GLP-1 analogue liraglutide as adjunct treatment in diabetes type 2 after failed bariatric/metabolic surgery
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Obesity with its negative effect on health (1) has become a major challenge to physicians as well as surgeons throughout the world. Today more than 650 million people worldwide are obese (1). To the physician, the individuals’ positive energy balance with a greater energy intake than expenditure means an increased rate of diabetes type 2 and insulin resistance along with debilitating complications such as hypertension, stroke and cardiac disease, sleep respiratory disorders including sleep disturbance, blood lipid abnormalities and non-alcoholic fatty liver disease. To the surgeon, the problem mainly deals with the stigmatizing body composition, excessive accumulation of adipose tissue and immobility. Furthermore, there is a link to a number of cancers, such as endometrium, breast, ovary, prostate, liver, gallbladder, kidney, and colorectal cancer.
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Weight loss with liraglutide in clinical trials was of lesser magnitude and appeared to plateau earlier (at 20 or 40 weeks) than with semaglutide in the present trial (at 60-68 weeks).
“weight loss with liraglutide in clinical trials was of lesser magnitude and appeared to plateau earlier (at 20 weeks 31 or 40 weeks 30 ) than with semaglutide in the present trial (at 60-68 weeks).”
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The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review
Klok, M. D., Jakobsdottir, S., & Drent, M. L. (2007) · Obesity Reviews · doi:10.1111/j.1467-789x.2006.00270.x · Cited by 1,442 · see citing works
Gloy, V. L., Briel, M., Bhatt, D. L., Kashyap, S. R., Schauer, P. R., Mingrone, G., Bucher, H. C., & Nordmann, A. J. (2013) · BMJ · doi:10.1136/bmj.f5934 · Cited by 1,351 · see citing works
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Rubino, D., Abrahamsson, N., Davies, M., Hesse, D., Greenway, F. L., Jensen, C., Lingvay, I., Mosenzon, O., Rosenstock, J., Rubio, M. A., et al. (2021) · JAMA · doi:10.1001/jama.2021.3224 · Cited by 1,444 · see citing works
- Authors
- Hellström, P. M.
- Affiliations
- Uppsala University (SE)
- Corresponding author
- Hellström, Per M.
- ORCID
- Hellström, Per M.
- Venue
- Annals of Translational Medicine
- Publisher
- AME Publishing Company
- Published
- 2019-09
- Volume
- 7
- Issue
- S6
- Pages
- S240-S240
- ISSN
- 2305-5839 (ISSN-L)
- 2305-5847
- PMC
- PMC6789358
- OpenAlex
- W2971372343
- Cited by
- 6
- References
- 2
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 1 · 2021: 1
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Annals of Translational Medicine (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- liraglutide, GLP-1 receptor agonists, type 2 diabetes, obesity, metabolic surgery, adjunctive therapy, insulin resistance
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