Changes in thyroid hormone levels during zebrafish development
Abstract
The zebrafish (Danio rerio) has been used as a model for the study of endocrine disrupting chemicals. This study set out to determine the profiles of whole-body thyroxine (T4) and 3,5,3'-triiodothyronine (T3) levels during the development of zebrafish from embryo to adult. Enzyme-linked immunoassay was used to analyze whole-body T4 and T3 contents. The results showed that whole-body T4 and T3 levels remained stable during the pre-hatching period (0-3 d) and increased significantly during early development after hatching. The T3 level peaked at 0.28 ± 0.01 ng g(-1) body weight at 10 days post-fertilization (dpf), and T4 peaked at 0.58 ± 0.09 ng g(-1) body weight at 21 dpf. Both thyroid hormones subsequently declined during later development. This study establishes a baseline for thyroid hormones in zebrafish, which will be vital for the understanding of thyroid hormone functions and in future studies of thyroid toxicants in this species.
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Thyroid hormone levels are rising late in adult pattern formation.
“when TH levels are rising (Chang et al., 2012)”
From Thyroid hormone regulates distinct paths to maturation in pigment cell lineages (2019) · cites this paper as Chang et al., 2012
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Thyroid hormone regulates distinct paths to maturation in pigment cell lineages
Saunders, L. M., Mishra, A. K., Aman, A. J., Lewis, V. M., Toomey, M. B., Packer, J. S., Qiu, X., McFaline-Figueroa, J. L., Corbo, J. C., Trapnell, C., et al. (2019) · eLife · doi:10.7554/elife.45181 · Cited by 170 · see citing works
- Authors
- Chang, J., Wang, M., Gui, W., Zhao, Y., Yu, L., & Zhu, G.
- Affiliations
- Nanjing Agricultural University (CN)
- Zhejiang University (CN)
- Corresponding author
- Zhu, Guonian
- Venue
- Zoological Science
- Publisher
- Zoological Society of Japan
- Published
- 2012-03
- Volume
- 29
- Issue
- 3
- Pages
- 181-184
- ISSN
- 0289-0003 (ISSN-L)
- OpenAlex
- W2142908518
- Cited by
- 121
- References
- 0
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 9 · 2023: 10 · 2022: 9 · 2021: 8 · 2020: 8 · 2019: 16 · 2018: 16 · 2017: 10 · 2016: 4 · 2015: 8 · 2014: 6 · 2013: 3 · 2012: 1
- FWCI
- 4.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- ZOOLOGICAL SCIENCE (publishedVersion)
- PubMed (publishedVersion)
- BioOne Complete (BioOne) (submittedVersion)
- Funders
- National Science Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Keywords
- thyroid hormones, thyroxine, triiodothyronine, zebrafish development, endocrine disruptors
- MeSH terms
- Animals, Embryo, Nonmammalian, Thyroid Gland, Thyroxine, Time Factors, Triiodothyronine, Zebrafish
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