PreprintCited by 84Acute Ischemic Stroke ManagementCardiovascular Health and Risk FactorsBlood Pressure and Hypertension Studies

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Prevalence of stroke and stroke related risk factors: a population based cross sectional survey in southwestern China

Open access

Preprint — published as 10.1186/s12883-019-1592-z · Paper page

Abstract

Background: Stroke and its risk factors epidemiological survey can help identify individuals at higher risk and therefore promote stroke prevention strategies. The aim of this study was to estimate the current prevalence of stroke and high risk stroke population, and evaluate stroke associated risk factors in southwestern China. Methods: This was a multi-center, cross sectional survey in southwestern China from May 2015 to September 2015. The 8 communities were selected at random, and 17413 residents aged ≥ 40 years volunteered to participate in this survey. Data were collected through face-to-face survey using a structured questionnaire. 521 participants with incomplete questionnaires on stroke history or risk factors records were excluded. Results: A total of 16892 people included in analysis. The overall prevalence of stroke was 3.1% (95% CI 2.6% - 3.9%), 17.1% of participants were the high risk stroke population. After full adjustments, hypertension, diabetes, dyslipidemia, overweight, lack of exercise and family history of stroke were significantly associated with overall stroke and ischemic stroke. The largest contributor was hypertension (population-attributable risk 23.6%), followed by dyslipidemia, physical inactivity, family history of stroke, diabetes, and overweight. However, only hypertension (OR = 3.66, 95% CI 1.82-8.23) was significantly associated with hemorrhagic stroke. Conclusions: The prevalence of stroke and high risk stroke population was high among adults aged ≥ 40 years in southwestern China. Hypertension, dyslipidemia and lack of exercise were stronger contributors for stroke, these findings suggest that individual-level and population-level interventions for these leading risk factors are necessary to prevent stroke.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.21203/rs.2.17357/v3

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 1 references

Research works printed but not linked: 37

  1. Guan T, Ma J, Li M, Xue T, Lan Z, Guo J, et al. Rapid transitions in the epidemiology of stroke and its risk factors in China from 2002 to 2013. Neurology. 2017;89:53–61. · DOI
  2. Jiang B, Wang WZ, Chen H, Hong Z, Yang QD, Wu SP, et al. Incidence and trends of stroke and its subtypes in China: results from three large cities. Stroke. 2006;37:63–8. · DOI
  3. Liu L, Wang D, Wong KS, Wang Y. Stroke and stroke care in China: huge burden, significant workload, and a national priority. Stroke. 2011;42:3651–4. · DOI
  4. Liu M, Wu B, Wang WZ, Lee LM, Zhang SH, Kong LZ. Stroke in China: epidemiology, prevention, and management strategies. Lancet Neurol. 2007;6:456–64. · DOI
  5. Wang Y, Cui L, Ji X, Dong Q, Zeng J, Wang Y, et al. The China National Stroke Registry for patients with acute cerebrovascular events: design, rationale, and baseline patient characteristics. Int J Stroke. 2011;6:355–61. · DOI
  6. Longde W, Ling Y, Yang H, Yi Z, Yongjun W, Xunming J, et al. Fixed-dose combination treatment after stroke for secondary prevention in China: a national community-based study. Stroke. 2015;46:1295–300. · DOI
  7. GBD 2016 Lifetime Risk of Stroke Collaborators. Feigin VL, Nguyen G, Cercy K, Johnson CO, Alam T, Parmar PG, et al. Global, Regional, and Country-Specific Lifetime Risks of Stroke, 1990 and 2016. N Engl J Med. 2018;379:2429–37. · DOI · Paper page
  8. Wu S, Wu B, Liu M, Chen Z, Wang W, Anderson CS, et al. Stroke in China: advances and challenges in epidemiology, prevention, and management. Lancet Neurol. 2019;18:394–405. · DOI
  9. Wang W, Jiang B, Sun H, Ru X, Sun D, Wang L, et al. Prevalence, incidence, and mortality of stroke in China: results from a nationwide population-based survey of 480687 adults. Circulation. 2017;135:759–71. · DOI
  10. Ru X, Wang W, Sun H, Sun D, Fu J, Ge S, et al. Geographical Difference, Rural-urban Transition and Trend in Stroke Prevalence in China: Findings from a National Epidemiological Survey of Stroke in China. Sci Rep. 2019;Nov 22;9(1):17330. doi:10.1038/s41598-019-53848-1. · DOI
  11. GBD 2016 Healthcare Access and Quality Collaborators. Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: a systematic analysis from the Global Burden of Disease Study 2016. Lancet. 2018;391:2236–71. · DOI · Paper page
  12. Krishnamurthi RV, Moran AE, Feigin VL, Barker-Collo S, Norrving B, Mensah GA,et al. Stroke prevalence, mortality and disability-adjusted life years in adults aged 20–64 years in 1990–2013: data from the global burden of disease 2013 study. Neuroepidemiology. 2015;45:190–202. · DOI
  13. Asplund K, Tuomilehto J, Stegmayr B, Wester PO, Tunstall-Pedoe H. Diagnostic criteria and quality control of the registration of stroke events in the MONICA project. Acta Med Scand Suppl. 1988;728:26–39. · DOI
  14. James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, et al. Evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA. 2014;311:507–20. · DOI · Paper page
  15. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2013;36:67–74. · DOI · Paper page
  16. Yi X, Han Z, Zhou Q, Lin J, Liu P. 20-Hydroxyeicosatetraenoic Acid as a Predictor of Neurological Deterioration in Acute Minor Ischemic Stroke. Stroke. 2016;47:3045–7. · DOI
  17. Rao W, Su Y, Yang G, Ma Y, Liu R, Zhang S, et al. Cross-sectional associations between body mass index and hyperlipidemia among adults in northeastern China. Int J Environ Res Public Health. 2016; 13(5). pii: E516. doi: 10.3390/ijerph13050516. · DOI
  18. Zhang FL, Guo ZN, Wu YH, Liu HY, Luo Y, Sun MS, et al. Prevalence of stroke and associated risk factors: a population based cross sectional studyfrom northeast China. BMJ Open. 2017;7(9):e015758. doi:10.1136/bmjopen-2016-015758. · DOI
  19. Lyden PD, Lu M, Levine SR, Brott TG, Broderick J. A modified National Institutes of Health Stroke Scale for use in stroke clinical trials: preliminaryreliability and validity. Stroke. 2001;32:1310–7. · DOI
  20. Stroke Screening and Prevention Project Committee NHaFPCoC. Technical specification of stroke screening and prevention in China. Chinese Journal of the Frontiers of Medical Science. 2013;9:44–50.
  21. Bruzzi P, Green SB, Byar DP, Brinton LA, Schairer C. Estimating the population attributable risk for multiple risk factors using case-control data. Am J Epidemiol. 1985;122:904–14. · DOI · Paper page
  22. Kooperberg C, Petitti DB. Using logistic regression to estimate the adjusted attributable risk of low birthweight in an unmatched case-control study. Epidemiology. 1991;2:363–6. · DOI
  23. Li SC, Schoenberg BS, Wang CC, Cheng XM, Bolis CL, Wang KJ. Cerebrovascular disease in the People's Republic of China: epidemiologic and clinical features. Neurology. 1985;35:1708–13. · DOI
  24. Cheng XM, Ziegler DK, Lai YH, Li SC, Jiang GX, Du XL, et al. Stroke in China, 1986 through 1990. Stroke. 1995;26:1990–4. · DOI
  25. Zhou M, Wang H, Zeng X, Yin P, Zhu J, Chen W, et al. Mortality, morbidity, and risk factors in China and its provinces, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2019 Jun 24. pii: S0140-6736(19)30427-1.
  26. O’Donnell MJ, Xavier D, Liu L, Zhang H, Chin SL, Rao-Melacini P, et al. Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. Lancet. 2010;376:112–23. · DOI · Paper page
  27. Mills KT, Bundy JD, Kelly TN, Reed JE, Kearney PM, Reynolds K, et al. Global disparities of hypertension prevalence and control clinical perspective. Circulation. 2016;134:441–50.
  28. Pan L, Yang Z, Wu Y, Yin RX, Liao Y, Wang J, et al. The prevalence, awareness, treatment and control of dyslipidemia among adults in China. Atherosclerosis. 2016;248:2–9. · DOI
  29. Wang S, Xu L, Jonas JB, You QS, Wang YX, Yang H. Prevalence and associated factors of dyslipidemia in the adult Chinese population. PLoS One. 2011;6:e17326. · DOI
  30. Kesteloot H, Huang DX, Yang XS, Claes J, Rosseneu M, Geboers J, et al. Serum lipids in the People’s Republic of China: comparison of western and eastern populations. Arteriosclerosis. 1985;5:427–33. · DOI
  31. Ng SW, Howard AG, Wang HJ, Su C, Zhang B. The physical activity transition among adults in China: 1991–2011. Obes Rev. 2014;15:27–36. · DOI
  32. Popkin BM. Synthesis and implications: China’s nutrition transition in the context of changes across other low- and middle-income countries. Obes Rev. 2014;15:60–7. · DOI
  33. Ng M, Freeman MK, Fleming TD, Robinson M, Dwyer-Lindgren L, Thomson B, et al. Smoking prevalence and cigarette consumption in 187 countries, 1980–2012. JAMA. 2014;311:183–92. · DOI · Paper page
  34. Feigin VL, Roth GA, Naghavi M, Parmar P, Krishnamurthi R, Chugh S, et al. Global burden of diseases, injuries and risk factors study 2013 and stroke experts writing group; global burden of stroke and risk factors in 188 countries, during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet Neurol. 2016;15:913–24.
  35. Liu M, Wu B, Wang WZ, Lee LM, Zhang SH, Kong LZ. Stroke in China: epidemiology, prevention, and management strategies. Lancet Neurol. 2007;6:456–64. · DOI
  36. Sposato LA, Cipriano LE, Saposnik G, Ruíz Vargas E, Riccio PM. Hachinski V. Diagnosis of atrial fibrillation after stroke and transient ischaemic attack: a systematic review and meta-analysis. Lancet Neurol. 2015;14:377–87. · DOI · Paper page
  37. Koga M, Yoshimura S, Hasegawa Y, Shibuya S, Ito Y, Matsuoka H, et al. SAMURAI Study Investigators. Higher Risk of Ischemic Events in Secondary Prevention for Patients With Persistent Than Those With Paroxysmal Atrial Fibrillation. Stroke. 2016;47:2582–8. · DOI

Metadata

Authors
Yi, X., Luo, H., Zhou, J., Yu, M., Chen, X., Tan, L., Wei, W., & Li, J.
Affiliations
  • people's hospital of deyang city
  • Southwest Medical University (CN)
  • people hospital fo deyang city
  • Suining Central Hospital
  • people hospital of deyang city
  • Peoples Hospital of Deyang City
Corresponding author
Yi, Xingyang
Venue
BMC Neurology
Published
2019-12-20
Volume
20
Issue
1
Pages
5-5
ISSN
1471-2377 (ISSN-L)
OpenAlex
W2998895956
Cited by
84
References
1
Citations by year
2026: 2 · 2025: 11 · 2024: 14 · 2023: 22 · 2022: 19 · 2021: 11 · 2020: 5
FWCI
10.21
Type
journal article
Language
en
Open access
Locations
  • BMC Neurology (publishedVersion, cc-by)
  • Research Square (acceptedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Health Department of Sichuan Province
Topics
  • Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
stroke prevalence, stroke risk factors, hypertension, dyslipidemia, physical inactivity, diabetes mellitus, overweight, family history of stroke, ischemic stroke, hemorrhagic stroke, population attributable risk, stroke prevention, Southwest China
MeSH terms
Adult, Aged, Aged, 80 and over, China, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Surveys and Questionnaires, Risk Factors, Prevalence, Stroke

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review