Localization of Gingival Overgrowth in Heart Transplant Patients Undergoing Cyclosporin Therapy
Abstract
T his research was aimed at determining and comparing the pattern of localization of both cyclosporin‐induced gingival overgrowth and associated periodontal variables in heart transplant patients. Thirty‐nine patients undergoing cyclosporin treatment were studied for 6 months following transplant surgery. Oral hygiene and gingivitis were evaluated using the Silness‐Löe and Löe‐Silness indices. Gingival overgrowth was measured using a periodontal probe to determine the height of the gingiva at six points per tooth. Statistical hypothesis testing was applied to calculate the significance of the results. Overgrowth average showed a steady and significant growth. The graphs depicting average overgrowth localization, “standard periodontograms,” showed remarkable symmetry, and a significantly anterior mandibular papillary distribution. No overgrowth was observed in edentulous areas. The localization of plaque and gingivitis followed a similar pattern; a highly significant correlation was found with the overgrowth localization pattern. It was concluded that the elimination of plaque is an important preventive measure for cyclosporin‐induced gingival overgrowth, and that tooth or periodontium related factors have a significant impact on its pathogenesis. J Periodontol 1994;65:666–670.
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There is a strong correlation between an increased plaque index and the severity of gingival overgrowth.
“Some authors report plaque elimination as a primary preventive measure for drug-induced gingival overgrowth, as there is a strong correlation between an increased plaque index and the severity of gingival overgrowth [10,11].”
From Sodium Valproate-Induced Gingival Enlargement in a Pediatric Patient: A Case Report With Surgical Intervention (2025) · cites this paper as [10]
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- Authors
- Somacarrera, M. L., Hernández, G., Acero, J., & Moskow, B. S.
- Affiliations
- Universidad Complutense de Madrid (ES)
- Corresponding author
- Somacarrera, M.L.
- Venue
- Journal of Periodontology
- Publisher
- Wiley
- Published
- 1994-07
- Volume
- 65
- Issue
- 7
- Pages
- 666-670
- ISSN
- 0022-3492 (ISSN-L)
- 1943-3670
- OpenAlex
- W2115151514
- Cited by
- 35
- References
- 0
- Citations by year
- 2025: 2 · 2024: 1 · 2020: 3 · 2017: 1 · 2012: 1
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Periodontology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Health Professions › Pharmacy › Oral and gingival health research
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Dentistry › Periodontics › Oral Health Pathology and Treatment
- Keywords
- heart transplant recipients, gingivitis, dental plaque, oral hygiene, edentulous space, immunosuppressive drug adverse effects
- MeSH terms
- Adolescent, Adult, Aged, Analysis of Variance, Child, Dental Plaque, Female, Gingival Hyperplasia, Humans, Male, Middle Aged, Oral Hygiene Index, Heart Transplantation, Cyclosporine, Statistics, Nonparametric
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