conjugated with IDO inhibitors act as a dual-mode breast cancer immunotherapy
    Roberta Cillari, Rita C. Acúrcio, Andreia Pereira Barateiro, Helena F. Florindo, Nicolò Mauro, Gennara Cavallaro · 2025 · Journal of Controlled Release
  16. IDO1-Targeted Therapy Does Not Control Disease Development in the Eµ-TCL1 Mouse Model of Chronic Lymphocytic Leukemia
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  17. The Janus-Faced Nature of Ido1 in Infectious Diseases: Challenges and Therapeutic Opportunities
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  18. Neutropenia and docetaxel exposure in metastatic castration‐resistant prostate cancer patients: A meta‐analysis and evaluation of a clinical cohort
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  19. Breast cancer and immunology: biomarker and therapeutic developments
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  20. Docking Studies and Molecular Dynamic Simulations Reveal Different Features of IDO1 Structure
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  26. Binding Properties of Different Categories of Ido1 Inhibitors: A Microscale Thermophoresis Study
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    Philip T. Sobash, Ravindra B Kolhe, Nagla Abdel Karim, Achuta Kumar Guddati, Anand Jillella, Vamsi K Kota · 2020 · Future Oncology
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  29. Overcoming Therapeutic Resistance by Targeting Cancer Inflammation
    Gregory Lawrence Beatty · 2016 · American Society of Clinical Oncology Educational Book
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  32. Indoleamine 2,3-dioxygenase expression in the prognosis of the localized prostate cancer
    Janaína Mendes Ferreira, Humberto Dellê, Cleber Pinto Camacho, Robson José de Almeida, Sabrina T. Reis, Yves Silva Teles Matos, Amanda M. Ramos Lima, Kátia Ramos Moreira Leite, José Pontes‐Júnior, Miguel Srougi · 2020 · International Urology and Nephrology
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  34. Indoleamine 2,3-dioxygenase 1 in cancer immunotherapy: from small-molecule inhibition to PROTAC-mediated degradation
    Xiuyun Li, Hao Meng, Hefeng Wang, Yujing Zhang, Wanpeng Yu · 2025 · Frontiers in Pharmacology
  35. Bacterial tryptophan metabolites in cancer and atherosclerosis: insights for a role in immune checkpoint inhibition
    Thijs Dormans, Jeffrey Kroon, Elena Rampanelli, Max Nieuwdorp, Nick van Es · 2025 · Essays in Biochemistry
  36. Immunotherapy in gastrointestinal stromal tumors: Current landscape and future horizons
    Stavros P. Papadakos, Alexandra Argyrou, Ioannis Karniadakis, Stamatina Vogli, Stamatios E Theocharis · 2025 · World Journal of Clinical Oncology
  37. Medikamentöse Tumortherapie in der Dermato-Onkologie
    Lucie Heinzerling, Anke Hartmann, Martina Hund, Gerold Schuler · 2013 · Springer eBooks
  38. Indoleamine 2,3-Dioxygenase Activity-Induced Acceleration of Tumor Growth, and Protein Kinases-Related Novel Therapeutics Regimens
    Ayşe Başak Engin, Atilla Engin · 2021 · Advances in experimental medicine and biology
  39. Design, synthesis and evaluation of tryptophan analogues as tool compounds to study IDO1 activity
    Nicholas J. Cundy, Roseanna K. Hare, Tina Tang, Andrew G. Leach, Thomas A. Jowitt, Omar Qureshi, John C. Gordon, Nicholas M. Barnes, Catherine Brady, Emma Lloyd Raven et al. · 2021 · RSC Chemical Biology
  40. Comprehensive analysis of the prognostic value and immunological role of IDO1 gene in pan-cancer
    Kaili Lin, Yongfeng Wang, Fangyu Liu, Taifu You, Xiongxiong Liu, Runzhang Liu, Zeyang Li, Chunyu Zhen, Yunxia Zhang, Xingguang Liu et al. · 2024 · European journal of medical research
  41. Design, Synthesis and Biological Evaluation of Novel 1,2,5-Oxadiazol-3- Carboximidamide Derivatives as Indoleamine 2, 3-Dioxygenase 1 (IDO1) Inhibitors
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  42. Metabolic Stress and Immunity: Nutrient-Sensing Kinases and Tryptophan Metabolism
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  43. Checkpoint Blockade Immunotherapy for Glioblastoma
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  44. Combining immunotherapies to treat non-small cell lung cancer
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  45. Indoleamine 2,3-dioxygenase
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  46. Vaccine Therapy and Immunotherapy for Pancreatic Cancer
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  47. Role of Kynurenine Pathway in HIV/AIDS
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  48. Targeting Leukemia Stem Cells and the Immunological Bone Marrow Microenvironment
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  49. Recent Advancements in Immunotherapy for the Treatment of Metastatic Breast Cancer
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  50. Modulation of the Kynurenine Pathway: A New Approach for Treating Neurodegeneration
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  52. Clinical Trials Targeting the Kynurenine Pathway
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  54. IDO/TDO Inhibition in Cancer
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  55. Overview of Tumor Immunotherapy based on Indoleamine 2,3 Dioxygenase Inhibitors
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  56. Checkpoint inhibition in the fight against cancer: NK cells have some to say in it
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  60. Immune Checkpoint Inhibitors in Gastrointestinal Malignancies
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  61. Translating immune characteristics of metastatic tumors into therapeutic targets for cervical cancer
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  62. Towards the development of HAGE-based vaccines for the treatment of patients with triple negative breast cancers
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