Management of postural orthostatic tachycardia syndrome in the absence of randomized controlled trials
Open accessAbstract
Postural orthostatic tachycardia syndrome (POTS) is a clinical syndrome causing patients to experience light-headedness, palpitations, tremors, and breathlessness upon assuming an upright posture. Despite the absence of available long-term, multicenter, randomized controlled trial data, this literature review aims to concisely present the nonpharmacological and pharmacological interventions that have been used in the treatment of POTS reported to date by cross-sectional studies, cohort studies, and retrospective studies. We attempt to classify treatments as first-, second-, and third-line therapies based on our own experience and available data.
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Exercise and reconditioning is currently considered a first-line treatment for POTS.
“which is currently considered a first line treatment (Kichloo et al., 2021”
From Self-reported symptom burden in postural orthostatic tachycardia syndrome (POTS): A narrative review of observational and interventional studies (2023) · cites this paper as Kichloo et al., 2021
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Knoop, I., Picariello, F., Jenkinson, E., Gall, N., Chisari, C., & Moss-Morris, R. (2023) · Autonomic Neuroscience · doi:10.1016/j.autneu.2022.103052 · Cited by 21 · see citing works
“The aim of this systematic review was to contextualize the symptom burden of POTS, and review factors associated with this burden that may guide future treatments.”
Influential
- Authors
- KICHLOO, A., ALJADAH, M., GRUBB, B., & KANJWAL, K.
- Affiliations
- Central Michigan University (US)
- Medical College of Wisconsin (US)
- University of Toledo Medical Center (US)
- McLaren Greater Lansing (US)
- Corresponding author
- KANJWAL, KHALIL
- Venue
- Journal of Innovations in Cardiac Rhythm Management
- Publisher
- MediaSphere Medical LLC
- Published
- 2021-07-01
- Volume
- 12
- Issue
- 7
- Pages
- 4607-4612
- ISSN
- 2156-3977 (ISSN-L)
- 2156-3993
- PMC
- PMC8313187
- OpenAlex
- W3184017963
- Cited by
- 15
- References
- 12
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 2
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Journal of Innovations in Cardiac Rhythm Management (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Keywords
- postural orthostatic tachycardia syndrome, non-pharmacological treatment, pharmacotherapy, first-line therapy, second-line therapy, third-line therapy, treatment classification, autonomic dysfunction
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