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Cited by 182Periodontal Regeneration and TreatmentsKnee injuries and reconstruction techniquesBone fractures and treatments

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Enhanced Tibial Osteotomy Healing with Use of Bone Grafts Supplemented with Platelet Gel or Platelet Gel and Bone Marrow Stromal Cells

Dallari, D., Savarino, L., Stagni, C., Cenni, E., Cenacchi, A., Fornasari, P.M., Albisinni, U., Rimondi, E., Baldini, N., Giunti, A.·2007·The Journal of Bone & Joint Surgery
DOI 10.2106/jbjs.f.01026
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Abstract

BACKGROUND: There is great interest in the use of bone substitutes to improve bone repair. We compared the osteogenic potential of lyophilized bone chips combined with platelet gel, or with platelet gel and bone marrow stromal cells, with that of lyophilized bone chips alone in the healing of a high tibial osteotomy. METHODS: A prospective, randomized, controlled study was performed, and a standardized clinical model was applied. Thirty-three patients undergoing high tibial osteotomy to treat genu varum were enrolled and assigned to three groups. During the osteotomy, lyophilized bone chips with platelet gel were implanted into eleven patients (Group A), lyophilized bone chips with platelet gel and bone marrow stromal cells were implanted in twelve patients (Group B), and lyophilized bone chips without gel were placed in ten patients as controls (Group C). Six weeks after surgery, computed tomography-guided biopsies of the grafted areas were performed and the specimens were analyzed by histomorphometry. Clinical and radiographic evaluation was performed at six weeks, twelve weeks, six months, and one year after surgery. RESULTS: Histomorphometry at six weeks showed significantly increased osteoblasts and osteoid areas in both Group A (p = 0.006 and p = 0.03, respectively) and Group B (p = 0.009 and p = 0.001) in comparison with controls, as well as increased bone apposition on the chips (p = 0.007 and p = 0.001, respectively), which was greater in Group B than in Group A (p < 0.05). Group B showed significantly higher revascularization than the controls (p = 0.004). Radiographs revealed a significantly higher rate of osseointegration in Groups A and B than in the controls at six weeks (p < 0.005 and p < 0.0001, respectively). At the final evaluation at one year, the osseointegration was still better in Groups A and B than in Group C; however, all patients had complete clinical and functional evidence of healing. CONCLUSIONS: Adding a platelet gel or a platelet gel combined with bone marrow stromal cells to lyophilized bone chips increases the osteogenetic potential of the lyophilized bone chips and may be a useful tool in the treatment of patients with massive bone loss.

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Crossref · 10.2106/jbjs.f.01026

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Metadata

Authors
Dallari, D., Savarino, L., Stagni, C., Cenni, E., Cenacchi, A., Fornasari, P. M., Albisinni, U., Rimondi, E., Baldini, N., & Giunti, A.
Affiliations
Istituto Ortopedico Rizzoli (IT)
ORCID
Venue
The Journal of Bone & Joint Surgery
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2007-11
Volume
89
Issue
11
Pages
2413-2420
ISSN
0021-9355 (ISSN-L)
DOI
10.2106/jbjs.f.01026
OpenAlex
W2122711910
Cited by
182
References
39
Citations by year
2025: 4 · 2024: 5 · 2023: 2 · 2022: 5 · 2021: 8 · 2020: 6 · 2019: 7 · 2018: 5 · 2017: 9 · 2016: 12 · 2015: 15 · 2014: 17 · 2013: 15 · 2012: 17
FWCI
16.10
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Bone and Joint Surgery (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
Topics
  • Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
  • Health Sciences › Medicine › Surgery › Knee injuries and reconstruction techniques
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone fractures and treatments
Keywords
high tibial osteotomy, platelet gel, mesenchymal stem cells, bone grafting, genu varum, osseointegration, bone regeneration, bone formation, revascularization, bone substitutes, massive bone loss, histomorphometry, osteoblasts, osteoid, bone apposition, CT-guided biopsy
MeSH terms
Adult, Blood Platelets, Bone Marrow Cells, Female, Gels, Humans, Knee Joint, Male, Middle Aged, Osteotomy, Prospective Studies, Tibia, Wound Healing, Bone Transplantation, Stromal Cells, Osteoarthritis, Knee

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