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Structural Basis for the self-recognition of sDSCAM in Chelicerata
Open accessPreprint — published as 10.1038/s41467-023-38205-1
Abstract
To create a functional neural circuit, neurons develop a molecular identity to discriminate self from non-self. The invertebrate Dscams and vertebrate Pcdhs are implicated in determining synaptic specificity. Recently identified in Chelicerata, a shortened Dscam (sDscam) has been shown to resemble the isoform-generating characters of both Dscam and Pcdh and represent an evolutionary transition. Here we presented the molecular details of sDscam self-recognition via both trans and cis interactions using X-ray crystallographic data, functional assays and mathematical analysis. Based on our results, we proposed a molecular zipper model for the assemblies of sDscam to mediate cell-cell recognition. In this model, sDscam utilized FNIII domain to form side-by-side interactions with neighboring molecules in the same cell while established hand-in-hand interactions via Ig1 domain with molecules from another cell around. Together, our study provided a framework for understanding the assembly, recognition, and evolution of sDscam.
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Cites
Highly accurate protein structure prediction with AlphaFold
Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., Žídek, A., Potapenko, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03819-2 · Cited by 43,764
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Metadata
- Authors
- Cheng, J., Yu, Y., Wang, X., Liu, T., Hu, D., Jin, Y., Lai, Y., Fu, T.-M., & Chen, Q.
- Affiliations
- Sichuan University (CN)
- Zhejiang University (CN)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- Corresponding author
- Chen, Qiang
- Venue
- Nature Communications
- Published
- 2022-08-29
- Volume
- 14
- Issue
- 1
- Pages
- 2522-2522
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC10154414
- OpenAlex
- W4367693178
- Cited by
- 5
- References
- 1
- Citations by year
- 2024: 4 · 2023: 1
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Research Square (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (31630089, 31741027, 32270761)
- Zhejiang University (SN-ZJU-SIAS009)
- Sichuan University
- West China Hospital, Sichuan University
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Dscam, self-recognition, Chelicerata, synaptic specificity, cell-cell recognition, FNIII domain, isoform diversity, invertebrate neurons
- MeSH terms
- Animals, Arthropods, Neurons, Cell Adhesion Molecules, Protein Isoforms
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