Untersuchung der Funktionen der beiden switch-Regionen von RhoH bei der inhibitorischen Wirkung von RhoH in Phospholipase C-vermittelten Signalwegen
Open accessAbstract
The atypical Rho-GTPase RhoH has shown altered expression in various forms of cancer. We investigated the structural conditions, especially the switch-regions, of the interaction of RhoH with Rac2, inhibiting the stimulation of the PLCγ¬2 and the PLCβ2, as well as of the suspected Rac2-independent inhibition of the PLC-enzymes by RhoH. Therefore we created different RhoH-mutants, which were subsequently expressed in Cos-7-cells together with a PLC and eventually Rac2, measuring the phosphoinositides produced by the PLC-enzymes.
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- Authors
- Nicola, E.
- Corresponding author
- Nicola, Evelyne
- Venue
- Universität Ulm
- Publisher
- Universität Ulm
- Published
- 2018-07-12
- OpenAlex
- W2890379489
- Cited by
- 0
- References
- 0
- Type
- dissertation
- Language
- en
- Open access
- green
- nbn-resolving.de
- Locations
- OPen Access Repositorium der Universität Ulm (OPARU) (Ulm University) (submittedVersion)
- Universität Ulm, Kommunikations- und Informationszentrum (kiz)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- RhoH, switch regions, Rac2, phospholipase C, PLCγ2, PLCβ2, cancer
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