CoChat
Sign Up
Cited by 19Head and Neck Cancer StudiesCancer, Stress, Anesthesia, and Immune ResponseOral Health Pathology and Treatment

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Antidepressants in association with reducing risk of oral cancer occurrence: a nationwide population-based cohort and nested case-control studies

Open access
Chung, Chia-Min, Kuo, Tzer-Min, Chiang, Shang-Lun, Wang, Zhi-Hong, Hung, Chung-Chieh, Lane, Hsien-Yuan, Liu, Chiu-Shong, Ko, Ying-Chin·2016·Oncotarget
DOI 10.18632/oncotarget.7049PMC PMC4905503
Open this paper in CoChat — free accountOpen PDF

Abstract

// Chia-Min Chung 1, 2 , Tzer-Min Kuo 1 , Shang-Lun Chiang 1, 3 , Zhi-Hong Wang 1 , Chung-Chieh Hung 2, 4 , Hsien-Yuan Lane 2, 4 , Chiu-Shong Liu 5 , Ying-Chin Ko 1, 2 1 Environment-Omics-Disease Research Center, China Medical University Hospital, Taichung, Taiwan 2 Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan 3 Department of Health Risk Management, College of Public Health, China Medical University, Taichung, Taiwan 4 Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan 5 Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan Correspondence to: Ying-Chin Ko, e-mail: ycko0406@gmail.com Keywords: oral cancer, antidepressants, cohort Received: September 08, 2015 Accepted: January 20, 2016 Published: January 28, 2016 ABSTRACT Objectives: Several studies suggested that antidepressant use may increase or decrease the risk of cancer occurrence, depending on specific cancer types. The possible carcinogenic effect of antidepressants has received substantial attention; however, evidence remains inconclusive. Here we investigated associations between the use of antidepressants and occurrences of oral cancer (OC). Methods: Two million samples were randomly collected from the National Health Insurance Research Database in Taiwan, which covers 98% of the total population (23 million). All patients from2000 to 2009 were followed up. We identified 5103 patients newly diagnosed with OC after antidepressants use in addition to 20,412 non-OC matched subjects and 95,452 unmatched non-OC subjects. Results: In nested case control analysis, factors associating with OC, including age [OR = 1.02; 95% confidence interval (CI) = 1.01–1.03) and male (OR = 5.30; 95% CI = 4.92–5.70) were independently associated with increased risk of OC. Based on the functions of antidepressants, antidepressants treatment medications were further classified to investigate risk of OC. Selective serotonin reuptake inhibitors (OR = 0.61; 95% CI = 0.53–0.70) and tricyclic antidepressants (OR = 0.57; 95% CI = 0.52–0.63) were associated with reduced risk of OC. The risk of developing OC among subjects taking antidepressants was less than 26% [hazard ratio (HR) =0.74; 95% CI = 0.68–0.81] in prospective cohort study. The effect of a cumulative duration and dose was a significantly reduced risk of OC. Conclusions: The association between antidepressant use and decreasing OC risk were demonstrated by both prospective and nested case–control studies.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.18632/oncotarget.7049

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The 30-day criterion for antidepressant users is widely accepted in other studies.

    “and this criterion is widely accepted in other studies [40-42].”

    From Risk analysis of use of different classes of antidepressants on subsequent dementia: A nationwide cohort study in Taiwan (2017) · cites this paper as [40]

    In Materials and Methods > Study patients (page unavailable), the paper defines antidepressant exposure as a prescription for at least one month, supporting its use of a roughly 30-day criterion. It does not say that this criterion is widely accepted or used in other studies. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 46

  1. Barbui, 2005, Antidepressant pharmacoepidemiology in a general population sample, Journal of clinical psychopharmacology, 25, 285, 10.1097/01.jcp.0000162815.07442.5a · DOI
  2. Singer, 2003, Trends in Prescribing of Selective Serotonin Reuptake Inhibitors and Other Newer Antidepressant Agents in Adult Primary Care, Primary care companion to the Journal of clinical psychiatry, 5, 153, 10.4088/PCC.v05n0402 · DOI
  3. Shapiro, 2013, Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial, Jama, 309, 1359, 10.1001/jama.2013.2813 · DOI
  4. Wong, 2004, A drug utilisation study of antidepressants in children and adolescents using the General Practice Research Database, Archives of disease in childhood, 89, 1098, 10.1136/adc.2004.064956 · DOI
  5. Rocca, 2013, Age and sex patterns of drug prescribing in a defined American population, Mayo Clinic proceedings, 88, 697, 10.1016/j.mayocp.2013.04.021 · DOI · Paper page
  6. Arthur, 2014, Prescription medication use by Canadians aged 6 to 79, Health reports, 25, 3
  7. Steingart, 2000, Antidepressant medication use and breast cancer risk, American journal of epidemiology, 151, 951, 10.1093/oxfordjournals.aje.a010138 · DOI
  8. Newman, 2003, Antidepressant medications and their association with invasive breast cancer and carcinoma in situ of the breast, Epidemiology, 14, 307, 10.1097/01.EDE.0000050695.99660.D1 · DOI
  9. Boivin, 2002, The effects of tricyclic antidepressants on breast cancer risk, British journal of cancer, 86, 92, 10.1038/sj.bjc.6600013 · DOI
  10. Sloan, 2003, Antidepressant medication use and breast cancer risk: a case-control study, International journal of epidemiology, 32, 961, 10.1093/ije/dyg155 · DOI
  11. Aronson, 2010, A population-based case-control study of Selective Serotonin Reuptake Inhibitors (SSRIs) and breast cancer: the impact of duration of use, cumulative dose and latency, BMC medicine, 8, 90, 10.1186/1741-7015-8-90 · DOI
  12. Rosenberg, 2008, SSRI use and breast cancer risk by hormone receptor status, Breast cancer research and treatment, 109, 527, 10.1007/s10549-007-9664-y · DOI
  13. Cho, 2012, Use of antidepressants and the risk of breast cancer: a meta-analysis, Breast cancer research and treatment, 136, 635, 10.1007/s10549-012-2307-y · DOI
  14. Garcia Rodriguez, 2005, Breast cancer risk among users of antidepressant medications, Epidemiology, 16, 101, 10.1097/01.ede.0000147103.92638.c0 · DOI
  15. Petitti, 2005, Breast cancer risk in a large cohort of female antidepressant medication users, Cancer letters, 221, 61, 10.1016/j.canlet.2004.11.003 · DOI
  16. Collet, 2006, Risk of breast cancer in association with exposure to two different groups of tricyclic antidepressants, Pharmacoepidemiology and drug safety, 15, 689, 10.1002/pds.1233 · DOI
  17. Mandelson, 2011, Colorectal cancer risk in relation to antidepressant medication use, International journal of cancer, 128, 227, 10.1002/ijc.25322 · DOI
  18. Rosenberg, 2009, Antidepressant use and colorectal cancer risk, Pharmacoepidemiology and drug safety, 18, 1111, 10.1002/pds.1808 · DOI
  19. Collet, 2006, Use of antidepressants and risk of colorectal cancer: a nested case-control study, The Lancet Oncology, 7, 301, 10.1016/S1470-2045(06)70622-2 · DOI
  20. Sorensen, 2011, Antidepressant use and colorectal cancer risk: a Danish population-based case-control study, British journal of cancer, 104, 188, 10.1038/sj.bjc.6605911 · DOI
  21. Park, 2012, Meta-analysis: selective serotonin reuptake inhibitors and colon cancer, European journal of gastroenterology & hepatology, 24, 1153, 10.1097/MEG.0b013e328355e289 · DOI
  22. Tiihonen, 2010, Incidence of cancer and antidepressant medication: record linkage study, International journal of cancer, 126, 285, 10.1002/ijc.24537 · DOI
  23. Olsen, 2000, Antidepressant medications and risk for cancer, Epidemiology, 11, 171, 10.1097/00001648-200003000-00015 · DOI
  24. Greenberg, 1998, Psychotropic medication use and risk of epithelial ovarian cancer, Cancer epidemiology, biomarkers & prevention, 7, 697
  25. Muir, 2011, Tricyclic antidepressants and the incidence of certain cancers: a study using the GPRD, British journal of cancer, 104, 193, 10.1038/sj.bjc.6605996 · DOI
  26. Ferlay, 2013, Global estimates of cancer prevalence for 27 sites in the adult population in 2008, International journal of cancer, 132, 1133, 10.1002/ijc.27711 · DOI
  27. Bray, 2015, Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012, International journal of cancer, 136, E359, 10.1002/ijc.29210 · DOI · Paper page
  28. Voloudakis-Baltatzis, 2001, Comparative study of serotonin and bombesin in adenocarcinomas and neuroendocrine tumors of the colon, Ultrastructural pathology, 25, 445, 10.1080/019131201753343485 · DOI
  29. Berk, 2012, New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates--Nrf2 activators and GSK-3 inhibitors, Inflammopharmacology, 20, 127, 10.1007/s10787-011-0111-7 · DOI · Paper page
  30. Hanausek, 2009, Desipramine inhibits the growth of a mouse skin squamous cell carcinoma cell line and affects glucocorticoid receptor-mediated transcription, Molecular carcinogenesis, 48, 1123, 10.1002/mc.20564 · DOI
  31. Barkla, 1982, Influence of inhibitors of serotonin uptake on intestinal epithelium and colorectal carcinomas, British journal of cancer, 46, 260, 10.1038/bjc.1982.191 · DOI
  32. Lourenco, 2002, Stopping smoking: a prospective, randomized, double-blind study comparing nortriptyline to placebo, Chest, 122, 403, 10.1378/chest.122.2.403 · DOI
  33. Hedeker, 2007, Fluoxetine, smoking, and history of major depression: A randomized controlled trial, Journal of consulting and clinical psychology, 75, 85, 10.1037/0022-006X.75.1.85 · DOI
  34. Price, 2014, Efficacy of sequential use of fluoxetine for smoking cessation in elevated depressive symptom smokers, Nicotine & tobacco research, 16, 197, 10.1093/ntr/ntt134 · DOI
  35. Niaura, 2004, Experimenter-defined quit dates for smoking cessation: adherence improves outcomes for women but not for men, Addiction, 99, 378, 10.1111/j.1360-0443.2004.00648.x · DOI
  36. Schuster, 2004, Double-blind placebo-controlled trial of fluoxetine in smoking cessation treatment including nicotine patch and cognitive-behavioral group therapy, The American journal on addictions, 13, 438, 10.1080/10550490490512762 · DOI
  37. Launay, 1997, Effects of past history of major depression on smoking characteristics, monoamine oxidase-A and -B activities and withdrawal symptoms in dependent smokers, Drug and alcohol dependence, 45, 31, 10.1016/S0376-8716(97)01338-0 · DOI
  38. Chiang, 2012, The neoplastic impact of tobacco-free betel-quid on the histological type and the anatomical site of aerodigestive tract cancers, International journal of cancer, 131, E733, 10.1002/ijc.27401 · DOI
  39. Tsai, 1995, Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan, Journal of oral pathology & medicine, 24, 450, 10.1111/j.1600-0714.1995.tb01132.x · DOI
  40. Ko, 2005, Different impact from betel quid, alcohol and cigarette: risk factors for pharyngeal and laryngeal cancer, International journal of cancer, 117, 831, 10.1002/ijc.21237 · DOI
  41. Ko, 2012, Monoamine oxidase A variants are associated with heavy betel quid use, Addiction biology, 17, 786, 10.1111/j.1369-1600.2011.00331.x · DOI
  42. Osman, 2008, Inhibitory effect of acetylcholine on monoamine oxidase A and B activity in different parts of rat brain, Arzneimittel-Forschung, 58, 493
  43. Wolf, 1996, Brain monoamine oxidase A inhibition in cigarette smokers, Proceedings of the National Academy of Sciences of the United States of America, 93, 14065, 10.1073/pnas.93.24.14065 · DOI
  44. Khatoon, 2000, Behavioral and biochemical studies of dichloromethane fraction from the Areca catechu nut, Pharmacology, biochemistry, and behavior, 65, 1, 10.1016/S0091-3057(99)00179-3 · DOI
  45. Chiang, 1997, Taiwan's 1995 health care reform, Health policy, 39, 225, 10.1016/S0168-8510(96)00877-9 · DOI
  46. Chen, 2015, Invasive Cervical Cancer and Antidepressants: A Nationwide Population-Based Study, Medicine, 94, e1866, 10.1097/MD.0000000000001866 · DOI

Cited by

Sorted by citations

Metadata

Authors
Chung, C.-M., Kuo, T.-M., Chiang, S.-L., Wang, Z.-H., Hung, C.-C., Lane, H.-Y., Liu, C.-S., & Ko, Y.-C.
Affiliations
  • China Medical University (TW)
  • China Medical University Hospital (TW)
ORCID
Venue
Oncotarget
Publisher
Impact Journals, LLC
Published
2016-01-28
Volume
7
Issue
10
Pages
11687-11695
ISSN
1949-2553 (ISSN-L)
DOI
10.18632/oncotarget.7049
PMC
PMC4905503
OpenAlex
W2291972362
Cited by
19
References
3
Citations by year
2026: 2 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 3 · 2018: 3 · 2017: 3
FWCI
1.88
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Oncotarget (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • China Medical University Hospital
  • Ministry of Science and Technology, Taiwan (MOST104-2314-B039-002, MOST104-2314-B039-003)
  • China Medical University
  • Division of Materials Research
Topics
  • Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
  • Health Sciences › Dentistry › General Dentistry › Oral Health Pathology and Treatment
Keywords
oral cancer, antidepressants, selective serotonin reuptake inhibitors, tricyclic antidepressants, mirtazapine, cancer risk factors, sex differences in cancer risk, age and cancer risk, Taiwan National Health Insurance Research Database
MeSH terms
Antidepressive Agents, Female, Humans, Male, Middle Aged, Mouth Neoplasms, Risk Factors, Taiwan, Cohort Studies, Case-Control Studies, Databases, Factual

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review