Effect of astaxanthin on cutaneous wound healing
Open accessAbstract
Wound healing consists of a complex series of convoluted processes which involve renewal of the skin after injury. ROS are involved in all phases of wound healing. A balance between oxidative and antioxidative forces is necessary for a favorable healing outcome. Astaxanthin, a member of the xanthophyll group, is considered a powerful antioxidant. In this study, we investigated the effect of topical astaxanthin on cutaneous wound healing. Full-thickness dermal wounds were created in 36 healthy female mice, which were divided into a control group and a group receiving 78.9 µM topical astaxanthin treatment twice daily for 15 days. Astaxanthin-treated wounds showed noticeable contraction by day 3 of treatment and complete wound closure by day 9, whereas the wounds of control mice revealed only partial epithelialization and still carried scabs. Wound healing biological markers including Col1A1 and bFGF were significantly increased in the astaxanthin-treated group since day 1. Interestingly, the oxidative stress marker iNOS showed a significantly lower expression in the study. The results indicate that astaxanthin is an effective compound for accelerating wound healing.
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Carotenoids support healing processes.
“Furthermore, carotenoids support healing processes and protect the skin against the oxidative stress resulting from excessive ROS activity, thereby reducing the risk of skin cancer [220,226,232,236,237].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [236]
Carotenoids protect the skin against the oxidative stress resulting from excessive ROS activity.
“Furthermore, carotenoids support healing processes and protect the skin against the oxidative stress resulting from excessive ROS activity, thereby reducing the risk of skin cancer [220,226,232,236,237].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [236]
Carotenoids reduce the risk of skin cancer.
“Furthermore, carotenoids support healing processes and protect the skin against the oxidative stress resulting from excessive ROS activity, thereby reducing the risk of skin cancer [220,226,232,236,237].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [236]
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References 31 · Cited by 105
- Authors
- Meephansan, J., Rungjang, A., Yingmema, W., Deenonpoe, R., & Ponnikorn, S.
- Affiliations
- Thammasat University (TH)
- Corresponding author
- Meephansan, Jitlada
- Venue
- Clinical Cosmetic and Investigational Dermatology
- Publisher
- Informa UK Limited
- Published
- 2017-07
- Volume
- Volume 10
- Pages
- 259-265
- ISSN
- 1178-7015 (ISSN-L)
- PMC
- PMC5516620
- OpenAlex
- W2735218346
- Cited by
- 105
- References
- 31
- Citations by year
- 2026: 21 · 2025: 16 · 2024: 8 · 2023: 9 · 2022: 11 · 2021: 18 · 2020: 8 · 2019: 9 · 2018: 2 · 2017: 3
- FWCI
- 5.73
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinical Cosmetic and Investigational Dermatology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (acceptedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Funders
- Thammasat University (11/2558)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Keywords
- astaxanthin, skin wound healing, topical application, oxidative stress, reactive oxygen species, antioxidants, wound contraction, re-epithelialization, type I collagen, basic fibroblast growth factor, inducible nitric oxide synthase, xanthophylls
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