The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
netmeta : An R Package for Network Meta-Analysis Using Frequentist Methods
Open accessAbstract
Network meta-analysis compares different interventions for the same condition, by combining direct and indirect evidence derived from all eligible studies. Network metaanalysis has been increasingly used by applied scientists and it is a major research topic for methodologists. This article describes the R package netmeta, which adopts frequentist methods to fit network meta-analysis models. We provide a roadmap to perform network meta-analysis, along with an overview of the main functions of the package. We present three worked examples considering different types of outcomes and different data formats to facilitate researchers aiming to conduct network meta-analysis with netmeta.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Effects from small studies (potential publication bias) were assessed through visual inspection of contour-enhanced funnel plots and incorporated into assessments of the certainty of the evidence.36 47”
Citations
Cites
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763
Conducting Meta-Analyses in R with the metafor Package
Viechtbauer, W. (2010) · Journal of Statistical Software · doi:10.18637/jss.v036.i03 · Cited by 20,464
Cochrane Handbook for Systematic Reviews of Interventions
(2019) · doi:10.1002/9781119536604 · Cited by 14,828
Statistical Aspects of the Analysis of Data From Retrospective Studies of Disease
(1959) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/22.4.719 · Cited by 14,689
Hutton, B., Salanti, G., Caldwell, D. M., Chaimani, A., Schmid, C. H., Cameron, C., Ioannidis, J. P. A., Straus, S., Thorlund, K., Jansen, J. P., et al. (2015) · Annals of Internal Medicine · doi:10.7326/m14-2385 · Cited by 8,269
Self-citationHow to perform a meta-analysis with R: a practical tutorial
Balduzzi, S., Rücker, G., & Schwarzer, G. (2019) · Evidence Based Mental Health · doi:10.1136/ebmental-2019-300117 · Cited by 5,827
Self-citationSalanti, G., Ades, A. E., & Ioannidis, J. P. A. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.03.016 · Cited by 3,766
Self-citationdplyr: A Grammar of Data Manipulation
Wickham, H., François, R., Henry, L., Müller, K., & Vaughan, D. (2014) · doi:10.32614/cran.package.dplyr · Cited by 3,555
An algorithm for drawing general undirected graphs
Kamada, T., & Kawai, S. (1989) · Information Processing Letters · doi:10.1016/0020-0190(89)90102-6 · Cited by 2,750
Checking consistency in mixed treatment comparison meta-analysis
Dias, S., Welton, N. J., Caldwell, D. M., & Ades, A. E. (2010) · Statistics in Medicine · doi:10.1002/sim.3767 · Cited by 2,521 · cited 3×
“A method to evaluate local inconsistency in each treatment comparison separately is by using the separate indirect from direct evidence (SIDE) method (Dias, Welton, Caldwell, and Ades 2010).”
Graphical tools for network meta-analysis in STATA
Chaimani, A., Higgins, J. P. T., Mavridis, D., Spyridonos, P., & Salanti, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076654 · Cited by 2,473
Self-citationCombination of direct and indirect evidence in mixed treatment comparisons
Lu, G., & Ades, A. E. (2004) · Statistics in Medicine · doi:10.1002/sim.1875 · Cited by 2,172
Consistency and inconsistency in network meta-analysis: concepts and models for multi-arm studies
Higgins, J. P. T., Jackson, D., Barrett, J. K., Lu, G., Ades, A. E., & White, I. R. (2012) · Research Synthesis Methods · doi:10.1002/jrsm.1044 · Cited by 2,098
CINeMA: an approach for assessing confidence in the results of a network meta-analysis
Nikolakopoulou, A., Higgins, J. P. T., Papakonstantinou, T., Chaimani, A., Del Giovane, C., Egger, M., & Salanti, G. (2020) · PLOS Medicine · doi:10.1371/journal.pmed.1003082 · Cited by 1,935
Self-citationRanking treatments in frequentist network meta-analysis works without resampling methods
Rücker, G., & Schwarzer, G. (2015) · BMC Medical Research Methodology · doi:10.1186/s12874-015-0060-8 · Cited by 1,732 · cited 2×
“The notation in this paper follows Schwarzer et al. (2015, Chapter 8).”
Self-citationSalanti, G. (2012) · Research Synthesis Methods · doi:10.1002/jrsm.1037 · Cited by 1,729
Self-citationSchwarzer, G., Carpenter, J. R., & Rücker, G. (2015) · Use R! · doi:10.1007/978-3-319-21416-0 · Cited by 1,230
Self-citationEvaluation of networks of randomized trials
Salanti, G., Higgins, J. P., Ades, A., & Ioannidis, J. P. (2008) · Statistical Methods in Medical Research · doi:10.1177/0962280207080643 · Cited by 1,078
Self-citationGeneralized Inverse of Matrices and Its Applications
Mayne, A. J., Rao, C. R., & Mitra, S. K. (1972) · Operational Research Quarterly (1970-1977) · doi:10.2307/3007981 · Cited by 822
White, I. R. (2015) · The Stata Journal Promoting communications on statistics and Stata · doi:10.1177/1536867x1501500403 · Cited by 789
Stijnen, T., Hamza, T. H., & Özdemir, P. (2010) · Statistics in Medicine · doi:10.1002/sim.4040 · Cited by 757
Network meta‐analysis, electrical networks and graph theory
Rücker, G. (2012) · Research Synthesis Methods · doi:10.1002/jrsm.1058 · Cited by 730
Self-citationRegression and the Moore-Penrose Pseudoinverse
(1972) · Mathematics in Science and Engineering/Mathematics in science and engineering · doi:10.1016/s0076-5392(08)x6167-3 · Cited by 728
van der Ven (2019) · doi:10.12688/f1000research · Cited by 599
Quantifying the impact of between-study heterogeneity in multivariate meta-analyses
Jackson, D., White, I. R., & Riley, R. D. (2012) · Statistics in Medicine · doi:10.1002/sim.5453 · Cited by 577
Multivariate meta‐analysis: Potential and promise
Jackson, D., Riley, R., & White, I. R. (2011) · Statistics in Medicine · doi:10.1002/sim.4172 · Cited by 530
Chaimani, A., & Salanti, G. (2012) · Research Synthesis Methods · doi:10.1002/jrsm.57 · Cited by 521 · cited 3×
“See Chaimani and Salanti (2012) for more details on specifying the order.”
Self-citationA graphical tool for locating inconsistency in network meta-analyses
Krahn, U., Binder, H., & König, J. (2013) · BMC Medical Research Methodology · doi:10.1186/1471-2288-13-35 · Cited by 458
Owen, R. K., Bradbury, N. V., Xin, Y., Cooper, N. J., & Sutton, A. J. (2019) · Research Synthesis Methods · doi:10.1002/jrsm.1373 · Cited by 433
GetReal in network meta-analysis: a review of the methodology
Efthimiou, O., Debray, T. P. A., van Valkenhoef, G., Trelle, S., Panayidou, K., Moons, K. G. M., Reitsma, J. B., Shang, A., Salanti, G., & on behalf of GetReal Methods Review Group (2016) · Research Synthesis Methods · doi:10.1002/jrsm.1195 · Cited by 401
Self-citationSetting Research Priorities to Reduce Almost One Million Deaths from Birth Asphyxia by 2015
Lawn, J. E., Bahl, R., Bergström, S., Bhutta, Z. A., Darmstadt, G. L., Ellis, M., English, M., Kurinczuk, J. J., Lee, A. C., Merialdi, M., et al. (2011) · PLoS Medicine · doi:10.1371/journal.pmed.1000389 · Cited by 366
Welton, N. J., Caldwell, D. M., Adamopoulos, E., & Vedhara, K. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwp014 · Cited by 362
An extended mixed‐effects framework for meta‐analysis
Sera, F., Armstrong, B., Blangiardo, M., & Gasparrini, A. (2019) · Statistics in Medicine · doi:10.1002/sim.8362 · Cited by 340
BUGSnet: an R package to facilitate the conduct and reporting of Bayesian network Meta-analyses
Béliveau, A., Boyne, D. J., Slater, J., Brenner, D. R., & Arora, P. (2019) · BMC Medical Research Methodology · doi:10.1186/s12874-019-0829-2 · Cited by 322
Bayesian Random-Effects Meta-Analysis Using the bayesmeta R Package
Röver, C. (2020) · Journal of Statistical Software · doi:10.18637/jss.v093.i06 · Cited by 310
Rücker, G., & Schwarzer, G. (2014) · Statistics in Medicine · doi:10.1002/sim.6236 · Cited by 219
Self-citationKönig, J., Krahn, U., & Binder, H. (2013) · Statistics in Medicine · doi:10.1002/sim.6001 · Cited by 208
Dose-response meta-analysis of differences in means
Crippa, A., & Orsini, N. (2016) · BMC Medical Research Methodology · doi:10.1186/s12874-016-0189-0 · Cited by 205
Performing Arm-Based Network Meta-Analysis in R with the pcnetmeta Package
Lin, L., Zhang, J., Hodges, J. S., & Chu, H. (2017) · Journal of Statistical Software · doi:10.18637/jss.v080.i05 · Cited by 195
Network meta‐analysis of multicomponent interventions
Rücker, G., Petropoulou, M., & Schwarzer, G. (2020) · Biometrical Journal · doi:10.1002/bimj.201800167 · Cited by 195
Self-citationΠετροπούλου, Μ., Nikolakopoulou, A., Veroniki, A. A., Rios, P. D. L., Vafaei, A., Zarin, W., Gianatsi, M., Sullivan, S. M., Tricco, A. C., Chaimani, A., et al. (2016) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2016.11.002 · Cited by 138
Self-citationGeneralized inverse of the Laplacian matrix and some applications
Gutman, İ., & Xiao, W. (2004) · Bulletin Classe des sciences mathematiques et natturalles · doi:10.2298/bmat0429015g · Cited by 136
Generalized inverse of matrices and its applications
Rao, C. R., & Mitra, S. K. (1971) · CERN Document Server (European Organization for Nuclear Research) · Cited by 128
netmeta: Network Meta-Analysis using Frequentist Methods
Rücker, G., Krahn, U., König, J., Efthimiou, O., Davies, A. L., Papakonstantinou, T., & Schwarzer, G. (2013) · doi:10.32614/cran.package.netmeta · Cited by 117
Self-citationJackson, D., White, I. R., & Riley, R. D. (2013) · Biometrical Journal · doi:10.1002/bimj.201200152 · Cited by 112
Network meta‐analysis of rare events using the Mantel‐Haenszel method
Efthimiou, O., Rücker, G., Schwarzer, G., Higgins, J. P. T., Egger, M., & Salanti, G. (2019) · Statistics in Medicine · doi:10.1002/sim.8158 · Cited by 109
Self-citationStowe, R. L., Ives, N. J., Clarke, C. E., Deane, K. H., van Hilten, Wheatley, K., Gray, R. G., Handley, K., & Furmston, A. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007166.pub2 · Cited by 103
Resolve conflicting rankings of outcomes in network meta‐analysis: Partial ordering of treatments
Rücker, G., & Schwarzer, G. (2017) · Research Synthesis Methods · doi:10.1002/jrsm.1270 · Cited by 94
Self-citationIssues in performing a network meta-analysis
Senn, S. J., Gavini, F., Magrez, D., & Scheen, A. J. (2012) · Statistical Methods in Medical Research · doi:10.1177/0962280211432220 · Cited by 77
Dogliotti, A., Paolasso, E., & Giugliano, R. P. (2013) · Heart · doi:10.1136/heartjnl-2013-304347 · Cited by 65
gemtc: Network Meta-Analysis Using Bayesian Methods
van Valkenhoef, G., & Kuiper, J. (2012) · doi:10.32614/cran.package.gemtc · Cited by 64
Automated drawing of network plots in network meta‐analysis
Rücker, G., & Schwarzer, G. (2015) · Research Synthesis Methods · doi:10.1002/jrsm.1143 · Cited by 54
Self-citationBaker, W. L., Baker, E. L., & Coleman, C. I. (2009) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.29.8.891 · Cited by 54
Designs for Two-Colour Microarray Experiments
Bailey, R. A. (2007) · Journal of the Royal Statistical Society Series C (Applied Statistics) · doi:10.1111/j.1467-9876.2007.00582.x · Cited by 52
Rücker, G., Schmitz, S., & Schwarzer, G. (2020) · Biometrical Journal · doi:10.1002/bimj.201900339 · Cited by 47
Self-citationAlgorithms for Visualizing Large Networks
Hu, Y. (2012) · Chapman & Hall/CRC computational science series/Chapman & Hall/CRC computational science · doi:10.1201/b11644-20 · Cited by 43
Circuits and efficiency in incomplete block designs
Paterson, L. (1983) · Biometrika · doi:10.1093/biomet/70.1.215 · Cited by 41
Generalized Mantel-Haenszel Estimators for K 2 x J Tables
Greenland, S. (1989) · Biometrics · doi:10.2307/2532044 · Cited by 37
Estimating the contribution of studies in network meta-analysis: paths, flows and streams
Papakonstantinou, T., Nikolakopoulou, A., Rücker, G., Chaimani, A., Schwarzer, G., Egger, M., & Salanti, G. (2018) · F1000Research · doi:10.12688/f1000research.14770.3 · Cited by 37
Self-citationGünhan, B. K., Friede, T., & Held, L. (2017) · Research Synthesis Methods · doi:10.1002/jrsm.1285 · Cited by 35
Partial order methodology: a valuable tool in chemometrics
Carlsen, L., & Brüggemann, R. (2013) · Journal of Chemometrics · doi:10.1002/cem.2569 · Cited by 23
The statistical importance of a study for a network meta-analysis estimate
Rücker, G., Nikolakopoulou, A., Papakonstantinou, T., Salanti, G., Riley, R. D., & Schwarzer, G. (2020) · BMC Medical Research Methodology · doi:10.1186/s12874-020-01075-y · Cited by 22
Self-citationcranlogs: Download Logs from the 'RStudio' 'CRAN' Mirror
Csárdi, G. (2015) · doi:10.32614/cran.package.cranlogs · Cited by 18
Network meta‐analysis and random walks
Davies, A. L., Papakonstantinou, T., Nikolakopoulou, A., Rücker, G., & Galla, T. (2022) · Statistics in Medicine · doi:10.1002/sim.9346 · Cited by 13
Self-citationnmadb: Network Meta-Analysis Database API
Papakonstantinou, T. (2019) · doi:10.32614/cran.package.nmadb · Cited by 13
Self-citationbnma: Bayesian Network Meta-Analysis using 'JAGS'
Seo, M., & Schmid, C. H. (2019) · doi:10.32614/cran.package.bnma · Cited by 3
(2014) · Institutional Repository University of Antioquia (University of Antioquia) · doi:10.1371/journal.pone
Flagged first, then by citations
Cited by
Sorted by citations
Noetel, M., Sanders, T., Gallardo-Gómez, D., Taylor, P., del Pozo Cruz, B., van den Hoek, D., Smith, J. J., Mahoney, J., Spathis, J., Moresi, M., et al. (2024) · BMJ · doi:10.1136/bmj-2023-075847 · Cited by 707
Stone, G. W., Christiansen, E. H., Ali, Z. A., Andreasen, L. N., Maehara, A., Ahmad, Y., Landmesser, U., & Holm, N. R. (2024) · The Lancet · doi:10.1016/s0140-6736(23)02454-6 · Cited by 351
McIsaac, D. I., Kidd, G., Gillis, C., Branje, K., Al-Bayati, M., Baxi, A., Grudzinski, A. L., Boland, L., Veroniki, A.-A., Wolfe, D., et al. (2025) · BMJ · doi:10.1136/bmj-2024-081164 · Cited by 168
Lampl, C., MaassenVanDenBrink, A., Amin, F. M., Deligianni, C. I., Gil-Gouveia, R., Jassal, T., Sanchez-Del-Rio, M., Reuter, U., Uluduz, D., Versijpt, J., et al. (2023) · The Journal of Headache and Pain · doi:10.1186/s10194-023-01594-1 · Cited by 161
netmeta: Network Meta-Analysis using Frequentist Methods
Rücker, G., Krahn, U., König, J., Efthimiou, O., Davies, A. L., Papakonstantinou, T., & Schwarzer, G. (2013) · doi:10.32614/cran.package.netmeta · Cited by 117
Self-citation
Metadata
- Authors
- Balduzzi, S., Rücker, G., Nikolakopoulou, A., Papakonstantinou, T., Salanti, G., Efthimiou, O., & Schwarzer, G.
- Affiliations
- University of Freiburg (DE)
- University of Bern (CH)
- ORCID
- Venue
- Journal of Statistical Software
- Publisher
- Foundation for Open Access Statistic
- Published
- 2023
- Volume
- 106
- Issue
- 2
- ISSN
- 1548-7660 (ISSN-L)
- OpenAlex
- W4327640222
- Cited by
- 532
- References
- 67
- Citations by year
- 2026: 221 · 2025: 176 · 2024: 108 · 2023: 27
- FWCI
- 98.70
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Journal of Statistical Software (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Science Foundation
- Deutsche Forschungsgemeinschaft
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (186723, 179158, 180083)
- Topics
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Physical Sciences › Mathematics › Statistics and Probability › Data Analysis with R
- Keywords
- network meta-analysis, frequentist methods, direct and indirect evidence, intervention comparison, statistical software
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review