The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Androgen insensitivity syndrome: a review
Open accessAbstract
Androgenic insensitivity syndrome is the most common cause of disorders of sexual differentiation in 46,XY individuals. It results from alterations in the androgen receptor gene, leading to a frame of hormonal resistance, which may present clinically under 3 phenotypes: complete (CAIS), partial (PAIS) or mild (MAIS). The androgen receptor gene has 8 exons and 3 domains, and allelic variants in this gene occur in all domains and exons, regardless of phenotype, providing a poor genotype - phenotype correlation in this syndrome. Typically, laboratory diagnosis is made through elevated levels of LH and testosterone, with little or no virilization. Treatment depends on the phenotype and social sex of the individual. Open issues in the management of androgen insensitivity syndromes includes decisions on sex assignment, timing of gonadectomy, fertility, physcological outcomes and genetic counseling.
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Cites
Structure of the homodimeric androgen receptor ligand-binding domain
Nadal, M., Prekovic, S., Gallastegui, N., Helsen, C., Abella, M., Zielinska, K., Gay, M., Vilaseca, M., Taulès, M., Houtsmuller, A. B., et al. (2017) · Nature Communications · doi:10.1038/ncomms14388 · Cited by 193
Cited by
Sex determination, gonadal sex differentiation, and plasticity in vertebrate species
Nagahama, Y., Chakraborty, T., Paul-Prasanth, B., Ohta, K., & Nakamura, M. (2021) · Physiological Reviews · doi:10.1152/physrev.00044.2019 · Cited by 346
Nordenström, A., Ahmed, S. F., van den Akker, E., Blair, J., Bonomi, M., Brachet, C., Broersen, L. H. A., Claahsen-van der Grinten, H. L., Dessens, A. B., Gawlik, A., et al. (2022) · European Journal of Endocrinology · doi:10.1530/eje-22-0073 · Cited by 108
Is There Room for SERMs or SARMs as Alternative Therapies for Adult Male Hypogonadism?
Giagulli, V. A., Silvestrini, A., Bruno, C., Triggiani, V., Mordente, A., & Mancini, A. (2020) · International Journal of Endocrinology · doi:10.1155/2020/9649838 · Cited by 14
Metadata
- Authors
- Batista, R. L., Costa, E. M. F., Rodrigues, A. D. S., Gomes, N. L., Faria, J. A., Nishi, M. Y., Arnhold, I. J. P., Domenice, S., & Mendonca, B. B. D.
- Venue
- Archives of Endocrinology and Metabolism
- Published
- 2018-04
- Volume
- 62
- Issue
- 2
- Pages
- 227-235
- ISSN
- 2359-3997 (ISSN-L)
- 2359-4292
- OpenAlex
- W2806975196
- Cited by
- 186
- References
- 1
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- diamond
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- Batista, R. L., Costa, E. M. F., Rodrigues, A. D. S., Gomes, N. L., Faria, J. A., Nishi, M. Y., Arnhold, I. J. P., Domenice, S., & Mendonca, B. B. D. (2018). Androgen insensitivity syndrome: a review. Archives of Endocrinology and Metabolism. https://doi.org/10.20945/2359-3997000000031
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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