The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Aquatic persistence of eight pharmaceuticals in a microcosm study
Abstract
The persistence of eight pharmaceuticals from multiple classes was studied in aquatic outdoor field microcosms. A method was developed for the determination of a mixture of acetaminophen, atorvastatin, caffeine, carbarnazepine, levofloxacin, sertraline, sulfamethoxazole, and trimethoprim at μg/L levels from surface water of the microcosms using solid phase extraction and high-performance liquid chromatography-ultraviolet (HPLC-UV) and liquid chromatography tandem mass spectrometry (LC-MS-MS). Half-lives in the field ranged from 1.5 to 82 d. Laboratory persistence tests were performed to determine the relative importance of possible loss processes in the microcosms over the course of the study. Results from dark control experiments suggest hydrolysis was not important in the loss of the compounds. No significant differences were observed between measured half-lives of the pharmaceuticals in sunlight-exposed pond water and autoclaved pond water, which suggests photodegradation was important in limiting their persistence, and biodegradation was not an important loss process in surface water over the duration of the study. Observed photoproducts of several of the pharmaceuticals remained photoreactive, which led to further degradation in irradiated surface waters.
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Cites
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Pharmaceuticals in groundwaters
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Cited by
Patel, M., Kumar, R., Kishor, K., Mlsna, T., Pittman, C. U., & Mohan, D. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00299 · Cited by 2,654
Review of risk from potential emerging contaminants in UK groundwater
Stuart, M., Lapworth, D., Crane, E., & Hart, A. (2012) · Science of The Total Environment · doi:10.1016/j.scitotenv.2011.11.072 · Cited by 801
Occurrence and Fate of Human Pharmaceuticals in the Environment
Monteiro, S. C., & Boxall, A. B. A. (2010) · Reviews of Environmental Contamination and Toxicology · doi:10.1007/978-1-4419-1157-5_2 · Cited by 451
Ranking and prioritization of environmental risks of pharmaceuticals in surface waters
Sanderson, H., Johnson, D. J., Reitsma, T., Brain, R. A., Wilson, C. J., & Solomon, K. R. (2004) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2003.12.006 · Cited by 437
Self-citationAntimicrobial pharmaceuticals in the aquatic environment - occurrence and environmental implications
Felis, E., Kalka, J., Sochacki, A., Kowalska, K., Bajkacz, S., Harnisz, M., & Korzeniewska, E. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172813 · Cited by 437
Metadata
- Authors
- Lam, M. W., Young, C. J., Brain, R. A., Johnson, D. J., Hanson, M. A., Wilson, C. J., Richards, S. M., Solomon, K. R., & Mabury, S. A.
- Venue
- Environmental Toxicology and Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-06-01
- Volume
- 23
- Issue
- 6
- Pages
- 1431-1440
- ISSN
- 0730-7268 (ISSN-L)
- 1552-8618
- OpenAlex
- W2159286451
- Cited by
- 300
- References
- 29
- FWCI
- 8.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lam, M. W., Young, C. J., Brain, R. A., Johnson, D. J., Hanson, M. A., Wilson, C. J., Richards, S. M., Solomon, K. R., & Mabury, S. A. (2004). Aquatic persistence of eight pharmaceuticals in a microcosm study. Environmental Toxicology and Chemistry. https://doi.org/10.1897/03-421
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