SARS-CoV-2 Infection in the Central Nervous System of a 1-Year-Old Infant Submitted to Complete Autopsy
Open accessAbstract
Coronavirus disease 2019 (COVID-19) was initially characterized as a respiratory illness. Neurological manifestations were reported mostly in severely affected patients. Routes for brain infection and the presence of virus particles in situ have not been well described, raising controversy about how the virus causes neurological symptoms. Here, we report the autopsy findings of a 1-year old infant with COVID-19. In addition to pneumonitis, meningitis and multiple organ damage related to thrombosis, a previous encephalopathy may have contributed to additional cerebral damage. SARS-CoV-2 infected the choroid plexus, ventricles, and cerebral cortex. This is the first evidence of SARS-CoV-2 detection in an infant post-mortem brain.
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SARS-CoV-2 seems to invade infants' brains, since immunohistochemical analysis of the postmortem brain of a 1-year-old infant showed positive staining in the choroid plexus, ventricles and cerebral cortex.
“SARS-CoV-2 also seems to invade infants’ brains, since immunohistochemical analysis of the postmortem brain of a 1-year-old infant showed positive staining in the choroid plexus, ventricles and cerebral cortex [27].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [27]
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References 47 · Cited by 51
Research works printed but not linked: 1
- [32]Lun MP Monuki ES Lehtinen MK. Development and functions of the choroid plexus-cerebrospinal fluid system Nat Rev Neurosci 16 2015 445 457 26174708 PMC4629451
- Authors
- Gomes, I. C., Karmirian, K., Oliveira, J., Pedrosa, C., Rosman, F. C., Chimelli, L., & Rehen, S.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- D’Or Institute for Research and Education (BR)
- Corresponding author
- Rehen, Stevens
- Venue
- The Lancet Regional Health - Americas
- Publisher
- MDPI AG
- Published
- 2020-09-13
- Volume
- 2
- Pages
- 100046-100046
- ISSN
- 2667-193X (ISSN-L)
- PMC
- PMC8397543
- OpenAlex
- W3198225422
- Cited by
- 51
- References
- 47
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 7 · 2023: 12 · 2022: 12 · 2021: 8 · 2020: 1
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- The Lancet Regional Health - Americas (publishedVersion, cc-by)
- Preprints.org (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Instituto D'Or de Pesquisa e Ensino
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Topics
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- SARS-CoV-2, COVID-19 pandemic, pediatric COVID-19, central nervous system infection, choroid plexus, viral neurotropism, blood-CSF barrier, brain histopathology, neuronal loss, cortical atrophy, viral pneumonia, autopsy findings
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