Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer

Zaytseva, Yekaterina Y.; Rychahou, Piotr G.; Le, Anh-Thu; Scott, Timothy L.; Flight, Robert M.; Kim, Ji Tae; Harris, Jennifer; Liu, Jinpeng; Wang, Chi; Morris, Andrew J.; Sivakumaran, Theru A.; Fan, Teresa; Moseley, Hunter; Gao, Tianyan; Lee, Eun Y.; Weiss, Heidi L.; Heuer, Timothy S.; Kemble, George; Evers, Mark

doi:10.18632/oncotarget.25361

Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer

Fatty Acid Synthase (FASN), a key enzyme of de novo lipogenesis, is upregulated in many cancers including colorectal cancer (CRC); increased FASN expression is associated with poor prognosis. Potent FASN inhibitors (TVBs) developed by 3-V Biosciences demonstrate anti-tumor activity in vitro and i…