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Ten “Cheat Codes” for Measuring Oxidative Stress in Humans
Open accessPreprint — published as 10.3390/antiox13070877 · Paper page
Abstract
Formidable and often seemingly insurmountable conceptual, technical, and methodological challenges hamper the measurement of oxidative stress in humans. For instance, fraught and flawed methods, such as the thiobarbituric acid reactive substances assay kits for lipid peroxidation, rate-limit progress. To advance translational redox research, we present ten comprehensive “cheat codes” for measuring oxidative stress in humans. The cheat codes include analytical approaches to assess reactive oxygen species, antioxidants, biomarkers of oxidative damage and redox regulation. They provide essential conceptual, technical, and methodological information inclusive of curated “do” and “don’t” guidelines. Given the biochemical complexity of oxidative stress, we present a research question-grounded decision tree guide for selecting the most appropriate cheat code (s) to implement in a prospective human experiment. Worked examples demonstrate the benefits of the decision tree-based cheat code selection tool. The ten cheat codes define an invaluable resource for measuring oxidative stress in humans.
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Cites
How many human proteoforms are there?
Aebersold, R., Agar, J. N., Amster, I. J., Baker, M. S., Bertozzi, C. R., Boja, E. S., Costello, C. E., Cravatt, B. F., Fenselau, C., Garcia, B. A., et al. (2018) · Nature Chemical Biology · doi:10.1038/nchembio.2576 · Cited by 907
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Metadata
- Authors
- Cobley, J., Margaritelis, N., Chatzinikolaou, P., Nikolaidis, M., & Davison, G.
- Affiliations
- University of Ulster (GB)
- Aristotle University of Thessaloniki (GR)
- Corresponding author
- Cobley, James
- Venue
- Antioxidants
- Publisher
- MDPI AG
- Published
- 2024-05-12
- Volume
- 13
- Issue
- 7
- Pages
- 877-877
- ISSN
- 2076-3921 (ISSN-L)
- PMC
- PMC11273696
- OpenAlex
- W4400905504
- Cited by
- 17
- References
- 1
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 3
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Antioxidants (publishedVersion, cc-by)
- Preprints.org (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (publishedVersion, cc-by)
- Discovery Research Portal (University of Dundee) (submittedVersion, cc-by)
- Ulster University Research Portal (Ulster University) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- reactive oxygen species, oxidative damage, redox regulation, lipid peroxidation, TBARS
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