The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Toxicity of fluoroquinolone antibiotics to aquatic organisms
Abstract
Toxicity tests were performed with seven fluoroquinolone antibiotics, ciprofloxacin, lomefloxacin, ofloxacin, levofloxacin, clinafloxacin, enrofloxacin, and flumequine, on five aquatic organisms. Overall toxicity values ranged from 7.9 to 23,000 μg/L. The cyanobacterium Microcystis aeruginosa was the most sensitive organism (5-d growth and reproduction, effective concentrations [EC50s] ranging from 7.9 to 1,960 μg/L and a median of 49 μg/L), followed by duckweed (Lemna minor, 7-d reproduction, EC50 values ranged from 53 to 2,470 μg/L with a median of 106 μg/L) and the green alga Pseudokirchneriella subcapitata (3-d growth and reproduction, EC50 values ranged from 1,100 to 22,700 μg/L with a median 7,400 μg/L). Results from tests with the crustacean Daphnia magna (48-h survival) and fathead minnow (Pimephales promelas, 7-d early life stage survival and growth) showed limited toxicity with no-observed-effect concentrations at or near 10 mg/L. Fish dry weights obtained in the ciprofloxacin, levofloxacin, and ofloxacin treatments (10 mg/L) were significantly higher than in control fish. The hazard of adverse effects occurring to the tested organisms in the environment was quantified by using hazard quotients. An estimated environmental concentration of 1 μg/L was chosen based on measured environmental concentrations previously reported in surface water; at this level, only M. aeruginosa may be at risk in surface water. However, the selective toxicity of these compounds may have implications for aquatic community structure.
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Cited by
Antibiotics in the aquatic environment – A review – Part I
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Pharmaceuticals and personal care products (PPCPs) in the freshwater aquatic environment
Ebele, A. J., Abou-Elwafa Abdallah, M., & Harrad, S. (2017) · Emerging Contaminants · doi:10.1016/j.emcon.2016.12.004 · Cited by 2,023
Effluent from drug manufactures contains extremely high levels of pharmaceuticals
Larsson, D. G. J., de Pedro, C., & Paxeus, N. (2007) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2007.07.008 · Cited by 1,612
Contamination of surface, ground, and drinking water from pharmaceutical production
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Fluoroquinolone antibiotics: An emerging class of environmental micropollutants
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Metadata
- Authors
- Robinson, A. A., Belden, J. B., & Lydy, M. J.
- Venue
- Environmental Toxicology and Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-02-01
- Volume
- 24
- Issue
- 2
- Pages
- 423-430
- ISSN
- 0730-7268 (ISSN-L)
- 1552-8618
- OpenAlex
- W2063483776
- Cited by
- 512
- References
- 24
- FWCI
- 8.19
- Type
- journal article
- Language
- en
- Open access
- closed
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