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Cited by 43Facial Rejuvenation and Surgery TechniquesBreast Implant and ReconstructionHydrogels: synthesis, properties, applications

An update review on recent skin fillers

Open access
Cheng, Li-Ying, Sun, Xiao-Ming, Tang, Meng-Yao, Jin, Rong, Cui, Wen-Guo, Zhang, Yu-Guang·2016·Plastic and Aesthetic Research
DOI 10.20517/2347-9264.2015.124
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Abstract

Facial rejuvenation has changed over the last decade, evolving from the rhytidectomy to an approach that focuses on revolumization, due to a more complete understanding of the changes to bone and soft tissue that occur with the aging face.Soft tissue augmentation using various injectable filler agents has gained popularity due to their nonsurgical, non-invasive procedures, instant cosmetic outcomes and limited recovery time.The skin filler market is booming and the variety of available skin fillers is increasing, providing the plastic surgeons many choices.Nonpermenant, biodegradable, resorbable agents may induce little complications, but they will normally disappear soon after injection.Semipermenant, biodegradable, biostimulary, nonresorbable fillers may induce a bit more complications, but they will normally disappear spontaneously in a few months.Permanent, nonresorbable fillers usually give rise to severe complications or reactions which may not disappear spontaneous.They may appear several years after the injection, and treatment is often insufficient.Unfortunately, the ideal filler with lasting effect but without any complication has not been discovered yet.In this review, we give an update on currently available skin filler agents, and what is new in recent 5 years.

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  • Alternative biological source approaches for PDRN production tend to be more complex.

    “although these approaches tend to be more complex”

    From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [163]

    The Platelet-rich plasma section describes preparing PRP from blood, not producing PDRN. Searches for PDRN, polydeoxyribonucleotide, alternative biological sources, and production complexity found no passage addressing the claim in our copy; page numbers were not available. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

  • Products from alternative biological source approaches for PDRN production are often safeguarded by patents.

    “and the products are often safeguarded by patents [134,163,164]”

    From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [163]

    The Platelet-rich plasma section discusses PRP preparation and cosmetic use, not PDRN production. Searches for PDRN, alternative biological sources, and patents found no passage addressing whether such products are patented; the paper’s full-text copy is not marked as truncated. (LLM, conf=0.75)

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  • Alternative biological sources such as plants, algae, and sea cucumbers have been explored for PDRN production.

    “Alternative approaches using biological sources such as plants, algae, and sea cucumbers have also been explored for PDRN production”

    From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [163]

    The review’s Platelet-rich plasma and Human-derived bioengineered collagen implants sections discuss other materials, not PDRN production. Searches for PDRN, polydeoxyribonucleotide, and plants, algae, or sea cucumbers found no passage addressing the claimed sources; page numbers were unavailable in our copy. (LLM, conf=0.76)

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Sorted by citations

Authors
Cheng, L.-Y., Sun, X.-M., Tang, M.-Y., Jin, R., Cui, W.-G., & Zhang, Y.-G.
Affiliations
Shanghai Jiao Tong University (CN)
Venue
Plastic and Aesthetic Research
Publisher
OAE Publishing Inc.
Published
2016-03-23
Volume
3
Issue
3
Pages
92
ISSN
  • 2347-9264 (ISSN-L)
  • 2349-6150
DOI
10.20517/2347-9264.2015.124
OpenAlex
W2334901570
Cited by
43
References
1
Citations by year
2026: 3 · 2025: 2 · 2024: 5 · 2023: 8 · 2022: 4 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 1 · 2017: 1 · 2016: 2
FWCI
3.62
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
Plastic and Aesthetic Research (publishedVersion, cc-by-nc-sa)
Topics
  • Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
  • Health Sciences › Medicine › Surgery › Breast Implant and Reconstruction
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
Keywords
facial rejuvenation, soft tissue augmentation, dermal fillers, facial aging, filler complications, biodegradable fillers, permanent fillers, facial volumization

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