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Cited by 12Bee Products Chemical AnalysisHealthcare and Venom ResearchEssential Oils and Antimicrobial Activity

MECANISMOS INVOLUCRADOS EN LA ACTIVIDAD ANTIOXIDANTE Y ANTIBACTERIANA DEL PROPÓLEOS

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Vargas-Sánchez, R D, Torrescano-Urrutia, G R, Mendoza-Wilson, A M, Vallejo-Galland, B, Acedo-Félix, E, SánchezEscalante, J J, Peñalba-Garmendia MC, M C, Sánchez-Escalante, A·2014·BIOtecnia
DOI 10.18633/bt.v16i1.31
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Abstract

"El propóleos es un producto elaborado por las abejas, que se caracteriza por poseer propiedades antioxidantes y antimicrobianas, las cuales son atribuidas a la presencia de compuestos polifenólicos, principalmente flavonoides. Estos compuestos son de bajo peso molecular y en su estructura química contienen un número variable de grupos hidroxilos. Varios investigadores han reportado que los mecanismos antioxidantes propuestos para estos grupos son mediante secuestro de radicales libres, o actuando como substrato para radicales, tales como superóxido e hidroxilo, y quelación de iones metálicos. Mientras que el mecanismo antimicrobiano involucra la inhibición de ácidos nucleicos y degradación de la membrana citoplasmática."

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  • The antibacterial activity of propolis is attributed to the synergism of phenolic acids and flavonoids, which inhibit nucleic acid synthesis and depolarize the cytoplasmic membrane, leading to bacterial death.

    “The antibacterial activity of propolis has been attributed to the synergism of the phenolic acids and flavonoids in its chemical composition; these molecules inhibit the nucleic acid synthesis and depolarize the cytoplasmic membrane, which leads to bacterial death [18,40,43,44].”

    From Anti-Inflammatory and Histological Analysis of Skin Wound Healing through Topical Application of Mexican Propolis (2023) · cites this paper as [43]

    The Conclusions (p. 6) attribute propolis’s antimicrobial activity to flavonoids and phenolic acids, but describe their interaction as possibly individual or synergistic. The mechanisms section (p. 5) reports inhibition of DNA or RNA synthesis and dissipation of bacterial membrane potential. The claim overstates these findings by presenting synergy and the full sequence leading to bacterial death as an established, general mechanism. (LLM, conf=0.85)

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Research works printed but not linked: 30

  1. Bankova V. 2009. Review: chemical diversity of propolis makes it a valuable source of new biologically active compounds. Journal of ApiProduct and ApiMedical Science. 1(2): 23-28.
  2. Cushnie, T.P .T. y Lamb, A.J. 2005a. Antimicrobial activity of flavonoids. International Journal of Antimicrobial Agents. 26:343-356.
  3. Cushnie, T.P . y Lamb, A.J. 2005b. Detection of galangin-induced cytoplasmic membrane damage in Staphylococcus aureus by measuring potassium loss. Journal of Ethnopharmacology. 101: 243-248.
  4. Das, N.P . y Pereira, T.A. 1990. Effects of flavonoids on thermal autoxidation of palm oil: structure-activity relationships. Journal of the American Oil Chemists' Society. 76(4): 255258.
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  6. Erkoc, S., Erkoc, F. y Keskin, N. 2003. Theoretical investigation of quercetin and its radicals isomers. Journal of Molecular Structure. TEOCHEM. 631:141-146.
  7. Eumkeb, G., Siriwong, S. y Thumanu, K. 2012. Synergistic activity of luteolin and amoxicilin combination against resistant Escherichia coli and mode of action. Journal of Photochemistry and Photobiology. 117: 247-253.
  8. FAO. 1996. Value-added products from beekeeping. Food and Agriculture Organization of the United Nations. Bulletin no. 124. Roma.
  9. Farré, R., Frasquet, I., y Sánchez, A. 2004. El própolis y la salud. Ars Pharmaceutica. 45(1): 23-43.
  10. Geckil, H., Ates, B., Durmaz, G., Erdogan, S. y Yilmaz, I. 2005. Antioxidant, free radical scavenging and metal chelating characteristics of propolis. American Journal of Biochemis- try and Biotechnology. 1(1): 27-31.
  11. Kumazawa, S., Fujimoto, T. y Nakayama, T. 2004. Antioxidant activity and constituents of propolis collected in various areas of Japan. Food Science and Technology Research . 10 (1): 86-92.
  12. Jovanovic, S.V., Steenken, S., Tosic, M., Marjanovic, B. y Simic, M.G. 1994. Flavonoids as antioxidants. Journal of American Chemistry Society. 116: 4846-4851.
  13. Kanaski, J., Aksenova, M., Stoyanova, A. y Butterfield D.A. 2002. Ferulic acid antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: Structure activity studies. The Journal of Nutritional Biochemistry. 13: 273-281.
  14. Kroon, P.A. y Williamson, G. 1999. Hidroxycinnamates in plants and food: current and future perspective. Journal of Food Science and Agriculture. 79: 355-361.
  15. Kumar, N., Anmad, K.K.M., Dang, R. y Husain, A. 2008. Antioxidant and antimicrobial activity of propolis from Tamil Nadu zone. Journal of Medicinal Plants Research. 2(12): 361-364.
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  18. Loliger, J. 1991. The use of antioxidants in foods. In: free radicals and food additives. Aruoma, O.I. y Halliwell, B., Eds. Taylor and Francis, London, UK. pp. 121- 150.
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  23. Orsi, R.O., Sforcin, J.M., Funari, S.R., Junior A.F. y Bankova, V. 2006. Synergistic effect of propolis and antibiotics on the S. typhi. Brazilian Journal of Microbiology. 37: 108-112.
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  25. Pepeljnjak, S. y Kosalec, I. 2004. Galangin expresses bactericidal activity against multiple-resistant bacteria: MRSA, Enterococcus spp. and Pseudomonas aeruginosa . FEMS Microbiology Letters. 240: 111-116.
  26. Sagdic, O., Silici, S. y Yetim, H. 2007. Fate of Escherichia coli and E. coli O157:H7 in apple juice treated with propolis extract. Annals of Microbiology. 57(3): 345-348.
  27. Sato, M., Fujiwara, E. y Tsuchiya. 1996. Flavones with antibacterial activity against cariogenic bacteria. Journal of Ethnopharmacology. 54: 171-176.
  28. Simúth, J., Trnovský, J. y Jeloková, J. 1986. Inhibition of bacterial DNA-dependent RNA polymerases and restriction endonuclease by UV-absorbing components from propolis. Pharmazie. 41(2), 131-132.
  29. Tsuchiya, H., Sato, M. y Miyazaki, T. 1996. Comparative study on the antibacterial activity of phytochemical flavanones against methicillin-resistant Staphylococcus aureus . Journal of Ethnopharmacology. 50:27-34.
  30. Velázquez, C., Navarro, M., Acosta, A., Angulo, A., Dominguez, Z., Robles, R., Robles-Zepeda, R., Lugo, E., Goycoolea, F.M., Velazquez, E.F., Astiazaran, H. y Hernández, J. 2007. Antibacterial and free-radical scavenging activities of Sonoran propolis. Journal of Applied Microbiology. 103: 1747-1756.

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Authors
Vargas-Sánchez, R. D., Torrescano-Urrutia, G. R., Mendoza-Wilson, A. M., Vallejo-Galland, B., Acedo-Félix, E., SánchezEscalante, J. J., Peñalba-Garmendia MC, M. C., & Sánchez-Escalante, A.
Affiliations
Centro de Investigación en Alimentación y Desarrollo (MX)
ORCID
Venue
BIOtecnia
Publisher
Universidad de Sonora
Published
2014-04-30
Volume
16
Issue
1
Pages
32
ISSN
1665-1456 (ISSN-L)
DOI
10.18633/bt.v16i1.31
OpenAlex
W2255788717
Cited by
12
References
0
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2015: 2 · 2014: 1
FWCI
0.99
Type
journal article
Language
es
Open access
Locations
  • BIOtecnia (publishedVersion)
  • Redalyc (Universidad Autónoma del Estado de México) (submittedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Insect Science › Bee Products Chemical Analysis
  • Health Sciences › Medicine › Pharmacology › Healthcare and Venom Research
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
Keywords
propolis, antioxidant activity, antibacterial activity, polyphenols, flavonoids, free radical scavenging, superoxide, hydroxyl radicals, metal chelation, bee products

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