Use of Natural Deep Eutectic Solvents (NADES) for the Selective Fractionation of Bioactive Low Molecular Weight Carbohydrates
Open accessPreprint — published as 10.3390/foods12234355
Abstract
Natural deep eutectic solvents (NADES) have been shown as selective and environmentally friendly solvents for the extraction of bioactive compounds. However, studies on the solubility of low molecular weight carbohydrates (LMWC) in NADES are scarce. In this work, new solubility data of LMWC in NADES are provided and a new approach based on the use of these solvents for the efficient fractionation of bioactive carbohydrates was explored for the first time. Several mono- and disaccharides and three NADES based on choline chloride (ChCl) and different donors [2-ethylene glycol (EtG), glycerol (Gly) and ethanedioic acid dihydrate (Eth)] were considered. While degradation of carbohydrates, mainly ketoses, was detected with ChCl:Eth due to its acidic nature, ChCl:EtG and ChCl:Gly were found to be useful alternatives for selectively separating bioactive ketoses and their corresponding aldoses (e.g. lactulose/lactose and tagatose/galactose) present in equimolar binary mixtures. In addition, the usefulness of ChCl:EtG for the selective enrichment of lactulose to be used as food ingredient or nutraceutical was proven (from a 25% in the reaction mixture to a 56% in the purified sample). NADES could be used for the selective fractionation of value-added carbohydrates from interfering sugars for several applications including food science, engineering or pharmaceuticals.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
DESs' tunable polarity and viscosity allow selective extraction of a wide variety of substances, ranging from metal ions and dyes to natural bioactive compounds.
“Their tunable polarity and viscosity also allow for selective extraction of a wide variety of substances, ranging from metal ions and dyes to natural bioactive compounds [24].”
From Eco-Friendly Deep Eutectic Solvent-Based Extraction Technologies: A Comprehensive Review of Principles, Applications, and Comparative Insights (2026) · cites this paper as [24]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
No citation lists for this paper
No citation lists for this paper yet — checked again daily.
References 39 · Cited by 16
Research works printed but not linked: 1
- Oh, D.K. Tagatose: Properties, Applications, and Biotechnological Processes. Appl. Microbiol. Biotechnol. 2007, 76, 1-8.
- Authors
- Jiménez Amezcua, I., Martínez, M. I. L., Ruiz-Matute, A. I., & Sanz, M. L.
- Venue
- Foods
- Publisher
- MDPI AG
- Published
- 2023-11-09
- Volume
- 12
- Issue
- 23
- Pages
- 4355-4355
- ISSN
- 2304-8158 (ISSN-L)
- PMC
- PMC10706766
- OpenAlex
- W4389274757
- Cited by
- 16
- References
- 39
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 2 · 2023: 1
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Foods (publishedVersion, cc-by)
- Preprints.org (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Comunidad de Madrid (MCIN /AEI /10.13039/ 501100011033, IND2020/BIO-17409)
- Ministerio de Ciencia e Innovación (PID2019-106405GB-I00, IND2020/BIO-17409)
- Consejería de Sanidad, Comunidad de Madrid (IND2020/BIO-17409, PID2019-106405GB-I00)
- Agencia Estatal de Investigación (AEI//10.13039/501100011033/, 501100011033, 10.13039/501100011033, MCIN/AEI/10.13039/501 100 011 033, 13039, .13039/501100011033, 10.13039, AEI/10, PID2019)
- Topics
- Physical Sciences › Chemical Engineering › Catalysis › Ionic liquids properties and applications
- Physical Sciences › Chemical Engineering › Filtration and Separation › Chemical and Physical Properties in Aqueous Solutions
- Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
- Keywords
- natural deep eutectic solvents, low molecular weight carbohydrates, choline chloride, glycerol, lactulose, lactose, tagatose, galactose, carbohydrate degradation, bioactive carbohydrates
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
