Current evidence and applications of photodynamic therapy in dermatology
Open accessAbstract
In photodynamic therapy (PDT) a photosensitizer - a molecule that is activated by light - is administered and exposed to a light source. This leads both to destruction of cells targeted by the particular type of photosensitizer, and immunomodulation. Given the ease with which photosensitizers and light can be delivered to the skin, it should come as no surprise that PDT is an increasingly utilized therapeutic in dermatology. PDT is used commonly to treat precancerous cells, sun-damaged skin, and acne. It has reportedly also been used to treat other conditions including inflammatory disorders and cutaneous infections. This review discusses the principles behind how PDT is used in dermatology, as well as evidence for current applications of PDT.
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ALA and MAL are absorbed into the skin becoming converted to protoporphyrin IX with a major absorption peak in the blue light spectrum (410 to 420 nm).
“Both are absorbed into the skin becoming converted to protoporphyrin IX with a major absorption peak in the blue light spectrum (410 to 420 nm).61,110”
From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [61]
PDT requires that a photosensitive drug is activated in the presence of light and oxygen to produce reactive oxygen intermediates that irreversibly damage cells.
“PDT requires that a photosensitive drug is activated in the presence of light and oxygen to produce reactive oxygen intermediates that irreversibly damage cells.61”
From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [61]
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References 206 · Cited by 248
Research works printed but not linked: 1
- [195]Dover JS Bhatia AC Stewart B Arndt KA Topical 5-aminolevulinic acid combined with intense pulsed light in the treatment of photoaging Arch Dermatol 2005 141 1247 1252 16230562
- Authors
- Lin, J., & Wan, M. T.
- Affiliations
- Brigham and Women's Hospital (US)
- Dana-Farber Cancer Institute (US)
- Corresponding author
- Lin, Jennifer
- ORCID
- Wan, Marilyn T.
- Venue
- Clinical, Cosmetic and Investigational Dermatology
- Publisher
- Informa UK Limited
- Published
- 2014-05
- Volume
- 7
- Pages
- 145
- ISSN
- 1178-7015 (ISSN-L)
- PMC
- PMC4038525
- OpenAlex
- W2102948081
- Cited by
- 248
- References
- 206
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 23 · 2023: 19 · 2022: 22 · 2021: 19 · 2020: 31 · 2019: 32 · 2018: 19 · 2017: 26 · 2016: 21 · 2015: 15 · 2014: 4
- FWCI
- 3.77
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinical Cosmetic and Investigational Dermatology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- photodynamic therapy, photosensitizers, immunomodulation, precancerous skin lesions, photodamaged skin, acne, inflammatory skin diseases, skin infections, dermatological applications
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