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Pm57 from Aegilops searsii encodes a novel tandem kinase protein conferring powdery mildew resistance in bread wheat
Open accessPreprint — published as 10.1038/s41467-024-49257-2
Abstract
Powdery mildew is a devastating disease that affects wheat yield and quality. Despite wheat wild relatives being a valuable source of resistance genes, their incorporation into wheat improvement is constrained by their adverse effects on agronomic traits, difficulty in isolating genes and poor understanding of the resistance mechanisms. Here, we report cloning of Pm57, the first gene isolated from Aegilops searsii. It encodes an unusual wheat tandem kinase (WTK) protein with putative kinase-pseudokinase domains followed by a von Willebrand factor A (vWA) domain, designated WTK7-vWA. The resistance function of Pm57 was validated by independent mutants, gene silencing, and transgenic assays. Stable Pm57 transgenic wheat lines showed high levels and all-stage resistance against diverse isolates of Bgt fungus with no adverse effects on agronomic traits. Our findings highlight the emerging role of kinase fusion proteins in plant disease resistance and provide a powerful gene for wheat breeding.
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Highly accurate protein structure prediction with AlphaFold
Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., Žídek, A., Potapenko, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03819-2 · Cited by 43,764
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Metadata
- Authors
- Liu, W., Zhao, Y., Dong, Z., Miao, J., Liu, Q., Ma, C., Tian, X., He, J., Bi, H., Yao, W., Li, T., Gill, H., Zhang, Z., Cao, A., Liu, B., Li, H., & Sehgal, S.
- Affiliations
- Henan Agricultural University (CN)
- Nanjing Agricultural University (CN)
- South Dakota State University (US)
- Northeast Normal University (CN)
- Corresponding author
- Liu, Wenxuan
- Li, Huanhuan
- Sehgal, Sunish
- ORCID
- Venue
- Nature Communications
- Published
- 2023-04-28
- Volume
- 15
- Issue
- 1
- Pages
- 4796-4796
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC11153570
- OpenAlex
- W4399368031
- Cited by
- 66
- References
- 1
- Citations by year
- 2026: 22 · 2025: 31 · 2024: 9 · 2023: 4
- FWCI
- 15.13
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Research Square (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- U.S. Department of Agriculture (2022-68013-36439)
- Yantai University
- National Natural Science Foundation of China (31971887, 31801363, 32272070, 32372089)
- China Agricultural University
- Chinese Academy of Sciences
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Powdery Mildew Fungal Diseases
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Wheat and Barley Genetics and Pathology
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant-Microbe Interactions and Immunity
- Keywords
- Aegilops searsii, wheat powdery mildew resistance, von Willebrand factor A domain, wild wheat relative, disease resistance genes, transgenic wheat, introgression lines, gene silencing, wheat breeding
- MeSH terms
- Plant Breeding, Aegilops, Ascomycota, Cloning, Molecular, Plant Diseases, Plant Proteins, Protein Kinases, Triticum, Gene Expression Regulation, Plant, Plants, Genetically Modified, Disease Resistance
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