Anti-herpes simplex virus type-1 activity of Eleusine indica methanol extract
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Aims: The present study is aimed at determining the antiviral activity of Eleusine indica whole plant methanol extract.Methodology and results: Whole dried plants were extracted with methanol and the solvent was evaporated using a rotary evaporator.The crude methanol extract was previously shown to have antiviral activity towards herpes simplex virus type 1 (HSV-1) with selective index (SI = CC50 / EC50) of 12.2.The extract was further studied for the possible mode of action including pretreatment, attachment, penetration or virucidal activity.The observations suggested that E. indica crude methanol extract protects cells from HSV-1 infection, inhibits virus from docking to the surface of the cells and penetrating into the cells, as well as modifying virus through the virucidal effect.Conclusion, significance and impact of study: Methanol extract of E. indica is safe with antiviral potential as a prophylactic agent, inhibits viral attachment, penetration and virucidal effect.
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Hexane extract of E. indica whole plant inhibited Vero cells greater than the aqueous extract (CC50 crude 2.07 mg/mL, hexane 5.62 mg/mL).
“Cytotoxic | Whole plant | Aqueous Hexane | Crude and hexane extract tested on Vero cells | CC 50 : - Crude: 2.07 mg/mL Hexane: 5.62 mg/mL | Hexane inhibited the cell greater than the aqueous extract”
From Eleusine Indica for Food and Medicine (2021) · cites this paper as Iberahim et al. (2016)
Methanol extract of E. indica whole plant has concentration-dependent activity against herpes simplex virus type 1 (HSV-1) (EC50 0.17 mg/mL, CC50 2.07 mg/mL).
“Antiviral | Whole plant | Methanol | Against herpes simplex virus type 1 (HSV-1) | EC 50 : 0.17 mg/mL CC 50 : 2.07 mg/mL | The activity of the extract against HSV-1 infection was concentration- dependent.”
From Eleusine Indica for Food and Medicine (2021) · cites this paper as Iberahim et al. (2016)
A CC50 value more than 0.02 mg/mL is considered as not cytotoxic to normal cells.
“The CC 50 value more than 0.02 mg/mL is considered as not cytotoxic to the normal cell”
From Eleusine Indica for Food and Medicine (2021) · cites this paper as Iberahim et al. (2016)
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Eleusine Indica for Food and Medicine
Zakri, Z. H. M., Suleiman, M., Ng, S. Y., Ngaini, Z., Maili, S., & Salim, F. (2021) · Journal of Agrobiotechnology · doi:10.37231/jab.2021.12.2.260 · Cited by 10 · see citing works
- Authors
- Iberahim, R., Ahamad Bahtiar, A., & Ibrahim, N.
- Affiliations
- National University of Malaysia (MY)
- ORCID
- Ibrahim, N.
- Venue
- Malaysian Journal of Microbiology
- Publisher
- Malaysian Journal of Microbiology
- Published
- 2016-07
- ISSN
- 1823-8262 (ISSN-L)
- 2231-7538
- OpenAlex
- W2609649377
- Cited by
- 6
- References
- 0
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- cc-by-nc
- Locations
- Malaysian Journal of Microbiology (publishedVersion, cc-by-nc)
- Funders
- Universiti Kebangsaan Malaysia (DPP-2015)
- Universiti Teknologi MARA
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Keywords
- Eleusine indica, herpes simplex virus type 1, antiviral activity, methanol extract, virucidal activity, viral attachment inhibition, selectivity index, plant-derived antiviral compounds, prophylactic agents
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