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PreprintCited by 27Protein Kinase Regulation and GTPase SignalingCellular transport and secretionHippo pathway signaling and YAP/TAZ

Functions of Rhotekin, an Effector of Rho GTPase, and its Binding Partners in Mammals

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Ito, Hidenori, Morishita, Rika, Nagata, Koh-ichi·2018·International Journal of Molecular Sciences
DOI 10.20944/preprints201805.0395.v1PMC PMC6073136

Preprint — published as 10.3390/ijms19072121

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Abstract

Rhotekin is an effector protein for small GTPase Rho. This protein consists of a Rho binding domain (RBD), a pleckstrin homology (PH) domain, proline-rich regions and a C-terminal PDZ-binding motif. We and other groups have identified various binding partners for Rhotekin and proposed their possible physiological roles. However, functions of Rhotekin per se are largely unknown and information about its physiological roles are fragmentary. In this review, we summarize known features of Rhotekin in neuronal tissues and cancer cells. We also describe characteristics of binding partners for Rhotekin and predicted roles of their interaction.

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  • Rhotekin binds GTP-bound RhoA and inhibits both the intrinsic and GAP-enhanced GTPase activity of RhoA.

    “Interestingly, the RhoA scaffold effector protein Rhotekin binds GTP-bound RhoA and inhibits both the intrinsic and GAP-enhanced GTPase activity of RhoA; this is why it is widely used in pull-down assays for activated RhoA [31].”

    From RhoA Signaling in Neurodegenerative Diseases (2022) · cites this paper as [31]

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Cited by

Sorted by citations

Authors
Ito, H., Morishita, R., & Nagata, K.-I.
Affiliations
Aichi Human Service Center (JP)
Corresponding author
Nagata, Koh-ichi
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2018-05-28
Volume
19
Issue
7
Pages
2121-2121
ISSN
1422-0067 (ISSN-L)
DOI
10.20944/preprints201805.0395.v1
PMC
PMC6073136
OpenAlex
W2806793725
Cited by
27
References
0
Citations by year
2026: 3 · 2025: 3 · 2024: 2 · 2023: 8 · 2022: 7 · 2021: 3 · 2020: 1
FWCI
0.10
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • Preprints.org (acceptedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Japan Society for the Promotion of Science (16K08264)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
Keywords
Rhotekin, Rho GTPases, pleckstrin homology domain, PDZ-binding motif, protein-protein interaction, binding partners, neurons, cancer cells, small GTPases
MeSH terms
Animals, Humans, Protein Binding, GTP-Binding Proteins, rho GTP-Binding Proteins, Intracellular Signaling Peptides and Proteins, Apoptosis Regulatory Proteins

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