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Simplify p53: just an activator
Open accessAbstract
‘Simplify your life. ’ In research- contrasting such a popular concept- we are challenged by an ever-expanding plethora of observations and accumulation of knowledge. This leads to the development of increasingly complex models trying to explain all aspects of our world that are subject to scientific endeavor. Recently, a well-known object of study from the life sciences, the tumor suppressor p53, has emerged as an example for which diversity of its apparent functions has actually decreased. p53 has long been described to function as a transcription factor. Initially, the cyclin-dependent kinase inhibitor gene CDKN1A (p21WAF1/CIP1) had been discovered as transcriptionally activated by p53 [1]. Similar to this early observation, many genes were detected to be activated by the tumor suppressor. Often the genes
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The transcription factor p53 itself is solely an activator of transcription.
“The transcription factor p53 itself is solely an activator of transcription. 53, 232”
From Census and evaluation of p53 target genes (2017) · cites this paper as [232]
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References 7 · Cited by 3
Research works printed but not linked: 2
- Menendez, et al. Nat. Rev. Cancer. 2009; 9:724–737.
- Böhlig, et al. J. Biomed. Biotechnol. 2011; 2011:464916.
Metadata
- Authors
- Engeland, K.
- Affiliations
- Leipzig University (DE)
- Corresponding author
- Engeland, Kurt
- ORCID
- Engeland, Kurt
- Venue
- Oncotarget
- Publisher
- Impact Journals, LLC
- Published
- 2014-12-16
- Volume
- 6
- Issue
- 1
- Pages
- 3-4
- ISSN
- 1949-2553 (ISSN-L)
- PMC
- PMC4381574
- OpenAlex
- W1853981280
- Cited by
- 3
- References
- 7
- Citations by year
- 2018: 1 · 2017: 1 · 2016: 1
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Oncotarget (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- p53, transcriptional activation, tumor suppressor, p21, cyclin-dependent kinase inhibitors, gene expression regulation
- MeSH terms
- Humans, Neoplasms, Gene Expression Regulation, Neoplastic, Genes, p53, Tumor Suppressor Protein p53, Computational Biology, Genome-Wide Association Study
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