Severity of periodontitis and metabolic syndrome: is there an association?
Open accessAbstract
BACKGROUND: Metabolic syndrome (MetS) is a major factor for the occurrence of cardiovascular events. Causal factors for MetS are not well defined or yet unidentified. Preliminary investigations suggest that infections and inflammation may be involved in the etiology of this syndrome. This study aims to estimate the association between the severity of periodontitis (exposure) and MetS (outcome). METHODS: A cross-sectional study was conducted with 419 participants recruited from the Diabetes and Hypertensive Treatment Center, Feira de Santana, Bahia, Brazil. After administration of a questionnaire, general and oral clinical examination and laboratory tests were performed. Diagnosis of periodontitis and MetS was performed according to various criteria. The analysis of the effect of periodontitis on MetS used logistic regression analysis with adjustment for confounders. RESULTS: The prevalence of periodontitis was found to be between 34.61% and 55.37%, depending on the classification definitions used, and the prevalence of MetS ranged from 60.86% to 67.06%. In the group with periodontitis, 14.08% had severe and 41.29% had moderate levels of periodontitis. There was an association between severe periodontitis and MetS after adjustment for sex, age, household density, alcoholic beverage consumption, smoking habit, and cardiovascular disease (odds ratio ORadjusted_6 = 2.11, 95% confidence interval = 1.01 to 4.40, P = 0.05). CONCLUSIONS: The results suggest that periodontitis is associated with MetS, and that MetS prevalence is related to severe periodontitis.
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The finding of higher hypertension prevalence in periodontitis was not confirmed in four studies.
“These findings were not confirmed in four studies.[51][52][53][54]”
From Periodontitis is associated with hypertension: a systematic review and meta-analysis (2020) · cites this paper as [52]
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References 35 · Cited by 52
Research works printed but not linked: 3
- Borges PKO, Gimeno SGA, Tomita NE, Ferreira SR. Prevalence and characteristics associated with meta- bolic syndrome in Japanese-Brazilians with and with- out periodontal disease (in Portuguese). Cad Saude Publica 2007;23:657-668.
- Pihlstrom BL, Ortiz-Campos C, McHugh RB. A random- ized four-years study of periodontal therapy. J Periodontol 1981;52:227-242.
- Rothman KJ. Greenland S, Lash TL. Modern Epidemi- ology, 3rd ed. Philadelphia: Lippincott, Williams & Wilkins; 2008. Correspondence: Dr. Isaac Suzart Gomes-Filho, Avenida Getu ´lio Vargas, 379, Centro, Feira de Santana, Bahia, Brazil 44025-010. Fax: 55-75-3623-0661;
- Authors
- Gomes‐Filho, I. S., das Mercês, M. C., de Santana Passos‐Soares, J., Seixas da Cruz, S., Teixeira Ladeia, A. M., Trindade, S. C., de Moraes Marcílio Cerqueira, E., Freitas Coelho, J. M., Marques Monteiro, F. M., Barreto, M. L., Pereira Vianna, M. I., Nascimento Costa, M. D. C., Seymour, G. J., & Scannapieco, F. A.
- Affiliations
- Universidade Estadual de Feira de Santana (BR)
- Universidade Federal da Bahia (BR)
- University of Otago (NZ)
- University at Buffalo, State University of New York (US)
- Corresponding author
- Gomes‐Filho, Isaac Suzart
- ORCID
- Venue
- Journal of Periodontology
- Publisher
- Wiley
- Published
- 2016-04
- Volume
- 87
- Issue
- 4
- Pages
- 357-366
- ISSN
- 0022-3492 (ISSN-L)
- 1943-3670
- OpenAlex
- W2227696843
- Cited by
- 52
- References
- 35
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 8 · 2021: 12 · 2020: 5 · 2019: 7 · 2018: 6 · 2017: 2 · 2016: 2
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Periodontology (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, other-oa)
- Arca - Repositório Institucional da Fiocruz (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado da Bahia
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- periodontitis, metabolic syndrome, periodontitis severity, periodontitis prevalence, cardiovascular risk, inflammation, diabetes mellitus, hypertension
- MeSH terms
- Brazil, Cross-Sectional Studies, Humans, Periodontitis, Prevalence, Metabolic Syndrome
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