The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
The Hepatic Response to Thermal Injury: Is the Liver Important for Postburn Outcomes?
Open accessAbstract
Thermal injury produces a profound hypermetabolic and hypercatabolic stress response characterized by increased endogenous glucose production via gluconeogenesis and glycogenolysis, lipolysis, and proteolysis. The liver is the central body organ involved in these metabolic responses. It is suggested that the liver, with its metabolic, inflammatory, immune, and acute phase functions, plays a pivotal role in patient survival and recovery by modulating multiple pathways following thermal injury. Studies have evaluated the role and function of the liver during the postburn response and showed that liver integrity and function are essential for survival, and that hepatic acute phase proteins are strong predictors for postburn survival. This review discusses these studies and delineates the pivotal role of the liver in patients following severe thermal injury.
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Cites
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448
Lang, C. H., Dobrescu, C., & Bagby, G. J. (1992) · Endocrinology · doi:10.1210/endo.130.1.1727716 · Cited by 535
Effect of Severe Burn Injury on Substrate Cycling by Glucose and Fatty Acids
Wolfe, R. R., Herndon, D. N., Jahoor, F., Miyoshi, H., & Wolfe, M. (1987) · New England Journal of Medicine · doi:10.1056/nejm198708133170702 · Cited by 467
Cortisol increases gluconeogenesis in humans: its role in the metabolic syndrome
KHANI, S., & TAYEK, J. A. (2001) · Clinical Science · doi:10.1042/cs1010739 · Cited by 259
Aarsland, A., Chinkes, D., & Wolfe, R. R. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119005 · Cited by 212
Abnormal insulin sensitivity persists up to three years in pediatric patients post-burn
Gauglitz, G. G., Herndon, D. N., Kulp, G. A., Meyer, W. J., & Jeschke, M. G. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1947 · Cited by 186
Self-citationCharacterization of the inflammatory response during acute and post-acute phases after severe burn
Gauglitz, G. G., Song, J., Herndon, D. N., Finnerty, C. C., Boehning, D., Barral, J. M., & Jeschke, M. G. (2008) · Shock · doi:10.1097/shk.0b013e31816e3373 · Cited by 142
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Cited by
Burns: Pathophysiology of Systemic Complications and Current Management
Nielson, C. B., Duethman, N. C., Howard, J. M., Moncure, M., & Wood, J. G. (2017) · Journal of Burn Care & Research · doi:10.1097/bcr.0000000000000355 · Cited by 367
Metadata
- Authors
- Jeschke, M. G.
- Venue
- Molecular Medicine
- Published
- 2009-04-10
- Volume
- 15
- Issue
- 9-10
- Pages
- 337-351
- ISSN
- 1076-1551 (ISSN-L)
- 1528-3658
- OpenAlex
- W2203949277
- Cited by
- 172
- References
- 7
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- gold
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