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Creatine Supplementation in Children and Adolescents
Preprint — published as 10.3390/nu13020664 · Paper page
Abstract
Creatine is a popular ergogenic aid among athletic populations with consistent evidence indicating that creatine supplementation also continues to be commonly used among adolescent populations. In addition, the evidence base supporting the therapeutic benefits of creatine supplementation for a plethora of clinical applications in both adults and children continues to grow. Among pediatric populations, a strong rationale exists for creatine to afford therapeutic benefits pertaining to multiple neuromuscular and metabolic disorders, with preliminary evidence for other subsets of clinical populations as well. Despite the strong evidence supporting the efficacy and safety of creatine supplementation among adult populations, less is known as to whether similar physiological benefits extend to children and adolescent populations, and in particular those adolescent populations who are regularly participating in high-intensity exercise training. While limited in scope, studies involving creatine supplementation and exercise performance in adolescent athletes generally report improvements in a number of ergogenic outcomes with limited evidence of ergolytic properties and consistent reports indicating no adverse events associated with supplementation. The purpose of this article is to summarize the rationale, prevalence of use, performance benefits, clinical applications, and safety of creatine use in children and adolescents.
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“A review highlights that creatine supplementation, when administered within recommended dosages and under professional guidance, may offer a favorable safety profile for youth athletes engaged in serious or competitive training [88].”
From Optimizing Performance Nutrition for Adolescent Athletes: A Review of Dietary Needs, Risks, and Practical Strategies (2025) · cites this paper as [88]
In the citing paper
“Most available safety data are self-reported, and studies often lack comprehensive laboratory assessments [88,91].”
From Use of Nutritional Strategies, Bioactive Compounds, and Dietary Supplements in Young Athletes: From Evidence to Potential Risks—A Narrative Review (2025) · cites this paper as [91]
In the citing paper
“Although several studies and trials have been conducted in adult subjects, in the past two decades, the use of this supplement has also increased among adolescents [67], who mainly use creatine to improve their athletic performance, strength, and muscle mass [68].”
From Nutrition for Children and Adolescents Who Practice Sport: A Narrative Review (2024) · cites this paper as [67]
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Citations
Cited by
Kreider, R. B., Jäger, R., & Purpura, M. (2022) · Nutrients · doi:10.3390/nu14051035 · Cited by 103
Nutrition for Children and Adolescents Who Practice Sport: A Narrative Review
Capra, M. E., Stanyevic, B., Giudice, A., Monopoli, D., Decarolis, N. M., Esposito, S., & Biasucci, G. (2024) · Nutrients · doi:10.3390/nu16162803 · Cited by 66
Everett, S. (2025) · Nutrients · doi:10.3390/nu17172792 · Cited by 37
De Zan, D., Eletti, F., Fiore, G., Di Girolamo, E., Bozzini, G. G. M., Perico, V., Tosi, M., Norsa, L., Zuccotti, G., & Verduci, E. (2025) · Nutrients · doi:10.3390/nu17132194 · Cited by 11
Farfán-Díaz, Á., Fuentes-Hinojosa, C., Andrade-Oyarzun, M., Garcia-Carrillo, E., Molina-Márquez, I., Yáñez-Sepúlveda, R., Castillo-Paredes, A., Barrera-González, D., & Montalva-Valenzuela, F. (2026) · Adolescents · doi:10.3390/adolescents6040059 · Cited by 1
Metadata
- Authors
- Jagim, A. R., & Kerksick, C. M.
- Publisher
- MDPI AG
- Published
- 2021-01-18
- Cited by
- 17
- References
- 0
- Type
- Preprint
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
