The Effect of L-citrulline Ingestion on ECG QT Interval and Autonomic Nervous System Activity
Open accessAbstract
The purpose of this study was to investigate the effect of L-citrulline ingestion on ECG QT interval. To accomplish this purpose, nine male subjects (age: 23.4±0.5 years, weight: 57.7±5.6 kg) participated, who had no history of cardiovascular or respiratory function disorders. Each subject performed two tests (L-citrulline and placebo ingestion) on a separate day. ECG was taken before, and 60 min and 90 min after L-citrulline ingestion. The heart-rate-corrected QT interval (QTc) decreased significantly 60 min (p=0.0004) and 90 min (p=0.011) after L-citrulline ingestion. However, there were no significant changes after placebo ingestion. In addition, the interaction between L-citrulline ingestion and placebo was significant (two-way ANOVA: interaction, p=0.010). Our major finding was that L-citrulline ingestion decreases the QT interval in healthy subjects. This result suggests that transient L-citrulline ingestion may shorten the time required to complete myocardial depolarization and repolarization.
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Earlier studies showed a decrease in QTc interval following acute consumption of citrulline.
“earlier studies showing a decrease in QTc interval (Kameda et al. 2011) following acute consumption of citrulline.”
From Oral nitrate and citrulline decrease blood pressure and increase vascular conductance in young adults: a potential therapy for heart failure (2016) · cites this paper as Kameda et al. 2011
Similar observations were noted for previous experiments exploiting the same dose of citrulline measured after only 60 min, but no direct measure of HR was made during these experiments.
“Similar observations were noted for previous experiments exploiting the same dose of citrulline measured after only 60 min, but no direct measure of HR was made during these experiments (Kameda et al. 2011).”
From Oral nitrate and citrulline decrease blood pressure and increase vascular conductance in young adults: a potential therapy for heart failure (2016) · cites this paper as Kameda et al. 2011
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References 29 · Cited by 14
- Authors
- Kameda, N., Okigawa, T., Kimura, T., Fujibayashi, M., Asada, T., Kinoshita, R., Baba, S., Morita, M., Morishita, K., & Moritani, T.
- Affiliations
- Sagami Women's Junior College (JP)
- Kyoto University (JP)
- Venue
- Journal of PHYSIOLOGICAL ANTHROPOLOGY
- Published
- 2011
- Volume
- 30
- Issue
- 2
- Pages
- 41-45
- ISSN
- 1880-6791 (ISSN-L)
- 1880-6805
- OpenAlex
- W2002954459
- Cited by
- 14
- References
- 29
- Citations by year
- 2023: 1 · 2021: 2 · 2017: 1 · 2016: 4 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of PHYSIOLOGICAL ANTHROPOLOGY (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- citrulline, QT interval, QTc interval, autonomic nervous system activity, myocardial repolarization, cardiac depolarization, dietary supplementation, healthy young men
- MeSH terms
- Analysis of Variance, Autonomic Nervous System, Citrulline, Electrocardiography, Humans, Male, Young Adult
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