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Cited by 465

The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.

Mercury-selenium compounds and their toxicological significance: Toward a molecular understanding of the mercury-selenium antagonism

Khan, Mohammad A.K., Wang, Feiyue·2009·Environmental Toxicology and Chemistry
DOI 10.1897/08-375.1
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Abstract

The interaction between mercury (Hg) and selenium (Se) is one of the best known examples of biological antagonism, yet the underlying mechanism remains unclear. This review focuses on the possible pathways leading to the Hg-Se antagonism, with an emphasis on the potential Hg-Se compounds that are responsible for the antagonism at the molecular level (i.e., bis[methylmercuric]selenide, methylmercury selenocysteinate, selenoprotein P-bound HgSe clusters, and the biominerals HgSexS1−x). The presence of these compounds in biological systems has been suggested by direct or indirect evidence, and their chemical properties support their potentially key roles in alleviating the toxicity of Hg and Se (at high Hg and Se exposures, respectively) and deficiency of Se (at low Se exposures). Direct analytical evidences are needed, however, to confirm their in vivo presence and metabolic pathways, as well as to identify the roles of other potential Hg-Se compounds. Further studies are also warranted for the determination of thermodynamic properties of these compounds under physiological conditions toward a better understanding of the Hg-Se antagonism in biota, particularly under real world exposure scenarios.

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Metadata

Authors
Khan, M. A. K., & Wang, F.
Venue
Environmental Toxicology and Chemistry
Publisher
Oxford University Press (OUP)
Published
2009-08-01
Volume
28
Issue
8
Pages
1567-1577
ISSN
  • 0730-7268 (ISSN-L)
  • 1552-8618
DOI
10.1897/08-375.1
OpenAlex
W2138359166
Cited by
465
References
80
FWCI
17.00
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Mercury-selenium compounds and their toxicological significance: Toward a molecular understanding of the mercury-selenium antagonism. https://app.cochat.ai/papers/10.1897/08-375.1
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Khan, M. A. K., & Wang, F. (2009). Mercury-selenium compounds and their toxicological significance: Toward a molecular understanding of the mercury-selenium antagonism. Environmental Toxicology and Chemistry. https://doi.org/10.1897/08-375.1

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